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Pancreatic ductal adenocarcinoma

MedGen UID:
277490
•Concept ID:
C1335302
•
Neoplastic Process
Synonyms: Adenocarcinoma of pancreatic duct; Ductal adenocarcinoma of pancreas; Ductal Adenocarcinoma of Pancreas; ductal adenocarcinoma of pancreas; Ductal Adenocarcinoma of the Pancreas; ductal adenocarcinoma of the pancreas; malignant neoplasm of duct of Wirsung; Pancreas Ductal Adenocarcinoma; pancreas ductal adenocarcinoma; pancreatic duct adenocarcinoma; pancreatic duct cancer; Pancreatic Ductal Adenocarcinoma; pancreatic ductal adenocarcinoma; pancreatic ductal carcinoma; Pancreatic Infiltrating Duct Carcinoma, NOS; Pancreatic Infiltrating Duct Carcinoma, Not Otherwise Specified; Pancreatic Tubular Adenocarcinoma; pancreatic tubular adenocarcinoma; PDAC - pancreatic ductal adenocarcinoma
SNOMED CT: Pancreatic ductal adenocarcinoma (792907004); Ductal adenocarcinoma of pancreas (792907004); Adenocarcinoma of pancreatic duct (792907004); PDAC - pancreatic ductal adenocarcinoma (792907004)
 
Monarch Initiative: MONDO:0005184

Definition

An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor. [from NCI]

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article

Recent clinical studies

Etiology

Obesity associated pancreatic ductal adenocarcinoma: Therapeutic challenges.
Srilatha M, Malla R, Adem MP, Foote JB, Nagaraju GP
Semin Cancer Biol 2023 Dec;97:12-20. Epub 2023 Nov 4 doi: 10.1016/j.semcancer.2023.11.002. PMID: 37926347
Pancreatic Ductal Adenocarcinoma: Molecular Pathology and Predictive Biomarkers.
Taherian M, Wang H, Wang H
Cells 2022 Sep 29;11(19) doi: 10.3390/cells11193068. PMID: 36231030Free PMC Article
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Deep learning radiomics based on contrast-enhanced ultrasound images for assisted diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis.
Tong T, Gu J, Xu D, Song L, Zhao Q, Cheng F, Yuan Z, Tian S, Yang X, Tian J, Wang K, Jiang T
BMC Med 2022 Mar 2;20(1):74. doi: 10.1186/s12916-022-02258-8. PMID: 35232446Free PMC Article
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article

Diagnosis

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Syndecans and Pancreatic Ductal Adenocarcinoma.
Betriu N, Bertran-Mas J, Andreeva A, Semino CE
Biomolecules 2021 Feb 25;11(3) doi: 10.3390/biom11030349. PMID: 33669066Free PMC Article
Rare pancreatic tumors.
Steinman J, Zaheer A, Kluger MD, Remotti H, Hecht EM
Abdom Radiol (NY) 2018 Feb;43(2):285-300. doi: 10.1007/s00261-017-1342-x. PMID: 29022085
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article

Therapy

Therapeutic developments in pancreatic cancer.
Hu ZI, O'Reilly EM
Nat Rev Gastroenterol Hepatol 2024 Jan;21(1):7-24. Epub 2023 Oct 5 doi: 10.1038/s41575-023-00840-w. PMID: 37798442
NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial.
Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O'Reilly EM
Lancet 2023 Oct 7;402(10409):1272-1281. Epub 2023 Sep 11 doi: 10.1016/S0140-6736(23)01366-1. PMID: 37708904
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma.
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article

