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Nonanaplastic kidney Wilms tumor

MedGen UID:
277434
•Concept ID:
C1335062
•
Neoplastic Process
Synonyms: Nonanaplastic Kidney Wilms Tumor; nonanaplastic kidney Wilms tumor; Nonanaplastic Renal Wilm's Tumor; nonanaplastic renal Wilm's tumor; nonanaplastic renal Wilm's tumour; Nonanaplastic Renal Wilms Tumor; nonanaplastic renal Wilms tumor; nonanaplastic renal Wilms tumour; Nonanaplastic Renal Wilms' Tumor; nonanaplastic renal Wilms' tumor; nonanaplastic renal Wilms' tumour
 
Monarch Initiative: MONDO:0003316

Definition

Wilms tumor of the kidney characterized by the absence of nuclear anaplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNonanaplastic kidney Wilms tumor

Professional guidelines

PubMed

Evidence-based surgical guidelines for treating children with Wilms tumor in low-resource settings.
Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Treatment and outcome of Wilms' tumour patients: an analysis of all cases registered in the UKW3 trial.
Pritchard-Jones K, Moroz V, Vujanić G, Powis M, Walker J, Messahel B, Hobson R, Levitt G, Kelsey A, Mitchell C
Ann Oncol 2012 Sep;23(9):2457-2463. Epub 2012 Mar 13 doi: 10.1093/annonc/mds025. PMID: 22415585

Recent clinical studies

Etiology

Evidence-based surgical guidelines for treating children with Wilms tumor in low-resource settings.
Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Characteristics and outcomes of preoperatively treated patients with anaplastic Wilms tumors registered in the UK SIOP-WT-2001 and IMPORT study cohorts (2002-2020).
Vujanić GM, Mifsud W, Chowdhury T, Al-Saadi R, Pritchard-Jones K; Renal Tumour Special Interest Group of the Children's Cancer and Leukaemia Group
Cancer 2022 Apr 15;128(8):1666-1675. Epub 2022 Feb 4 doi: 10.1002/cncr.34107. PMID: 35119702
Prognostic significance of histopathological response to preoperative chemotherapy in unilateral Wilms' tumor: An analysis of 899 patients treated on the SIOP WT 2001 protocol in the UK-CCLG and GPOH studies.
Vujanić GM, D'Hooghe E, Graf N, Vokuhl C, Al-Saadi R, Chowdhury T, Pritchard-Jones K, Furtwängler R
Int J Cancer 2021 Sep 15;149(6):1332-1340. Epub 2021 Jun 22 doi: 10.1002/ijc.33707. PMID: 34109628
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Focal versus diffuse anaplasia in Wilms tumor--new definitions with prognostic significance: a report from the National Wilms Tumor Study Group.
Faria P, Beckwith JB, Mishra K, Zuppan C, Weeks DA, Breslow N, Green DM
Am J Surg Pathol 1996 Aug;20(8):909-20. doi: 10.1097/00000478-199608000-00001. PMID: 8712292

Diagnosis

Evidence-based surgical guidelines for treating children with Wilms tumor in low-resource settings.
Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Characteristics and outcomes of preoperatively treated patients with anaplastic Wilms tumors registered in the UK SIOP-WT-2001 and IMPORT study cohorts (2002-2020).
Vujanić GM, Mifsud W, Chowdhury T, Al-Saadi R, Pritchard-Jones K; Renal Tumour Special Interest Group of the Children's Cancer and Leukaemia Group
Cancer 2022 Apr 15;128(8):1666-1675. Epub 2022 Feb 4 doi: 10.1002/cncr.34107. PMID: 35119702
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Focal versus diffuse anaplasia in Wilms tumor--new definitions with prognostic significance: a report from the National Wilms Tumor Study Group.
Faria P, Beckwith JB, Mishra K, Zuppan C, Weeks DA, Breslow N, Green DM
Am J Surg Pathol 1996 Aug;20(8):909-20. doi: 10.1097/00000478-199608000-00001. PMID: 8712292
Anaplastic Wilms' tumor: clinical and pathologic studies.
Bonadio JF, Storer B, Norkool P, Farewell VT, Beckwith JB, D'Angio GJ
J Clin Oncol 1985 Apr;3(4):513-20. doi: 10.1200/JCO.1985.3.4.513. PMID: 2984344

