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Pancreatic Intraductal Papillary-Mucinous Neoplasm with Intermediate Grade Dysplasia

MedGen UID:
277491
•Concept ID:
C1335305
•
Neoplastic Process

Definition

A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit nuclear stratification, loss of polarity, and crowding. There is moderate nuclear hyperchromasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary-Mucinous Neoplasm with Intermediate Grade Dysplasia

Professional guidelines

PubMed

The 2012 International Consensus Guidelines of Intraductal Papillary Mucinous Neoplasms of the Pancreas (Fukuoka Criteria) Predict the Malignant Potential, Even in Actual Clinical Situations.
Okamura Y, Sano S, Sugiura T, Ito T, Yamamoto Y, Ashida R, Ishiwatari H, Matsubayashi H, Sasaki K, Uesaka K
Pancreas 2018 Mar;47(3):285-290. doi: 10.1097/MPA.0000000000001001. PMID: 29401172
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Pancreatic Cancer Screening for At-Risk Individuals (Pancreas Scan Study): Yield, Harms, and Outcomes From a Prospective Multicenter Study.
Shah I, Silva-Santisteban A, Germansky KA, Trindade A, Raphael KL, Kushnir V, Pawa R, Mishra G, Anastasiou J, Inamdar S, Tharian B, Bilal M, Sawhney MS
Am J Gastroenterol 2023 Sep 1;118(9):1664-1670. Epub 2023 May 4 doi: 10.14309/ajg.0000000000002314. PMID: 37141538
Management and outcomes of intraductal papillary mucinous neoplasms.
Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA
BJS Open 2019 Aug;3(4):490-499. Epub 2019 Mar 21 doi: 10.1002/bjs5.50156. PMID: 31388641Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Diagnosis

Pancreatic Cancer Screening for At-Risk Individuals (Pancreas Scan Study): Yield, Harms, and Outcomes From a Prospective Multicenter Study.
Shah I, Silva-Santisteban A, Germansky KA, Trindade A, Raphael KL, Kushnir V, Pawa R, Mishra G, Anastasiou J, Inamdar S, Tharian B, Bilal M, Sawhney MS
Am J Gastroenterol 2023 Sep 1;118(9):1664-1670. Epub 2023 May 4 doi: 10.14309/ajg.0000000000002314. PMID: 37141538
Telomere Attrition in Intraductal Papillary Mucinous Neoplasms of the Pancreas Associated With Carcinogenesis and Aging.
Miki A, Matsuda Y, Aida J, Watanabe J, Sanada Y, Sakuma Y, Lefor AK, Fukushima N, Sata N, Arai T, Takubo K, Ishiwata T
Pancreas 2022 Jul 1;51(6):678-683. doi: 10.1097/MPA.0000000000002081. PMID: 36206470
Assessment of Malignancy Potential in Intraductal Papillary Mucinous Neoplasms of the Pancreas on MDCT.
Chai L, Zhu N, Wang Q, Wang T, Chai W
Acad Radiol 2021 May;28(5):679-686. Epub 2020 Jun 24 doi: 10.1016/j.acra.2020.03.042. PMID: 32591278
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Therapy

EUS-guided confocal laser endomicroscopy: prediction of dysplasia in intraductal papillary mucinous neoplasms (with video).
Krishna SG, Hart PA, DeWitt JM, DiMaio CJ, Kongkam P, Napoleon B, Othman MO, Yew Tan DM, Strobel SG, Stanich PP, Patel A, Luthra AK, Chan MQ, Blaszczak AM, Lee D, El-Dika S, McCarthy ST, Walker JP, Arnold CA, Porter K, Conwell DL
Gastrointest Endosc 2020 Mar;91(3):551-563.e5. Epub 2019 Sep 19 doi: 10.1016/j.gie.2019.09.014. PMID: 31542380
Management and outcomes of intraductal papillary mucinous neoplasms.
Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA
BJS Open 2019 Aug;3(4):490-499. Epub 2019 Mar 21 doi: 10.1002/bjs5.50156. PMID: 31388641Free PMC Article
Preoperative risk prediction for intraductal papillary mucinous neoplasms by quantitative CT image analysis.
Attiyeh MA, Chakraborty J, Gazit L, Langdon-Embry L, Gonen M, Balachandran VP, D'Angelica MI, DeMatteo RP, Jarnagin WR, Kingham TP, Allen PJ, Do RK, Simpson AL
HPB (Oxford) 2019 Feb;21(2):212-218. Epub 2018 Aug 7 doi: 10.1016/j.hpb.2018.07.016. PMID: 30097414Free PMC Article
Technical Feasibility and Oncological Legitimacy of Enucleation of Intraductal Papillary Mucinous Neoplasm Located at the Pancreatic Head or Uncinate Process.
Soejima Y, Toshima T, Motomura T, Yokota T, Joko K, Oshiro Y, Takahashi I, Nishizaki T, Maehara Y
Anticancer Res 2017 Jan;37(1):321-326. doi: 10.21873/anticanres.11324. PMID: 28011509
Single-operator pancreatoscopy is helpful in the evaluation of suspected intraductal papillary mucinous neoplasms (IPMN).
Arnelo U, Siiki A, Swahn F, Segersvärd R, Enochsson L, del Chiaro M, Lundell L, Verbeke CS, Löhr JM
Pancreatology 2014 Nov-Dec;14(6):510-4. Epub 2014 Sep 27 doi: 10.1016/j.pan.2014.08.007. PMID: 25287157

Prognosis

Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.
Chang XY, Wu Y, Li Y, Wang J, Chen J
Mol Med Rep 2018 Jun;17(6):8061-8068. Epub 2018 Apr 12 doi: 10.3892/mmr.2018.8875. PMID: 29658583Free PMC Article
Intraductal papillary mucinous neoplasm of the pancreas rapidly xenografts in chicken eggs and predicts aggressiveness.
Zhao Z, Bauer N, Aleksandrowicz E, Yin L, Gladkich J, Gross W, Kaiser J, Hackert T, Strobel O, Herr I
Int J Cancer 2018 Apr 1;142(7):1440-1452. Epub 2017 Nov 29 doi: 10.1002/ijc.31160. PMID: 29143337Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Clinical prediction guides

Assessment of Malignancy Potential in Intraductal Papillary Mucinous Neoplasms of the Pancreas on MDCT.
Chai L, Zhu N, Wang Q, Wang T, Chai W
Acad Radiol 2021 May;28(5):679-686. Epub 2020 Jun 24 doi: 10.1016/j.acra.2020.03.042. PMID: 32591278
Preoperative risk prediction for intraductal papillary mucinous neoplasms by quantitative CT image analysis.
Attiyeh MA, Chakraborty J, Gazit L, Langdon-Embry L, Gonen M, Balachandran VP, D'Angelica MI, DeMatteo RP, Jarnagin WR, Kingham TP, Allen PJ, Do RK, Simpson AL
HPB (Oxford) 2019 Feb;21(2):212-218. Epub 2018 Aug 7 doi: 10.1016/j.hpb.2018.07.016. PMID: 30097414Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

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