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Lung occult adenocarcinoma

MedGen UID:
277443
•Concept ID:
C1335096
•
Neoplastic Process
Synonyms: lung occult adenocarcinoma; Occult Adenocarcinoma of Lung; occult adenocarcinoma of lung; Occult Adenocarcinoma of the Lung; occult adenocarcinoma of the lung; Occult Lung Adenocarcinoma; occult lung adenocarcinoma
 
Monarch Initiative: MONDO:0004127

Definition

A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult adenocarcinoma

Professional guidelines

PubMed

Treatment for patients with unknown primary carcinoma and unfavorable prognostic factors.
Greco FA, Pavlidis N
Semin Oncol 2009 Feb;36(1):65-74. doi: 10.1053/j.seminoncol.2008.10.005. PMID: 19179190
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Molecular differential diagnosis of renal carcinoma: from microscopes to microsatellites.
Steiner G, Sidransky D
Am J Pathol 1996 Dec;149(6):1791-5. PMID: 8952515Free PMC Article

Recent clinical studies

Etiology

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Correlation with Spectral CT Imaging Parameters and Occult Lymph Nodes Metastases in Sufferers with Isolated Lung Adenocarcinoma.
Liu Y, Nie Y
Contrast Media Mol Imaging 2022;2022:5472446. Epub 2022 Jun 25 doi: 10.1155/2022/5472446. PMID: 35833081Free PMC Article
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Two types of ectopic Cushing syndrome or a continuum? Review.
Araujo Castro M, Marazuela Azpiroz M
Pituitary 2018 Oct;21(5):535-544. doi: 10.1007/s11102-018-0894-2. PMID: 29766359
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Diagnosis

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Bone metastases of unknown origin: epidemiology and principles of management.
Piccioli A, Maccauro G, Spinelli MS, Biagini R, Rossi B
J Orthop Traumatol 2015 Jun;16(2):81-6. Epub 2015 Mar 1 doi: 10.1007/s10195-015-0344-0. PMID: 25726410Free PMC Article
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

Therapy

Malignancies in Deceased Organ Donors: The Spanish Experience.
Mahíllo B, Martín S, Molano E, Navarro A, Castro P, Pont T, Andrés A, Galán J, López M, Oliver E, Martínez A, Mosteiro F, Roque R, Pérez-Redondo M, Cid-Cumplido M, Ballesteros MA, Daga D, Quindós B, Sancho M, Royo-Villanova M, Bernabé E, Muñoz R, Chacón JI, Coll E, Domínguez-Gil B
Transplantation 2022 Sep 1;106(9):1814-1823. Epub 2022 Apr 1 doi: 10.1097/TP.0000000000004117. PMID: 35421045
Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer.
Haque W, Singh A, Park HS, Teh BS, Butler EB, Zeng M, Lin SH, Welsh JW, Chang JY, Verma V
Acta Oncol 2022 Apr;61(4):403-408. Epub 2021 Dec 16 doi: 10.1080/0284186X.2021.2012253. PMID: 34913815
Occult mediastinal lymph node metastasis in FDG-PET/CT node-negative lung adenocarcinoma patients: Risk factors and histopathological study.
Miao H, Shaolei L, Nan L, Yumei L, Shanyuan Z, Fangliang L, Yue Y
Thorac Cancer 2019 Jun;10(6):1453-1460. Epub 2019 May 24 doi: 10.1111/1759-7714.13093. PMID: 31127706Free PMC Article
Therapy of adenocarcinoma of unknown primary: are we making progress?
Greco FA
J Natl Compr Canc Netw 2008 Nov;6(10):1061-7. doi: 10.6004/jnccn.2008.0079. PMID: 19176201
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Prognosis

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Two types of ectopic Cushing syndrome or a continuum? Review.
Araujo Castro M, Marazuela Azpiroz M
Pituitary 2018 Oct;21(5):535-544. doi: 10.1007/s11102-018-0894-2. PMID: 29766359
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Bone metastases of unknown origin: epidemiology and principles of management.
Piccioli A, Maccauro G, Spinelli MS, Biagini R, Rossi B
J Orthop Traumatol 2015 Jun;16(2):81-6. Epub 2015 Mar 1 doi: 10.1007/s10195-015-0344-0. PMID: 25726410Free PMC Article
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Clinical prediction guides

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Predicting occult lymph node metastasis by nomogram in patients with lung adenocarcinoma ≤2 cm.
Wang Z, Wu Y, Wang L, Gong L, Han C, Liang N, Li S
Future Oncol 2021 Jun;17(16):2005-2013. Epub 2021 Mar 31 doi: 10.2217/fon-2020-0905. PMID: 33784826
Radiomics Approach to Prediction of Occult Mediastinal Lymph Node Metastasis of Lung Adenocarcinoma.
Zhong Y, Yuan M, Zhang T, Zhang YD, Li H, Yu TF
AJR Am J Roentgenol 2018 Jul;211(1):109-113. Epub 2018 Apr 18 doi: 10.2214/AJR.17.19074. PMID: 29667885
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Recent systematic reviews

Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Klimek M
Postgrad Med 2019 Jun;131(5):309-318. Epub 2019 Apr 5 doi: 10.1080/00325481.2019.1595982. PMID: 30900501
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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