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Extrahepatic bile duct small cell adenocarcinoma

MedGen UID:
277648
Concept ID:
C1335979
Neoplastic Process
Synonyms: extrahepatic bile duct small cell adenocarcinoma; Extrahepatic Bile Duct Small Cell Carcinoma; Extrahepatic Bile Duct Small Cell NEC; extrahepatic bile duct small cell NEC; Extrahepatic Bile Duct Small Cell Neuroendocrine Carcinoma; extrahepatic bile duct small cell neuroendocrine carcinoma; Oat cell carcinoma of extrahepatic bile duct; Oat cell carcinoma of the extrahepatic bile duct; Oat cell extrahepatic bile duct carcinoma; Small Cell Adenocarcinoma of Extrahepatic Bile Duct; small cell adenocarcinoma of extrahepatic bile duct; Small Cell Adenocarcinoma of the Extrahepatic Bile Duct; small cell adenocarcinoma of the extrahepatic bile duct; Small Cell Extrahepatic Bile Duct Carcinoma; small cell extrahepatic bile duct carcinoma; Small Cell Extrahepatic Bile Duct Neuroendocrine Carcinoma; small cell extrahepatic bile duct neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0003708

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic bile duct small cell adenocarcinoma

Professional guidelines

PubMed

Sasaki M, Sato Y, Nakanuma Y
Pathol Res Pract 2024 Jan;253:155061. Epub 2023 Dec 22 doi: 10.1016/j.prp.2023.155061. PMID: 38154357
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP
Virchows Arch 2006 Apr;448(4):407-11. Epub 2006 Jan 13 doi: 10.1007/s00428-005-0145-6. PMID: 16411132

Recent clinical studies

Etiology

Nanjundappa RH, Christen U, Umeshappa CS
Hepatol Commun 2023 Sep 1;7(9) Epub 2023 Aug 9 doi: 10.1097/HC9.0000000000000218. PMID: 37555943Free PMC Article
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M, Thung SN
Semin Liver Dis 2011 Feb;31(1):49-60. Epub 2011 Feb 22 doi: 10.1055/s-0031-1272839. PMID: 21344350
Francis H, Alpini G, DeMorrow S
Am J Physiol Gastrointest Liver Physiol 2010 Jul;299(1):G1-9. Epub 2010 Apr 29 doi: 10.1152/ajpgi.00114.2010. PMID: 20430870Free PMC Article
Patel T
Nat Clin Pract Gastroenterol Hepatol 2006 Jan;3(1):33-42. doi: 10.1038/ncpgasthep0389. PMID: 16397610

Diagnosis

Han B, Seo YJ, Oh GH, You GR, Ma KY, Kim KH, Noh MG, Joo YE
Korean J Gastroenterol 2023 Mar 25;81(3):121-124. doi: 10.4166/kjg.2023.005. PMID: 36960694
Chang YC, Chen MH, Yeh CN, Hsiao M
Biomolecules 2020 Sep 28;10(10) doi: 10.3390/biom10101377. PMID: 32998289Free PMC Article
Lee HE, Zhang L
Semin Diagn Pathol 2019 Nov;36(6):423-433. Epub 2019 Jul 24 doi: 10.1053/j.semdp.2019.07.007. PMID: 31358425
Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M, Thung SN
Semin Liver Dis 2011 Feb;31(1):49-60. Epub 2011 Feb 22 doi: 10.1055/s-0031-1272839. PMID: 21344350
Patel T
Nat Clin Pract Gastroenterol Hepatol 2006 Jan;3(1):33-42. doi: 10.1038/ncpgasthep0389. PMID: 16397610

Therapy

Malik IA, Rajput M, Werner R, Fey D, Salehzadeh N, von Arnim CAF, Wilting J
BMC Cancer 2022 Nov 19;22(1):1193. doi: 10.1186/s12885-022-10247-6. PMID: 36402986Free PMC Article
Yoon JG, Kim MH, Jang M, Kim H, Hwang HK, Kang CM, Lee WJ, Kang B, Lee CK, Lee MG, Chung HC, Choi HJ, Park YN
Hepatology 2021 Oct;74(4):1914-1931. Epub 2021 Jul 29 doi: 10.1002/hep.31862. PMID: 33884649
Chang YC, Chen MH, Yeh CN, Hsiao M
Biomolecules 2020 Sep 28;10(10) doi: 10.3390/biom10101377. PMID: 32998289Free PMC Article
Kashima J, Okuma Y, Shimizuguchi R, Chiba K
Cancer Immunol Immunother 2018 Jan;67(1):61-65. Epub 2017 Sep 14 doi: 10.1007/s00262-017-2062-3. PMID: 28913619Free PMC Article
Rauws EA
Scand J Gastroenterol Suppl 2006;(243):135-8. doi: 10.1080/00365520600664441. PMID: 16782632

Prognosis

Deng M, Ran P, Chen L, Wang Y, Yu Z, Cai K, Feng J, Qin Z, Yin Y, Tan S, Liu Y, Xu C, Shi G, Ji Y, Zhao JY, Zhou J, Fan J, Hou Y, Ding C
Hepatology 2023 Feb 1;77(2):411-429. Epub 2022 Jul 5 doi: 10.1002/hep.32624. PMID: 35716043Free PMC Article
Chang YC, Chen MH, Yeh CN, Hsiao M
Biomolecules 2020 Sep 28;10(10) doi: 10.3390/biom10101377. PMID: 32998289Free PMC Article
Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M, Thung SN
Semin Liver Dis 2011 Feb;31(1):49-60. Epub 2011 Feb 22 doi: 10.1055/s-0031-1272839. PMID: 21344350
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080
Hartel M, Wente MN, Sido B, Friess H, Büchler MW
J Gastroenterol Hepatol 2005 May;20(5):676-81. doi: 10.1111/j.1440-1746.2005.03744.x. PMID: 15853978

Clinical prediction guides

Malik IA, Rajput M, Werner R, Fey D, Salehzadeh N, von Arnim CAF, Wilting J
BMC Cancer 2022 Nov 19;22(1):1193. doi: 10.1186/s12885-022-10247-6. PMID: 36402986Free PMC Article
Zhang L, Wan D, Bao L, Chen Q, Xie H, Xu S, Lin S
Medicine (Baltimore) 2018 Jul;97(29):e11487. doi: 10.1097/MD.0000000000011487. PMID: 30024526Free PMC Article
Walter D, Herrmann E, Schnitzbauer AA, Zeuzem S, Hansmann ML, Peveling-Oberhag J, Hartmann S
Histopathology 2017 Sep;71(3):383-392. Epub 2017 Jun 23 doi: 10.1111/his.13238. PMID: 28419539
Kobayashi M, Sakabe T, Abe H, Tanii M, Takahashi H, Chiba A, Yanagida E, Shibamoto Y, Ogasawara M, Tsujitani S, Koido S, Nagai K, Shimodaira S, Okamoto M, Yonemitsu Y, Suzuki N, Nagaya M; DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT)
J Gastrointest Surg 2013 Sep;17(9):1609-17. Epub 2013 Jul 20 doi: 10.1007/s11605-013-2286-2. PMID: 23877328
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

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