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Parotid Gland Monomorphic Adenoma

MedGen UID:
277505
•Concept ID:
C1335362
•
Neoplastic Process
Synonym: Parotid monomorphic adenoma

Definition

A benign epithelial neoplasm that arises from the parotid gland. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Monomorphic Adenoma

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Management of parotid gland neoplasms.
Biörklund A, Eneroth CM
Am J Otolaryngol 1980 Feb;1(2):155-67. doi: 10.1016/s0196-0709(80)80011-1. PMID: 6255810

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Giant pleomorphic adenoma of the parotid gland: an unusual case presentation and literature review.
Tarsitano A, Pizzigallo A, Giorgini F, Marchetti C
Acta Otorhinolaryngol Ital 2015 Oct;35(4):293-6. PMID: 26824218Free PMC Article
Parotid gland tumors: a retrospective study of 154 patients.
Maahs GS, Oppermann Pde O, Maahs LG, Machado Filho G, Ronchi AD
Braz J Otorhinolaryngol 2015 May-Jun;81(3):301-6. Epub 2015 Mar 30 doi: 10.1016/j.bjorl.2015.03.007. PMID: 25934418Free PMC Article
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Diagnosis

Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Salivary gland pleomorphic adenoma.
Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2008 Feb;31(1):95-9. doi: 10.1097/COC.0b013e3181595ae0. PMID: 18376235
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Proteomics analysis of pleomorphic adenoma of the human parotid gland.
Mutlu A, Ozturk M, Akpinar G, Kasap M, Kanli A
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3183-3195. Epub 2017 May 11 doi: 10.1007/s00405-017-4608-6. PMID: 28497265
Salivary gland tumors in children: a retrospective clinical review.
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Sclerosing Polycystic Adenoma.
Bishop JA, Thompson LDR
Surg Pathol Clin 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004. PMID: 33526220
Basal Cell Adenoma of the Parotid Gland.
Amalanathan S , Kumar CS , Sinhasan SP
Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):434-436. PMID: 34165108
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Pleomorphic adenoma of the parotid.
Wolf JS, Goldberg AN, Bigelow DC
Am Fam Physician 1997 Jul;56(1):185-92. PMID: 9225674

Clinical prediction guides

Risk of Carcinoma in Pleomorphic Adenomas of the Parotid.
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review.
de Carvalho Kimura T, de Lima-Souza RA, Scarini JF, Lavareze L, Egal ESA, Altemani A, Mariano FV
Head Neck 2023 Sep;45(9):2449-2457. Epub 2023 Jul 5 doi: 10.1002/hed.27435. PMID: 37403748
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Benign parotid mass and facial palsy: systematic review.
Stewart KE, Bannon R, Bannister M
Ann R Coll Surg Engl 2021 Jan;103(1):47-52. Epub 2020 Sep 24 doi: 10.1308/rcsann.2020.0194. PMID: 32969265Free PMC Article

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