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Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 3

MedGen UID:
277771
•Concept ID:
C1336509
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStoriform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 3

Professional guidelines

PubMed

Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy.
Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP
Cancer 2014 Dec 1;120(23):3676-82. Epub 2014 Jul 31 doi: 10.1002/cncr.28945. PMID: 25081640Free PMC Article
Preoperative vs. postoperative radiotherapy in the treatment of soft tissue sarcomas: a matter of presentation.
Pollack A, Zagars GK, Goswitz MS, Pollock RA, Feig BW, Pisters PW
Int J Radiat Oncol Biol Phys 1998 Oct 1;42(3):563-72. doi: 10.1016/s0360-3016(98)00277-6. PMID: 9806516

Recent clinical studies

Etiology

ALK-rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors.
Dermawan JK, DiNapoli SE, Mullaney KA, Sukhadia P, Agaram NP, Dickson BC, Antonescu CR
Genes Chromosomes Cancer 2023 Feb;62(2):75-84. Epub 2022 Oct 7 doi: 10.1002/gcc.23097. PMID: 36125853Free PMC Article
Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy.
Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP
Cancer 2014 Dec 1;120(23):3676-82. Epub 2014 Jul 31 doi: 10.1002/cncr.28945. PMID: 25081640Free PMC Article
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients: the St. Jude Children's Research Hospital experience.
Daw NC, Billups CA, Pappo AS, Jenkins JJ, Mahmoud HH, Krasin MJ, Rao BN
Cancer 2003 Jun 1;97(11):2839-47. doi: 10.1002/cncr.11384. PMID: 12767098
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

Diagnosis

Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients: the St. Jude Children's Research Hospital experience.
Daw NC, Billups CA, Pappo AS, Jenkins JJ, Mahmoud HH, Krasin MJ, Rao BN
Cancer 2003 Jun 1;97(11):2839-47. doi: 10.1002/cncr.11384. PMID: 12767098
Postoperative nomogram for 12-year sarcoma-specific death.
Kattan MW, Leung DH, Brennan MF
J Clin Oncol 2002 Feb 1;20(3):791-6. doi: 10.1200/JCO.2002.20.3.791. PMID: 11821462
Metastatic nonrhabdomyosarcomatous soft-tissue sarcomas in children and adolescents: the St. Jude Children's Research Hospital experience.
Pappo AS, Rao BN, Jenkins JJ, Merchant T, Poquette CA, Cain A, Pratt CB
Med Pediatr Oncol 1999 Aug;33(2):76-82. doi: 10.1002/(sici)1096-911x(199908)33:2<76::aid-mpo3>3.0.co;2-b. PMID: 10398180
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580
Limb salvage surgery for bone and soft tissue sarcoma. A phase II pathologic study of preoperative intraarterial cisplatin.
Kempf RA, Irwin LE, Menendez L, Chandrasoma P, Groshen S, Melbye W, Moore T, Pentecost M, Quinn M, Sapozink M
Cancer 1991 Aug 15;68(4):738-43. doi: 10.1002/1097-0142(19910815)68:4<738::aid-cncr2820680413>3.0.co;2-j. PMID: 1855173

Therapy

Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions.
Dineen SP, Roland CL, Feig R, May C, Zhou S, Demicco E, Sannaa GA, Ingram D, Wang WL, Ravi V, Guadagnolo A, Lev D, Pollock RE, Hunt K, Cormier J, Lazar A, Feig B, Torres KE
Ann Surg Oncol 2015 Nov;22(12):3913-20. Epub 2015 Mar 6 doi: 10.1245/s10434-015-4453-z. PMID: 25743327Free PMC Article
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas?
Gladdy RA, Qin LX, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, Brennan MF, Singer S
J Clin Oncol 2010 Apr 20;28(12):2064-9. Epub 2010 Mar 22 doi: 10.1200/JCO.2009.25.1728. PMID: 20308666Free PMC Article
Postoperative nomogram for 12-year sarcoma-specific death.
Kattan MW, Leung DH, Brennan MF
J Clin Oncol 2002 Feb 1;20(3):791-6. doi: 10.1200/JCO.2002.20.3.791. PMID: 11821462
Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma.
Casper ES, Christman KL, Schwartz GK, Johnson B, Brennan MF, Bertino JR
Cancer 1993 Aug 1;72(3):766-70. doi: 10.1002/1097-0142(19930801)72:3<766::aid-cncr2820720321>3.0.co;2-z. PMID: 8392904

Prognosis

Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy.
Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP
Cancer 2014 Dec 1;120(23):3676-82. Epub 2014 Jul 31 doi: 10.1002/cncr.28945. PMID: 25081640Free PMC Article
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas?
Gladdy RA, Qin LX, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, Brennan MF, Singer S
J Clin Oncol 2010 Apr 20;28(12):2064-9. Epub 2010 Mar 22 doi: 10.1200/JCO.2009.25.1728. PMID: 20308666Free PMC Article
Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients: the St. Jude Children's Research Hospital experience.
Daw NC, Billups CA, Pappo AS, Jenkins JJ, Mahmoud HH, Krasin MJ, Rao BN
Cancer 2003 Jun 1;97(11):2839-47. doi: 10.1002/cncr.11384. PMID: 12767098
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

Clinical prediction guides

Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions.
Dineen SP, Roland CL, Feig R, May C, Zhou S, Demicco E, Sannaa GA, Ingram D, Wang WL, Ravi V, Guadagnolo A, Lev D, Pollock RE, Hunt K, Cormier J, Lazar A, Feig B, Torres KE
Ann Surg Oncol 2015 Nov;22(12):3913-20. Epub 2015 Mar 6 doi: 10.1245/s10434-015-4453-z. PMID: 25743327Free PMC Article
Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas?
Gladdy RA, Qin LX, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, Brennan MF, Singer S
J Clin Oncol 2010 Apr 20;28(12):2064-9. Epub 2010 Mar 22 doi: 10.1200/JCO.2009.25.1728. PMID: 20308666Free PMC Article
Postoperative nomogram for 12-year sarcoma-specific death.
Kattan MW, Leung DH, Brennan MF
J Clin Oncol 2002 Feb 1;20(3):791-6. doi: 10.1200/JCO.2002.20.3.791. PMID: 11821462
Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma.
Casper ES, Christman KL, Schwartz GK, Johnson B, Brennan MF, Bertino JR
Cancer 1993 Aug 1;72(3):766-70. doi: 10.1002/1097-0142(19930801)72:3<766::aid-cncr2820720321>3.0.co;2-z. PMID: 8392904
Adult urological sarcoma.
Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, Brennan MF
J Urol 1992 Apr;147(4):1032-6; discussion 1036-7. doi: 10.1016/s0022-5347(17)37456-6. PMID: 1552580

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