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Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

MedGen UID:
277379
•Concept ID:
C1334797
•
Neoplastic Process
Synonym: Monomorphic B-Cell PTLD

Definition

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm. [from NCI]

Professional guidelines

PubMed

Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article
Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment.
Chan TS, Hwang YY, Gill H, Au WY, Leung AY, Tse E, Chim CS, Loong F, Kwong YL
Clin Transplant 2012 Sep-Oct;26(5):679-83. Epub 2012 Feb 10 doi: 10.1111/j.1399-0012.2011.01593.x. PMID: 22324300

Recent clinical studies

Etiology

EBV and post-transplant lymphoproliferative disorder: a complex relationship.
El-Mallawany NK, Rouce RH
Hematology Am Soc Hematol Educ Program 2024 Nov 25;2024(1):728-735. doi: 10.1182/hematology.2024000583. PMID: 39644052
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article
Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial.
Trappe R, Oertel S, Leblond V, Mollee P, Sender M, Reinke P, Neuhaus R, Lehmkuhl H, Horst HA, Salles G, Morschhauser F, Jaccard A, Lamy T, Leithäuser M, Zimmermann H, Anagnostopoulos I, Raphael M, Riess H, Choquet S; German PTLD Study Group; European PTLD Network
Lancet Oncol 2012 Feb;13(2):196-206. Epub 2011 Dec 13 doi: 10.1016/S1470-2045(11)70300-X. PMID: 22173060

Diagnosis

Post-transplant lymphoproliferative disorder myeloradiculopathy.
Coradine TLC, Guida LOC, Fraiman P, Santos AJ, Pedroso JL, Barsottini OGP
Pract Neurol 2023 Oct;23(5):408-410. Epub 2023 May 5 doi: 10.1136/pn-2023-003696. PMID: 37147122
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article
Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial.
Trappe R, Oertel S, Leblond V, Mollee P, Sender M, Reinke P, Neuhaus R, Lehmkuhl H, Horst HA, Salles G, Morschhauser F, Jaccard A, Lamy T, Leithäuser M, Zimmermann H, Anagnostopoulos I, Raphael M, Riess H, Choquet S; German PTLD Study Group; European PTLD Network
Lancet Oncol 2012 Feb;13(2):196-206. Epub 2011 Dec 13 doi: 10.1016/S1470-2045(11)70300-X. PMID: 22173060

Therapy

EBV and post-transplant lymphoproliferative disorder: a complex relationship.
El-Mallawany NK, Rouce RH
Hematology Am Soc Hematol Educ Program 2024 Nov 25;2024(1):728-735. doi: 10.1182/hematology.2024000583. PMID: 39644052
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article
Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial.
Trappe R, Oertel S, Leblond V, Mollee P, Sender M, Reinke P, Neuhaus R, Lehmkuhl H, Horst HA, Salles G, Morschhauser F, Jaccard A, Lamy T, Leithäuser M, Zimmermann H, Anagnostopoulos I, Raphael M, Riess H, Choquet S; German PTLD Study Group; European PTLD Network
Lancet Oncol 2012 Feb;13(2):196-206. Epub 2011 Dec 13 doi: 10.1016/S1470-2045(11)70300-X. PMID: 22173060

Prognosis

Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial.
Trappe R, Oertel S, Leblond V, Mollee P, Sender M, Reinke P, Neuhaus R, Lehmkuhl H, Horst HA, Salles G, Morschhauser F, Jaccard A, Lamy T, Leithäuser M, Zimmermann H, Anagnostopoulos I, Raphael M, Riess H, Choquet S; German PTLD Study Group; European PTLD Network
Lancet Oncol 2012 Feb;13(2):196-206. Epub 2011 Dec 13 doi: 10.1016/S1470-2045(11)70300-X. PMID: 22173060
Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
Ohta H, Fukushima N, Ozono K
Int J Hematol 2009 Sep;90(2):127-136. Epub 2009 Aug 12 doi: 10.1007/s12185-009-0399-x. PMID: 19669857

Clinical prediction guides

Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disease in liver transplant recipients.
Rubio-Manzanares Dorado M, Álamo Martínez JM, Bernal Bellido C, Marín Gómez LM, Suárez Artacho G, Cepeda Franco C, Wang J, Gómez Bravo MÁ, Padillo FJ
Rev Esp Enferm Dig 2017 Jun;109(6):406-413. doi: 10.17235/reed.2017.4228/2016. PMID: 28508661
Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma.
Rinaldi A, Capello D, Scandurra M, Greiner TC, Chan WC, Bhagat G, Rossi D, Morra E, Paulli M, Rambaldi A, Rancoita PM, Inghirami G, Ponzoni M, Moreno SM, Piris MA, Mian M, Chigrinova E, Zucca E, Favera RD, Gaidano G, Kwee I, Bertoni F
Br J Haematol 2010 May;149(4):569-77. Epub 2010 Mar 3 doi: 10.1111/j.1365-2141.2010.08125.x. PMID: 20230398
Genetic and phenotypic analysis of B-cell post-transplant lymphoproliferative disorders provides insights into disease biology.
Vakiani E, Basso K, Klein U, Mansukhani MM, Narayan G, Smith PM, Murty VV, Dalla-Favera R, Pasqualucci L, Bhagat G
Hematol Oncol 2008 Dec;26(4):199-211. doi: 10.1002/hon.859. PMID: 18457340

Recent systematic reviews

Post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation: a case report, meta-analysis, and systematic review.
Su YY, Yu YF, Yan ZY, Zhao YJ, Lou JW, Xue F, Xu M, Feng Q, Ji XB, Dong XY, Wang W, Liu CF, Peng J, Liu XG
Diagn Pathol 2024 Sep 7;19(1):122. doi: 10.1186/s13000-024-01544-8. PMID: 39244586Free PMC Article
Impact of the posttransplant lymphoproliferative disorder subtype on survival.
Koff JL, Li JX, Zhang X, Switchenko JM, Flowers CR, Waller EK
Cancer 2018 Jun 1;124(11):2327-2336. Epub 2018 Mar 26 doi: 10.1002/cncr.31339. PMID: 29579330Free PMC Article

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