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Penile Squamous Cell Carcinoma, Usual Type

MedGen UID:
277667
•Concept ID:
C1336081
•
Neoplastic Process
Synonyms: Squamous Cell Carcinoma of Penis, Usual Type; Squamous Cell Carcinoma of the Penis, Usual Type

Definition

A squamous cell carcinoma that arises from the penis and cannot be classified according to other morphologic subtypes. [from NCI]

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Histologic classification of penile intraepithelial neoplasia.
Velazquez EF, Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):96-102. doi: 10.1053/j.semdp.2011.08.009. PMID: 22641959
The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinomas.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):67-71. doi: 10.1053/j.semdp.2011.09.001. PMID: 22641955
The prognostic value of Ki-67 expression in penile squamous cell carcinoma.
Stankiewicz E, Ng M, Cuzick J, Mesher D, Watkin N, Lam W, Corbishley C, Berney DM
J Clin Pathol 2012 Jun;65(6):534-7. Epub 2012 Mar 23 doi: 10.1136/jclinpath-2011-200638. PMID: 22447920
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964

Diagnosis

New pathologic entities in penile carcinomas: an update of the 2004 world health organization classification.
Chaux A, Velazquez EF, Barreto JE, Ayala E, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):59-66. doi: 10.1053/j.semdp.2011.06.001. PMID: 22641954
The prognostic value of Ki-67 expression in penile squamous cell carcinoma.
Stankiewicz E, Ng M, Cuzick J, Mesher D, Watkin N, Lam W, Corbishley C, Berney DM
J Clin Pathol 2012 Jun;65(6):534-7. Epub 2012 Mar 23 doi: 10.1136/jclinpath-2011-200638. PMID: 22447920
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients.
Cunha IW, Guimaraes GC, Soares F, Velazquez E, Torres JJ, Chaux A, Ayala G, Cubilla AL
Am J Surg Pathol 2009 Apr;33(4):551-5. doi: 10.1097/PAS.0b013e31818a01d8. PMID: 19033863
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinomas.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):67-71. doi: 10.1053/j.semdp.2011.09.001. PMID: 22641955
New pathologic entities in penile carcinomas: an update of the 2004 world health organization classification.
Chaux A, Velazquez EF, Barreto JE, Ayala E, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):59-66. doi: 10.1053/j.semdp.2011.06.001. PMID: 22641954
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Clinical prediction guides

Prognostic utility of SOX2, STAT3, and CD44(high)/CD24(low) expression in penile cancer.
de Barros FD, Torres LC, Araujo C, da Silva Marinho F, Dubourcq BC, Dubourcq LC, Guimarães GC
J Cancer Res Clin Oncol 2023 May;149(5):2081-2094. Epub 2022 Aug 1 doi: 10.1007/s00432-022-04222-8. PMID: 35913637
Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: Fox-P3 expression is an independent predictor of recurrence.
Vassallo J, Rodrigues AF, Campos AH, Rocha RM, da Cunha IW, Zequi SC, Guimarães GC, da Fonseca FP, Lopes A, Cubilla A, Soares FA
Tumour Biol 2015 Apr;36(4):2509-16. Epub 2015 Jan 5 doi: 10.1007/s13277-014-2864-2. PMID: 25557886
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL
J Urol 2009 Aug;182(2):528-34; discussion 534. Epub 2009 Jun 13 doi: 10.1016/j.juro.2009.04.028. PMID: 19524964
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901
Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases.
Velazquez EF, Soskin A, Bock A, Codas R, Cai G, Barreto JE, Cubilla AL
Mod Pathol 2005 Jul;18(7):917-23. doi: 10.1038/modpathol.3800371. PMID: 15920559

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