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Pancreatic ductal adenocarcinoma

MedGen UID:
277490
Concept ID:
C1335302
Neoplastic Process
Synonyms: Adenocarcinoma of pancreatic duct; Ductal adenocarcinoma of pancreas; Ductal Adenocarcinoma of Pancreas; ductal adenocarcinoma of pancreas; Ductal Adenocarcinoma of the Pancreas; ductal adenocarcinoma of the pancreas; malignant neoplasm of duct of Wirsung; Pancreas Ductal Adenocarcinoma; pancreas ductal adenocarcinoma; pancreatic duct adenocarcinoma; pancreatic duct cancer; Pancreatic Ductal Adenocarcinoma; pancreatic ductal adenocarcinoma; pancreatic ductal carcinoma; Pancreatic Infiltrating Duct Carcinoma, NOS; Pancreatic Infiltrating Duct Carcinoma, Not Otherwise Specified; Pancreatic Tubular Adenocarcinoma; pancreatic tubular adenocarcinoma; PDAC - pancreatic ductal adenocarcinoma
SNOMED CT: Pancreatic ductal adenocarcinoma (792907004); Ductal adenocarcinoma of pancreas (792907004); Adenocarcinoma of pancreatic duct (792907004); PDAC - pancreatic ductal adenocarcinoma (792907004)
 
Monarch Initiative: MONDO:0005184

Definition

An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor. [from NCI]

Professional guidelines

PubMed

Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium
Gut 2020 Jan;69(1):7-17. Epub 2019 Oct 31 doi: 10.1136/gutjnl-2019-319352. PMID: 31672839Free PMC Article

Recent clinical studies

Etiology

Taherian M, Wang H, Wang H
Cells 2022 Sep 29;11(19) doi: 10.3390/cells11193068. PMID: 36231030Free PMC Article
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Pereira SP, Oldfield L, Ney A, Hart PA, Keane MG, Pandol SJ, Li D, Greenhalf W, Jeon CY, Koay EJ, Almario CV, Halloran C, Lennon AM, Costello E
Lancet Gastroenterol Hepatol 2020 Jul;5(7):698-710. Epub 2020 Mar 2 doi: 10.1016/S2468-1253(19)30416-9. PMID: 32135127Free PMC Article
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513

Diagnosis

Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Chandana S, Babiker HM, Mahadevan D
Expert Opin Investig Drugs 2019 Feb;28(2):161-177. Epub 2018 Dec 16 doi: 10.1080/13543784.2019.1557145. PMID: 30539678
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA
Genes Dev 2006 May 15;20(10):1218-49. doi: 10.1101/gad.1415606. PMID: 16702400

Therapy

Conroy T, Castan F, Lopez A, Turpin A, Ben Abdelghani M, Wei AC, Mitry E, Biagi JJ, Evesque L, Artru P, Lecomte T, Assenat E, Bauguion L, Ychou M, Bouché O, Monard L, Lambert A, Hammel P; Canadian Cancer Trials Group and the Unicancer-GI–PRODIGE Group
JAMA Oncol 2022 Nov 1;8(11):1571-1578. doi: 10.1001/jamaoncol.2022.3829. PMID: 36048453Free PMC Article
Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH
Nat Med 2022 Jun;28(6):1167-1177. Epub 2022 Jun 3 doi: 10.1038/s41591-022-01829-9. PMID: 35662283Free PMC Article
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article

Prognosis

Hu JX, Zhao CF, Chen WB, Liu QC, Li QW, Lin YY, Gao F
World J Gastroenterol 2021 Jul 21;27(27):4298-4321. doi: 10.3748/wjg.v27.i27.4298. PMID: 34366606Free PMC Article
Okusaka T, Furuse J
J Gastroenterol 2020 Apr;55(4):369-382. Epub 2020 Jan 29 doi: 10.1007/s00535-020-01666-y. PMID: 31997007Free PMC Article
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J
Ann Surg 2018 May;267(5):936-945. doi: 10.1097/SLA.0000000000002234. PMID: 28338509
Luchini C, Capelli P, Scarpa A
Surg Pathol Clin 2016 Dec;9(4):547-560. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.003. PMID: 27926359

Clinical prediction guides

Sharma S, Tapper WJ, Collins A, Hamady ZZR
Gastroenterology 2022 May;162(6):1665-1674.e2. Epub 2022 Jan 21 doi: 10.1053/j.gastro.2022.01.016. PMID: 35065983
Tang R, Wu Z, Rong Z, Xu J, Wang W, Zhang B, Yu X, Shi S
Brief Bioinform 2022 Jan 17;23(1) doi: 10.1093/bib/bbab388. PMID: 34553745
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Golan T, O'Kane GM, Denroche RE, Raitses-Gurevich M, Grant RC, Holter S, Wang Y, Zhang A, Jang GH, Stossel C, Atias D, Halperin S, Berger R, Glick Y, Park JP, Cuggia A, Williamson L, Wong HL, Schaeffer DF, Renouf DJ, Borgida A, Dodd A, Wilson JM, Fischer SE, Notta F, Knox JJ, Zogopoulos G, Gallinger S
Gastroenterology 2021 May;160(6):2119-2132.e9. Epub 2021 Jan 30 doi: 10.1053/j.gastro.2021.01.220. PMID: 33524400
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article

Recent systematic reviews

Paolino G, Esposito I, Hong SM, Basturk O, Mattiolo P, Kaneko T, Veronese N, Scarpa A, Adsay V, Luchini C
Histopathology 2022 Sep;81(3):297-309. Epub 2022 May 27 doi: 10.1111/his.14698. PMID: 35583805Free PMC Article
Bunduc S, Gede N, Váncsa S, Lillik V, Kiss S, Juhász MF, Erőss B, Szakács Z, Gheorghe C, Mikó A, Hegyi P
Transl Res 2022 Jun;244:126-136. Epub 2022 Jan 20 doi: 10.1016/j.trsl.2022.01.001. PMID: 35066189
Casolino R, Paiella S, Azzolina D, Beer PA, Corbo V, Lorenzoni G, Gregori D, Golan T, Braconi C, Froeling FEM, Milella M, Scarpa A, Pea A, Malleo G, Salvia R, Bassi C, Chang DK, Biankin AV
J Clin Oncol 2021 Aug 10;39(23):2617-2631. Epub 2021 Jul 1 doi: 10.1200/JCO.20.03238. PMID: 34197182Free PMC Article
Luchini C, Brosens LAA, Wood LD, Chatterjee D, Shin JI, Sciammarella C, Fiadone G, Malleo G, Salvia R, Kryklyva V, Piredda ML, Cheng L, Lawlor RT, Adsay V, Scarpa A
Gut 2021 Jan;70(1):148-156. Epub 2020 Apr 29 doi: 10.1136/gutjnl-2020-320726. PMID: 32350089Free PMC Article
Chin V, Nagrial A, Sjoquist K, O'Connor CA, Chantrill L, Biankin AV, Scholten RJ, Yip D
Cochrane Database Syst Rev 2018 Mar 20;3(3):CD011044. doi: 10.1002/14651858.CD011044.pub2. PMID: 29557103Free PMC Article

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