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Oral Cavity and Lip Precancerous Condition

MedGen UID:
277448
•Concept ID:
C1335125
•
Disease or Syndrome
Synonyms: Oral Cavity and Lip Premalignant Condition; Oral Potentially Malignant Disorders

Definition

A premalignant pathologic process that affects the mucosa surface of the oral cavity or lip. It includes leukoplakia, erythroplakia, and smoker''s keratosis. [from NCI]

Professional guidelines

PubMed

Actinic cheilitis: a treatment review.
Shah AY, Doherty SD, Rosen T
Int J Dermatol 2010 Nov;49(11):1225-34. doi: 10.1111/j.1365-4632.2010.04580.x. PMID: 20964646
A treatment for oral precancerous lesions: why do we not yet have a treatment?
Lozada-Nur F
Med Oral Patol Oral Cir Bucal 2009 Apr 1;14(4):E159-62. PMID: 19333182
Oral cancer detection. The importance of routine screening for prolongation of survival.
Chiodo GT, Eigner T, Rosenstein DI
Postgrad Med 1986 Aug;80(2):231-6. doi: 10.1080/00325481.1986.11699497. PMID: 3526308

Recent clinical studies

Etiology

Oral lichen planus and related lesions. What should we accept based on the available evidence?
González-Moles MÁ, Ramos-García P
Oral Dis 2023 Oct;29(7):2624-2637. Epub 2022 Dec 8 doi: 10.1111/odi.14438. PMID: 36371653
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Oral field cancerization: current evidence and future perspectives.
Angadi PV, Savitha JK, Rao SS, Sivaranjini Y
Oral Maxillofac Surg 2012 Jun;16(2):171-80. Epub 2012 Feb 22 doi: 10.1007/s10006-012-0317-x. PMID: 22354325

Diagnosis

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Oral leukoplakia, leukoerythroplakia, erythroplakia and actinic cheilitis: Analysis of 953 patients focusing on oral epithelial dysplasia.
de Azevedo AB, Dos Santos TCRB, Lopes MA, Pires FR
J Oral Pathol Med 2021 Sep;50(8):829-840. Epub 2021 Apr 19 doi: 10.1111/jop.13183. PMID: 33817883
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Oral and neck examination for early detection of oral cancer--a practical guide.
MacCarthy D, Flint SR, Healy C, Stassen LF
J Ir Dent Assoc 2011 Aug-Sep;57(4):195-9. PMID: 21922994

Therapy

Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Oral field cancerization: current evidence and future perspectives.
Angadi PV, Savitha JK, Rao SS, Sivaranjini Y
Oral Maxillofac Surg 2012 Jun;16(2):171-80. Epub 2012 Feb 22 doi: 10.1007/s10006-012-0317-x. PMID: 22354325
Actinic cheilitis: a treatment review.
Shah AY, Doherty SD, Rosen T
Int J Dermatol 2010 Nov;49(11):1225-34. doi: 10.1111/j.1365-4632.2010.04580.x. PMID: 20964646
Diseases of the lips.
Rogers RS 3rd, Bekic M
Semin Cutan Med Surg 1997 Dec;16(4):328-36. doi: 10.1016/s1085-5629(97)80025-9. PMID: 9421227
Oral lesions in organ transplant patients.
Seymour RA, Thomason JM, Nolan A
J Oral Pathol Med 1997 Aug;26(7):297-304. doi: 10.1111/j.1600-0714.1997.tb00219.x. PMID: 9250928

Prognosis

Oral lichen planus and related lesions. What should we accept based on the available evidence?
González-Moles MÁ, Ramos-García P
Oral Dis 2023 Oct;29(7):2624-2637. Epub 2022 Dec 8 doi: 10.1111/odi.14438. PMID: 36371653
Potentially malignant oral lesions: clinicopathological correlations.
Maia HC, Pinto NA, Pereira Jdos S, de Medeiros AM, da Silveira ÉJ, Miguel MC
Einstein (Sao Paulo) 2016 Jan-Mar;14(1):35-40. doi: 10.1590/S1679-45082016AO3578. PMID: 27074232Free PMC Article
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Oral field cancerization: current evidence and future perspectives.
Angadi PV, Savitha JK, Rao SS, Sivaranjini Y
Oral Maxillofac Surg 2012 Jun;16(2):171-80. Epub 2012 Feb 22 doi: 10.1007/s10006-012-0317-x. PMID: 22354325
Oral and neck examination for early detection of oral cancer--a practical guide.
MacCarthy D, Flint SR, Healy C, Stassen LF
J Ir Dent Assoc 2011 Aug-Sep;57(4):195-9. PMID: 21922994

Clinical prediction guides

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Development and validation of nomogram for prediction of malignant transformation in oral leukoplakia: A large-scale cohort study.
Wang T, Wang L, Yang H, Lu H, Zhang J, Li N, Guo CB
J Oral Pathol Med 2019 Jul;48(6):491-498. Epub 2019 May 15 doi: 10.1111/jop.12862. PMID: 30980769
Potentially malignant oral lesions: clinicopathological correlations.
Maia HC, Pinto NA, Pereira Jdos S, de Medeiros AM, da Silveira ÉJ, Miguel MC
Einstein (Sao Paulo) 2016 Jan-Mar;14(1):35-40. doi: 10.1590/S1679-45082016AO3578. PMID: 27074232Free PMC Article
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Oral melanotic macule and primary oral malignant melanoma: epidemiology, location involved, and clinical implications.
Shen ZY, Liu W, Bao ZX, Zhou ZT, Wang LZ
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jul;112(1):e21-5. doi: 10.1016/j.tripleo.2011.02.040. PMID: 21669356

Recent systematic reviews

Reported physical examination methods for screening of oral cancer and oral potentially malignant disorders: a systematic review.
Louredo BVR, de Lima-Souza RA, Pérez-de-Oliveira ME, Warnakulasuriya S, Kerr AR, Kowalski LP, Hunter KD, Prado-Ribeiro AC, Vargas PA, Santos-Silva ARD
Oral Surg Oral Med Oral Pathol Oral Radiol 2024 Feb;137(2):136-152. Epub 2023 Oct 16 doi: 10.1016/j.oooo.2023.10.005. PMID: 37989648
Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta-analysis.
Aghaeipour F, Salehiniya H, Abbaszadeh H
J Med Virol 2021 Nov;93(11):6089-6099. Epub 2021 Jul 6 doi: 10.1002/jmv.27161. PMID: 34180541

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