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Parotid Gland Monomorphic Adenoma

MedGen UID:
277505
•Concept ID:
C1335362
•
Neoplastic Process
Synonym: Parotid monomorphic adenoma

Definition

A benign epithelial neoplasm that arises from the parotid gland. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Monomorphic Adenoma

Professional guidelines

PubMed

Treatment of relapses of benign latero-cervical pathology: a narrative literature review.
Meliante PG, Colizza A, Ralli M, Minni A, Angeletti D, Cambria F, de Vincentiis M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl 1):S76-S83. doi: 10.14639/0392-100X-suppl.1-43-2023-10. PMID: 37698104Free PMC Article
The differential diagnosis of parotid gland tumors with high-resolution ultrasound in otolaryngological practice.
Rzepakowska A, Osuch-Wójcikiewicz E, Sobol M, Cruz R, Sielska-Badurek E, Niemczyk K
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3231-3240. Epub 2017 Jun 13 doi: 10.1007/s00405-017-4636-2. PMID: 28612315Free PMC Article
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Adjuvant radiotherapy in parotid gland pleomorphic adenoma - recommendations.
Wierzbicka M, Fijuth J, Składowski K, Jurkiewicz D, Burduk P, Miłoński J, Niemczyk K, Pietruszewska W, Rogowski M, Stodulski D, Mikaszewski B
Otolaryngol Pol 2022 Sep 9;76(5):1-7. doi: 10.5604/01.3001.0015.9818. PMID: 36622124
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Functional gland-preserving surgery for submandibular gland pleomorphic adenoma.
Roh JL
J Cancer Res Clin Oncol 2022 Oct;148(10):2623-2629. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03844-8. PMID: 34705103
Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Pleomorphic adenoma of the parotid gland.
Middleton H, Strelow B
JAAPA 2022 Sep 1;35(9):54-56. doi: 10.1097/01.JAA.0000854504.04227.cf. PMID: 36007120
Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Pleomorphic Adenoma in the Parotid Gland.
Erickson LA
Mayo Clin Proc 2017 Mar;92(3):e55-e56. doi: 10.1016/j.mayocp.2017.01.006. PMID: 28259235
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195

Therapy

Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor.
Lee JY, Kim HJ, Kim YK, Cha J, Kim ST
Diagn Interv Radiol 2019 Jul;25(4):285-290. doi: 10.5152/dir.2019.18337. PMID: 31120425Free PMC Article
Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Proteomics analysis of pleomorphic adenoma of the human parotid gland.
Mutlu A, Ozturk M, Akpinar G, Kasap M, Kanli A
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3183-3195. Epub 2017 May 11 doi: 10.1007/s00405-017-4608-6. PMID: 28497265
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Basal Cell Adenoma of the Parotid Gland.
Amalanathan S , Kumar CS , Sinhasan SP
Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436. PMID: 34165108
Pleomorphic Adenoma of the Submandibular Gland: A Case Report.
Khanal P
JNMA J Nepal Med Assoc 2019 Jan-Feb;57(215):53-55. doi: 10.31729/jnma.4001. PMID: 31080247Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Clinical prediction guides

Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Histopathological comparison of pleomorphic adenomas of the parotid and submandibular gland.
Mantsopoulos K, Sievert M, Iro AK, Müller SK, Koch M, Schapher M, Agaimy A, Iro H
Oral Dis 2022 May;28(4):1131-1136. Epub 2021 Apr 5 doi: 10.1111/odi.13858. PMID: 33772981
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review.
de Carvalho Kimura T, de Lima-Souza RA, Scarini JF, Lavareze L, Egal ESA, Altemani A, Mariano FV
Head Neck 2023 Sep;45(9):2449-2457. Epub 2023 Jul 5 doi: 10.1002/hed.27435. PMID: 37403748
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368

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