Therapy

The effect of preoperative chemotherapy on histological subtyping and staging of Wilms tumors: The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms tumor trial 3 (UKW3) experience.
Vujanić GM, D'Hooghe E, Popov SD, Sebire NJ, Kelsey A
Pediatr Blood Cancer 2019 Mar;66(3):e27549. Epub 2018 Nov 8 doi: 10.1002/pbc.27549. PMID: 30408319
A gene expression signature for relapse of primary wilms tumors.
Li W, Kessler P, Yeger H, Alami J, Reeve AE, Heathcott R, Skeen J, Williams BR
Cancer Res 2005 Apr 1;65(7):2592-601. doi: 10.1158/0008-5472.CAN-04-1532. PMID: 15805255
Complete necrosis induced by preoperative chemotherapy in Wilms tumor as an indicator of low risk: report of the international society of paediatric oncology (SIOP) nephroblastoma trial and study 9.
Boccon-Gibod L, Rey A, Sandstedt B, Delemarre J, Harms D, Vujanic G, De Kraker J, Weirich A, Tournade MF
Med Pediatr Oncol 2000 Mar;34(3):183-90. doi: 10.1002/(sici)1096-911x(200003)34:3<183::aid-mpo4>3.0.co;2-o. PMID: 10696124
Focal versus diffuse anaplasia in Wilms tumor--new definitions with prognostic significance: a report from the National Wilms Tumor Study Group.
Faria P, Beckwith JB, Mishra K, Zuppan C, Weeks DA, Breslow N, Green DM
Am J Surg Pathol 1996 Aug;20(8):909-20. doi: 10.1097/00000478-199608000-00001. PMID: 8712292
Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor.
Douglass EC, Look AT, Webber B, Parham D, Wilimas JA, Green AA, Roberson PK
J Clin Oncol 1986 Jun;4(6):975-81. doi: 10.1200/JCO.1986.4.6.975. PMID: 3012007

Prognosis

Characteristics and outcomes of preoperatively treated patients with anaplastic Wilms tumors registered in the UK SIOP-WT-2001 and IMPORT study cohorts (2002-2020).
Vujanić GM, Mifsud W, Chowdhury T, Al-Saadi R, Pritchard-Jones K; Renal Tumour Special Interest Group of the Children's Cancer and Leukaemia Group
Cancer 2022 Apr 15;128(8):1666-1675. Epub 2022 Feb 4 doi: 10.1002/cncr.34107. PMID: 35119702
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.
Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C
Pediatr Blood Cancer 2022 Feb;69(2):e29401. Epub 2021 Oct 24 doi: 10.1002/pbc.29401. PMID: 34693628Free PMC Article
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties.
Vujanić GM, Schiavo Lena M, Sebire NJ
Virchows Arch 2019 Feb;474(2):227-234. Epub 2018 Dec 4 doi: 10.1007/s00428-018-2500-4. PMID: 30515564
Focal versus diffuse anaplasia in Wilms tumor--new definitions with prognostic significance: a report from the National Wilms Tumor Study Group.
Faria P, Beckwith JB, Mishra K, Zuppan C, Weeks DA, Breslow N, Green DM
Am J Surg Pathol 1996 Aug;20(8):909-20. doi: 10.1097/00000478-199608000-00001. PMID: 8712292
Anaplastic Wilms' tumor: clinical and pathologic studies.
Bonadio JF, Storer B, Norkool P, Farewell VT, Beckwith JB, D'Angio GJ
J Clin Oncol 1985 Apr;3(4):513-20. doi: 10.1200/JCO.1985.3.4.513. PMID: 2984344

Clinical prediction guides

A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage.
Uno K, Rastegar B, Jansson C, Durand G, Valind A, Chattopadhyay S, Bertolotti A, Ciceri S, Spreafico F, Collini P, Perotti D, Mengelbier LH, Gisselsson D
Mod Pathol 2024 Jan;37(1):100382. Epub 2023 Nov 10 doi: 10.1016/j.modpat.2023.100382. PMID: 37951357
Immunohistochemical expression of P53 protein in nephroblastoma: a predictor of unfavorable prognosis.
Morgan ED, Yahaya JJ, Ngaiza AI, Othieno E, Livex OA
J Egypt Natl Canc Inst 2023 Jul 31;35(1):23. doi: 10.1186/s43046-023-00183-2. PMID: 37518096
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.
Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C
Pediatr Blood Cancer 2022 Feb;69(2):e29401. Epub 2021 Oct 24 doi: 10.1002/pbc.29401. PMID: 34693628Free PMC Article
Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report.
Perotti D, Vecchi GD, Lualdi E, Testi MA, Sozzi G, Collini P, Spreafico F, Terenziani M, Fossati-Bellani F, Radice P
J Pediatr Hematol Oncol 2005 Oct;27(10):521-5. doi: 10.1097/01.mph.0000184309.22583.66. PMID: 16217254
A gene expression signature for relapse of primary wilms tumors.
Li W, Kessler P, Yeger H, Alami J, Reeve AE, Heathcott R, Skeen J, Williams BR
Cancer Res 2005 Apr 1;65(7):2592-601. doi: 10.1158/0008-5472.CAN-04-1532. PMID: 15805255

Recent systematic reviews

Evidence-based surgical guidelines for treating children with Wilms tumor in low-resource settings.
Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184

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