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Pancreatic adenosquamous carcinoma

MedGen UID:
277489
Concept ID:
C1335299
Neoplastic Process
Synonyms: Adenosquamous Carcinoma of Pancreas; adenosquamous carcinoma of pancreas; Adenosquamous Carcinoma of the Pancreas; adenosquamous carcinoma of the pancreas; adenosquamous pancreas carcinoma; PAASC; pancreas adenosquamous carcinoma; Pancreatic Adenoacanthoma; pancreatic adenoacanthoma; pancreatic adenosquamous cancer; Pancreatic Adenosquamous Carcinoma; pancreatic adenosquamous carcinoma; Pancreatic Mixed Squamous and Adenocarcinoma; pancreatic mixed squamous and adenocarcinoma; Pancreatic Mucoepidermoid Carcinoma; pancreatic mucoepidermoid carcinoma
 
Monarch Initiative: MONDO:0005614

Definition

A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic adenosquamous carcinoma

Professional guidelines

PubMed

Kuwahara T, Hara K, Mizuno N, Haba S, Okuno N, Kuraishi Y, Fumihara D, Yanaidani T, Ishikawa S, Yasuda T, Yamada M, Onishi S, Yamada K, Tanaka T, Tajika M, Niwa Y, Yamaguchi R, Shimizu Y
Endoscopy 2023 Feb;55(2):140-149. Epub 2022 Jun 10 doi: 10.1055/a-1873-7920. PMID: 35688454

Recent clinical studies

Etiology

Li Q, Zhou Z, Chen Y, Yu J, Zhang H, Meng Y, Zhu M, Li N, Zhou J, Liu F, Fang X, Li J, Wang T, Lu J, Zhang T, Xu J, Shao C, Bian Y
Abdom Radiol (NY) 2023 Jun;48(6):2074-2084. Epub 2023 Mar 25 doi: 10.1007/s00261-023-03801-8. PMID: 36964775
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Kuwahara T, Hara K, Mizuno N, Haba S, Okuno N, Kuraishi Y, Fumihara D, Yanaidani T, Ishikawa S, Yasuda T, Yamada M, Onishi S, Yamada K, Tanaka T, Tajika M, Niwa Y, Yamaguchi R, Shimizu Y
Endoscopy 2023 Feb;55(2):140-149. Epub 2022 Jun 10 doi: 10.1055/a-1873-7920. PMID: 35688454
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
Schawkat K, Tsai LL, Jaramillo-Cardoso A, Paez SN, Moser JA, Decicco C, Singer T, Glickman J, Brook A, Manning MA, Mortele KJ
Clin Imaging 2021 May;73:134-138. Epub 2020 Dec 3 doi: 10.1016/j.clinimag.2020.11.041. PMID: 33387918

Diagnosis

Li Q, Zhou Z, Chen Y, Yu J, Zhang H, Meng Y, Zhu M, Li N, Zhou J, Liu F, Fang X, Li J, Wang T, Lu J, Zhang T, Xu J, Shao C, Bian Y
Abdom Radiol (NY) 2023 Jun;48(6):2074-2084. Epub 2023 Mar 25 doi: 10.1007/s00261-023-03801-8. PMID: 36964775
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
Schawkat K, Tsai LL, Jaramillo-Cardoso A, Paez SN, Moser JA, Decicco C, Singer T, Glickman J, Brook A, Manning MA, Mortele KJ
Clin Imaging 2021 May;73:134-138. Epub 2020 Dec 3 doi: 10.1016/j.clinimag.2020.11.041. PMID: 33387918

