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Pancreatic adenosquamous carcinoma

MedGen UID:
277489
•Concept ID:
C1335299
•
Neoplastic Process
Synonyms: Adenosquamous Carcinoma of Pancreas; adenosquamous carcinoma of pancreas; Adenosquamous Carcinoma of the Pancreas; adenosquamous carcinoma of the pancreas; adenosquamous pancreas carcinoma; PAASC; pancreas adenosquamous carcinoma; Pancreatic Adenoacanthoma; pancreatic adenoacanthoma; pancreatic adenosquamous cancer; Pancreatic Adenosquamous Carcinoma; pancreatic adenosquamous carcinoma; Pancreatic Mixed Squamous and Adenocarcinoma; pancreatic mixed squamous and adenocarcinoma; Pancreatic Mucoepidermoid Carcinoma; pancreatic mucoepidermoid carcinoma
 
Monarch Initiative: MONDO:0005614

Definition

A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic adenosquamous carcinoma

Professional guidelines

PubMed

Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses.
Kuwahara T, Hara K, Mizuno N, Haba S, Okuno N, Kuraishi Y, Fumihara D, Yanaidani T, Ishikawa S, Yasuda T, Yamada M, Onishi S, Yamada K, Tanaka T, Tajika M, Niwa Y, Yamaguchi R, Shimizu Y
Endoscopy 2023 Feb;55(2):140-149. Epub 2022 Jun 10 doi: 10.1055/a-1873-7920. PMID: 35688454

Recent clinical studies

Etiology

Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study.
Auvray Kuentz M, Hautefeuille V, de Mestier L, Coutzac C, Lecomte T, Nardon V, Artru P, Turpin A, Drouillard A, Malka D, Tran-Minh ML, Trouilloud I, Lièvre A, Williet N, Pernot S, Touchefeu Y, Taieb J, Hammel P, Zaanan A
Int J Cancer 2023 May 1;152(9):1894-1902. Epub 2023 Jan 3 doi: 10.1002/ijc.34414. PMID: 36562310
Pancreatic Adenosquamous Carcinoma: Experience Within an Integrated Health Care System.
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma.
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
(18)F-FDG PET/CT feature of pancreatic adenosquamous carcinoma with pathological correlation.
Su W, Zhao S, Chen Y, Zuo C, Cui B, Wang M, Ren F
Abdom Radiol (NY) 2020 Mar;45(3):743-749. doi: 10.1007/s00261-019-02393-6. PMID: 31907569
CT and MR imaging features of pancreatic adenosquamous carcinoma and their correlation with prognosis.
Zhao R, Jia Z, Chen X, Ren S, Cui W, Zhao DL, Wang S, Wang J, Li T, Zhu Y, Tang X, Wang Z
Abdom Radiol (NY) 2019 Aug;44(8):2822-2834. doi: 10.1007/s00261-019-02060-w. PMID: 31187197

Diagnosis

Pancreatic Adenosquamous Carcinoma: Experience Within an Integrated Health Care System.
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma.
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
Identification of germline and somatic mutations in pancreatic adenosquamous carcinoma using whole exome sequencing.
Ma H, Song B, Guo S, Li G, Jin G
Cancer Biomark 2020;27(3):389-397. doi: 10.3233/CBM-190236. PMID: 31958074
Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature.
Salari B, Sheinbein DM, Rosman IS, Dehner LP
J Cutan Pathol 2020 Mar;47(3):263-268. Epub 2019 Nov 12 doi: 10.1111/cup.13582. PMID: 31587324