Prognosis

Pancreatic cancer: A review of epidemiology, trend, and risk factors.
Hu JX, Zhao CF, Chen WB, Liu QC, Li QW, Lin YY, Gao F
World J Gastroenterol 2021 Jul 21;27(27):4298-4321. doi: 10.3748/wjg.v27.i27.4298. PMID: 34366606Free PMC Article
Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer.
Rashid NU, Peng XL, Jin C, Moffitt RA, Volmar KE, Belt BA, Panni RZ, Nywening TM, Herrera SG, Moore KJ, Hennessey SG, Morrison AB, Kawalerski R, Nayyar A, Chang AE, Schmidt B, Kim HJ, Linehan DC, Yeh JJ
Clin Cancer Res 2020 Jan 1;26(1):82-92. Epub 2019 Nov 21 doi: 10.1158/1078-0432.CCR-19-1467. PMID: 31754050Free PMC Article
Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature.
Benzel J, Fendrich V
Digestion 2018;97(4):275-287. Epub 2018 Mar 27 doi: 10.1159/000485741. PMID: 29587290
Pancreatic Ductal Adenocarcinoma and Its Variants.
Luchini C, Capelli P, Scarpa A
Surg Pathol Clin 2016 Dec;9(4):547-560. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.003. PMID: 27926359
Borderline resectable pancreatic cancer.
Hackert T, Ulrich A, Büchler MW
Cancer Lett 2016 Jun 1;375(2):231-237. Epub 2016 Mar 9 doi: 10.1016/j.canlet.2016.02.039. PMID: 26970276

Clinical prediction guides

The correlation between gut and intra-tumor microbiota and PDAC: Etiology, diagnostics and therapeutics.
Qian J, Zhang X, Wei B, Tang Z, Zhang B
Biochim Biophys Acta Rev Cancer 2023 Sep;1878(5):188943. Epub 2023 Jun 22 doi: 10.1016/j.bbcan.2023.188943. PMID: 37355177
Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma.
Ma LX, Wang Y, Espin-Garcia O, Allen MJ, Jang GH, Zhang A, Dodd A, Ramotar S, Hutchinson S, Tehfe M, Ramjeesingh R, Biagi J, Wilson JM, Notta F, Fischer SE, Zogopoulos G, Gallinger S, Grant RC, Khokha R, Chan N, Grünwald BT, Knox JJ, O'Kane GM
Br J Cancer 2023 May;128(10):1916-1921. Epub 2023 Mar 16 doi: 10.1038/s41416-023-02214-0. PMID: 36927977Free PMC Article
Predicting Pancreatic Cancer in the UK Biobank Cohort Using Polygenic Risk Scores and Diabetes Mellitus.
Sharma S, Tapper WJ, Collins A, Hamady ZZR
Gastroenterology 2022 May;162(6):1665-1674.e2. Epub 2022 Jan 21 doi: 10.1053/j.gastro.2022.01.016. PMID: 35065983
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Early Detection of Pancreatic Cancer: Opportunities and Challenges.
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article

Recent systematic reviews

NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Risk factors for early-onset pancreatic ductal adenocarcinoma: A systematic literature review.
Chandana SR, Woods LM, Maxwell F, Gandolfo R, Bekaii-Saab T
Eur J Cancer 2024 Feb;198:113471. Epub 2023 Dec 12 doi: 10.1016/j.ejca.2023.113471. PMID: 38154392
Predictive ability of pancreatic cyst fluid biomarkers: A systematic review and meta-analysis.
Pflüger MJ, Jamouss KT, Afghani E, Lim SJ, Rodriguez Franco S, Mayo H, Spann M, Wang H, Singhi A, Lennon AM, Wood LD
Pancreatology 2023 Nov;23(7):868-877. Epub 2023 May 15 doi: 10.1016/j.pan.2023.05.005. PMID: 37230894
Chemotherapy in pancreatic ductal adenocarcinoma: When cytoreduction is the aim. A systematic review and meta-analysis.
Meneses-Medina MI, Gervaso L, Cella CA, Pellicori S, Gandini S, Sousa MJ, Fazio N
Cancer Treat Rev 2022 Mar;104:102338. Epub 2022 Jan 22 doi: 10.1016/j.ctrv.2022.102338. PMID: 35114498
A systematic review of economic evaluation in pancreatic ductal adenocarcinoma.
Gérard C, Fagnoni P, Vienot A, Borg C, Limat S, Daval F, Calais F, Vardanega J, Jary M, Nerich V
Eur J Cancer 2017 Nov;86:207-216. Epub 2017 Oct 9 doi: 10.1016/j.ejca.2017.08.035. PMID: 29024890

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