Therapy

Auvray Kuentz M, Hautefeuille V, de Mestier L, Coutzac C, Lecomte T, Nardon V, Artru P, Turpin A, Drouillard A, Malka D, Tran-Minh ML, Trouilloud I, Lièvre A, Williet N, Pernot S, Touchefeu Y, Taieb J, Hammel P, Zaanan A
Int J Cancer 2023 May 1;152(9):1894-1902. Epub 2023 Jan 3 doi: 10.1002/ijc.34414. PMID: 36562310
Ren S, Tang HJ, Zhao R, Duan SF, Chen R, Wang ZQ
Curr Med Sci 2022 Feb;42(1):217-225. Epub 2022 Jan 28 doi: 10.1007/s11596-022-2535-2. PMID: 35089491
Connell CM, Brais R, Whitaker H, Upponi S, Beh I, Risdall J, Corrie P, Janowitz T, Jodrell DI
BMC Cancer 2020 Jan 15;20(1):38. doi: 10.1186/s12885-020-6516-1. PMID: 31941506Free PMC Article
Aurilio G, Macarulla T, Ramos JF, Fazio N, Nolè F, Iglesias C
Tumori 2011 Mar-Apr;97(2):239-42. doi: 10.1177/030089161109700220. PMID: 21617724
Shibagaki K, Fujita K, Nakayama S, Takenaka M, Fukuba N, Matsui S, Ozaka M, Yoshinaga H, Masuzawa A, Watanabe A, Fujiwara H, Sugawara A, Fujita T, Mukai H, Kinoshita Y
Int J Clin Oncol 2008 Feb;13(1):74-7. Epub 2008 Feb 29 doi: 10.1007/s10147-007-0690-x. PMID: 18307024

Prognosis

Li Q, Zhou Z, Chen Y, Yu J, Zhang H, Meng Y, Zhu M, Li N, Zhou J, Liu F, Fang X, Li J, Wang T, Lu J, Zhang T, Xu J, Shao C, Bian Y
Abdom Radiol (NY) 2023 Jun;48(6):2074-2084. Epub 2023 Mar 25 doi: 10.1007/s00261-023-03801-8. PMID: 36964775
Huang Z, Wang J, Zhang R, He A, Luo S, Wu R, Xiong J, Li M, Jin T, Li E, Wu L, Liao W
Cancer Med 2023 Apr;12(8):9926-9936. Epub 2023 Feb 27 doi: 10.1002/cam4.5700. PMID: 36850060Free PMC Article
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
Zhao X, Li H, Lyu S, Zhai J, Ji Z, Zhang Z, Zhang X, Liu Z, Wang H, Xu J, Fan H, Kou J, Li L, Lang R, He Q
Int J Biol Sci 2021;17(10):2590-2605. Epub 2021 Jun 22 doi: 10.7150/ijbs.58886. PMID: 34326696Free PMC Article

Clinical prediction guides

Huang Z, Wang J, Zhang R, He A, Luo S, Wu R, Xiong J, Li M, Jin T, Li E, Wu L, Liao W
Cancer Med 2023 Apr;12(8):9926-9936. Epub 2023 Feb 27 doi: 10.1002/cam4.5700. PMID: 36850060Free PMC Article
Auvray Kuentz M, Hautefeuille V, de Mestier L, Coutzac C, Lecomte T, Nardon V, Artru P, Turpin A, Drouillard A, Malka D, Tran-Minh ML, Trouilloud I, Lièvre A, Williet N, Pernot S, Touchefeu Y, Taieb J, Hammel P, Zaanan A
Int J Cancer 2023 May 1;152(9):1894-1902. Epub 2023 Jan 3 doi: 10.1002/ijc.34414. PMID: 36562310
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
Zhao R, Jia Z, Chen X, Ren S, Cui W, Zhao DL, Wang S, Wang J, Li T, Zhu Y, Tang X, Wang Z
Abdom Radiol (NY) 2019 Aug;44(8):2822-2834. doi: 10.1007/s00261-019-02060-w. PMID: 31187197
Tanigawa M, Naito Y, Akiba J, Kawahara A, Okabe Y, Ishida Y, Ishikawa H, Hisaka T, Fujita F, Yasunaga M, Shigaki T, Sudo T, Mihara Y, Nakayama M, Kondo R, Kusano H, Shimamatsu K, Okuda K, Akagi Y, Yano H
Pathol Res Pract 2018 Dec;214(12):2069-2074. Epub 2018 Oct 19 doi: 10.1016/j.prp.2018.10.006. PMID: 30477643

Recent systematic reviews

Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580

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