Therapy

Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study.
Auvray Kuentz M, Hautefeuille V, de Mestier L, Coutzac C, Lecomte T, Nardon V, Artru P, Turpin A, Drouillard A, Malka D, Tran-Minh ML, Trouilloud I, Lièvre A, Williet N, Pernot S, Touchefeu Y, Taieb J, Hammel P, Zaanan A
Int J Cancer 2023 May 1;152(9):1894-1902. Epub 2023 Jan 3 doi: 10.1002/ijc.34414. PMID: 36562310
Application of Unenhanced Computed Tomography Texture Analysis to Differentiate Pancreatic Adenosquamous Carcinoma from Pancreatic Ductal Adenocarcinoma.
Ren S, Tang HJ, Zhao R, Duan SF, Chen R, Wang ZQ
Curr Med Sci 2022 Feb;42(1):217-225. Epub 2022 Jan 28 doi: 10.1007/s11596-022-2535-2. PMID: 35089491
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Connell CM, Brais R, Whitaker H, Upponi S, Beh I, Risdall J, Corrie P, Janowitz T, Jodrell DI
BMC Cancer 2020 Jan 15;20(1):38. doi: 10.1186/s12885-020-6516-1. PMID: 31941506Free PMC Article
Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma.
Aurilio G, Macarulla T, Ramos JF, Fazio N, Nolè F, Iglesias C
Tumori 2011 Mar-Apr;97(2):239-42. doi: 10.1177/030089161109700220. PMID: 21617724
Complete response of a pancreatic adenosquamous carcinoma to chemoradiotherapy.
Shibagaki K, Fujita K, Nakayama S, Takenaka M, Fukuba N, Matsui S, Ozaka M, Yoshinaga H, Masuzawa A, Watanabe A, Fujiwara H, Sugawara A, Fujita T, Mukai H, Kinoshita Y
Int J Clin Oncol 2008 Feb;13(1):74-7. Epub 2008 Feb 29 doi: 10.1007/s10147-007-0690-x. PMID: 18307024

Prognosis

Pancreatic adenosquamous carcinoma: A population level analysis of epidemiological trends and prognosis.
Huang Z, Wang J, Zhang R, He A, Luo S, Wu R, Xiong J, Li M, Jin T, Li E, Wu L, Liao W
Cancer Med 2023 Apr;12(8):9926-9936. Epub 2023 Feb 27 doi: 10.1002/cam4.5700. PMID: 36850060Free PMC Article
Pancreatic Adenosquamous Carcinoma: Experience Within an Integrated Health Care System.
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
Single-cell sequencing reveals heterogeneity between pancreatic adenosquamous carcinoma and pancreatic ductal adenocarcinoma with prognostic value.
Zhang D, Wu S, Pan S, Wang M, Wang Z, He Z, Zhang G, Cui F, Song Y, Li W, Shi X, Huang H, Xu H
Front Immunol 2022;13:972298. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.972298. PMID: 36052088Free PMC Article
Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma.
Zhao X, Li H, Lyu S, Zhai J, Ji Z, Zhang Z, Zhang X, Liu Z, Wang H, Xu J, Fan H, Kou J, Li L, Lang R, He Q
Int J Biol Sci 2021;17(10):2590-2605. Epub 2021 Jun 22 doi: 10.7150/ijbs.58886. PMID: 34326696Free PMC Article

Clinical prediction guides

Pancreatic adenosquamous carcinoma: A population level analysis of epidemiological trends and prognosis.
Huang Z, Wang J, Zhang R, He A, Luo S, Wu R, Xiong J, Li M, Jin T, Li E, Wu L, Liao W
Cancer Med 2023 Apr;12(8):9926-9936. Epub 2023 Feb 27 doi: 10.1002/cam4.5700. PMID: 36850060Free PMC Article
Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study.
Auvray Kuentz M, Hautefeuille V, de Mestier L, Coutzac C, Lecomte T, Nardon V, Artru P, Turpin A, Drouillard A, Malka D, Tran-Minh ML, Trouilloud I, Lièvre A, Williet N, Pernot S, Touchefeu Y, Taieb J, Hammel P, Zaanan A
Int J Cancer 2023 May 1;152(9):1894-1902. Epub 2023 Jan 3 doi: 10.1002/ijc.34414. PMID: 36562310
The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma.
Polaski JT, Udy DB, Escobar-Hoyos LF, Askan G, Leach SD, Ventura A, Kannan R, Bradley RK
Elife 2021 Jan 6;10 doi: 10.7554/eLife.62209. PMID: 33404013Free PMC Article
(18)F-FDG PET/CT feature of pancreatic adenosquamous carcinoma with pathological correlation.
Su W, Zhao S, Chen Y, Zuo C, Cui B, Wang M, Ren F
Abdom Radiol (NY) 2020 Mar;45(3):743-749. doi: 10.1007/s00261-019-02393-6. PMID: 31907569
CT and MR imaging features of pancreatic adenosquamous carcinoma and their correlation with prognosis.
Zhao R, Jia Z, Chen X, Ren S, Cui W, Zhao DL, Wang S, Wang J, Li T, Zhu Y, Tang X, Wang Z
Abdom Radiol (NY) 2019 Aug;44(8):2822-2834. doi: 10.1007/s00261-019-02060-w. PMID: 31187197

Recent systematic reviews

Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580

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