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Soft Palate Benign Granular Cell Tumor

MedGen UID:
277657
•Concept ID:
C1336019
•
Neoplastic Process
Synonyms: Benign Granular Cell Neoplasm of Soft Palate; Benign Granular Cell Neoplasm of the Soft Palate; Benign Granular Cell Tumor of Soft Palate; Benign Granular Cell Tumor of the Soft Palate; Soft Palate Benign Granular Cell Neoplasm

Definition

A granular cell tumor that arises from the soft palate and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSoft Palate Benign Granular Cell Tumor

Professional guidelines

PubMed

Oral cavity squamous cell carcinoma: role of pretreatment imaging and its influence on management.
Arya S, Rane P, Deshmukh A
Clin Radiol 2014 Sep;69(9):916-30. Epub 2014 Jun 5 doi: 10.1016/j.crad.2014.04.013. PMID: 24908285

Recent clinical studies

Etiology

The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy.
Bitz HC, Sachpazidis I, Zou J, Schnell D, Baltas D, Grosu AL, Nicolay NH, Rühle A
Radiat Oncol 2024 Apr 30;19(1):53. doi: 10.1186/s13014-024-02426-5. PMID: 38689338Free PMC Article
Application of prolonged submental perforator flap to repair the postoperative defect of upper airway malignancy.
Ma H, Zhong Q, Hou L, Feng L, He S, Lian M, Zhao Y, Wang R, Fang J
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5507-5518. Epub 2023 Aug 2 doi: 10.1007/s00405-023-08131-5. PMID: 37530858Free PMC Article
Techniques and outcomes in microsurgical soft palate reconstruction.
Fries CA, Al Deek N, Wei FC
Head Neck 2019 Jul;41(7):2085-2092. Epub 2019 Jan 28 doi: 10.1002/hed.25662. PMID: 30693590
Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study.
Alotaiby FM, Fitzpatrick S, Upadhyaya J, Islam MN, Cohen D, Bhattacharyya I
Head Neck Pathol 2019 Jun;13(2):208-214. Epub 2018 Jun 21 doi: 10.1007/s12105-018-0943-1. PMID: 29931661Free PMC Article
Child with mosaic variegated aneuploidy and embryonal rhabdomyosarcoma.
Limwongse C, Schwartz S, Bocian M, Robin NH
Am J Med Genet 1999 Jan 1;82(1):20-4. doi: 10.1002/(sici)1096-8628(19990101)82:1<20::aid-ajmg4>3.0.co;2-5. PMID: 9916837

Diagnosis

Can a diagnosis of Leiomyosarcoma soft palate be missed in the era of commoner oral carcinomas? - Rare case report and review of literature.
Kumar N, Gothwal RS, Lakhera KK, Chatterjee A, Singh S, Sharma RG, Patel P
J Cancer Res Ther 2023 Apr-Jun;19(3):835-838. doi: 10.4103/jcrt.jcrt_1024_21. PMID: 37470623
Multiple oral and cerebral relapses of a Granular cell tumor (Abrikossoff Tumor) in a young girl affected by congenital dyserythropoietic anemia type II.
Talarico V, Giancotti L, Mazza GA, Galea E, Arcuri PP, Raiola G, Galati MC, Tucci L, Miniero R
Clin Ter 2022 Feb 7;173(1):35-38. doi: 10.7417/CT.2022.2388. PMID: 35147644
Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study.
Alotaiby FM, Fitzpatrick S, Upadhyaya J, Islam MN, Cohen D, Bhattacharyya I
Head Neck Pathol 2019 Jun;13(2):208-214. Epub 2018 Jun 21 doi: 10.1007/s12105-018-0943-1. PMID: 29931661Free PMC Article
Leiomyosarcoma of maxilla: a case report with review of literature.
Gupta R, Astekar M, Dandriyal R, Bs M
J Exp Ther Oncol 2017 Sep;11(2):147-153. PMID: 28976138
Rhabdomyosarcoma of the oral and paraoral region.
Peters E, Cohen M, Altini M, Murray J
Cancer 1989 Mar 1;63(5):963-6. doi: 10.1002/1097-0142(19890301)63:5<963::aid-cncr2820630529>3.0.co;2-0. PMID: 2644020

Therapy

Transport osteogenesis in the maxillofacial skeleton: outcomes of a versatile reconstruction method following tumor ablation.
González-García R, Naval-Gías L
Arch Otolaryngol Head Neck Surg 2010 Mar;136(3):243-50. doi: 10.1001/archoto.2010.2. PMID: 20231641
The versatility of the free lateral arm flap in head and neck soft tissue reconstruction: clinical experience of 210 cases.
Marques Faria JC, Rodrigues ML, Scopel GP, Kowalski LP, Ferreira MC
J Plast Reconstr Aesthet Surg 2008;61(2):172-9. Epub 2007 Nov 26 doi: 10.1016/j.bjps.2007.10.035. PMID: 18042444
Squamous cell carcinoma of the oral mucosa after release of submucous fibrosis and bilateral small radial forearm flap reconstruction.
Celik N, Wei FC, Chang YM, Yang WG, Chen DJ, Tsai CY
Plast Reconstr Surg 2002 Jul;110(1):34-8. doi: 10.1097/00006534-200207000-00008. PMID: 12087228
Variability in the Michelin tire syndrome. A child with multiple anomalies, smooth muscle hamartoma, and familial paracentric inversion of chromosome 7q.
Schnur RE, Herzberg AJ, Spinner N, Kant JA, Magnusson M, McDonald-McGinn D, Rehberg K, Honig PJ, Zackai EH
J Am Acad Dermatol 1993 Feb;28(2 Pt 2):364-70. PMID: 8436660
Rhabdomyoma of the soft palate. Fine structural details of a highly differentiated muscle tumor.
Böck D, Böck P
Histol Histopathol 1987 Jul;2(3):285-9. PMID: 2980731

Prognosis

The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy.
Bitz HC, Sachpazidis I, Zou J, Schnell D, Baltas D, Grosu AL, Nicolay NH, Rühle A
Radiat Oncol 2024 Apr 30;19(1):53. doi: 10.1186/s13014-024-02426-5. PMID: 38689338Free PMC Article
Oral cavity squamous cell carcinoma: role of pretreatment imaging and its influence on management.
Arya S, Rane P, Deshmukh A
Clin Radiol 2014 Sep;69(9):916-30. Epub 2014 Jun 5 doi: 10.1016/j.crad.2014.04.013. PMID: 24908285
Tumors of the oral cavity and pharynx.
Wertheimer-Hatch L, Hatch GF 3rd, HatchB S KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):395-400. doi: 10.1007/s002689910064. PMID: 10706911
Rhabdomyosarcoma of the oral and paraoral region.
Peters E, Cohen M, Altini M, Murray J
Cancer 1989 Mar 1;63(5):963-6. doi: 10.1002/1097-0142(19890301)63:5<963::aid-cncr2820630529>3.0.co;2-0. PMID: 2644020
Intraoral rhabdomyomas.
Corio RL, Lewis DM
Oral Surg Oral Med Oral Pathol 1979 Dec;48(6):525-31. doi: 10.1016/0030-4220(79)90299-8. PMID: 292957

Clinical prediction guides

The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy.
Bitz HC, Sachpazidis I, Zou J, Schnell D, Baltas D, Grosu AL, Nicolay NH, Rühle A
Radiat Oncol 2024 Apr 30;19(1):53. doi: 10.1186/s13014-024-02426-5. PMID: 38689338Free PMC Article
Application of prolonged submental perforator flap to repair the postoperative defect of upper airway malignancy.
Ma H, Zhong Q, Hou L, Feng L, He S, Lian M, Zhao Y, Wang R, Fang J
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5507-5518. Epub 2023 Aug 2 doi: 10.1007/s00405-023-08131-5. PMID: 37530858Free PMC Article
Techniques and outcomes in microsurgical soft palate reconstruction.
Fries CA, Al Deek N, Wei FC
Head Neck 2019 Jul;41(7):2085-2092. Epub 2019 Jan 28 doi: 10.1002/hed.25662. PMID: 30693590
Angioleiomyoma affecting the lips: report of 3 cases and review of the literature.
Gueiros LA, Romañach MJ, Pires-Soubhia AM, Pires FR, Paes-de-Almeida O, Vargas PA
Med Oral Patol Oral Cir Bucal 2011 Jul 1;16(4):e482-7. doi: 10.4317/medoral.16.e482. PMID: 20526260
The versatility of the free lateral arm flap in head and neck soft tissue reconstruction: clinical experience of 210 cases.
Marques Faria JC, Rodrigues ML, Scopel GP, Kowalski LP, Ferreira MC
J Plast Reconstr Aesthet Surg 2008;61(2):172-9. Epub 2007 Nov 26 doi: 10.1016/j.bjps.2007.10.035. PMID: 18042444

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