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Differentiated thyroid carcinoma

MedGen UID:
277876
Concept ID:
C1337013
Neoplastic Process
Synonyms: Differentiated thyroid cancer; Differentiated Thyroid Cancer; differentiated thyroid cancer; Differentiated Thyroid Carcinoma; differentiated thyroid carcinoma; differentiated thyroid gland cancer; Differentiated Thyroid Gland Carcinoma; differentiated thyroid gland carcinoma; DTC - differentiated thyroid cancer; Follicular/Papillary Thyroid Gland Carcinoma; Papillary or follicular thyroid carcinoma; papillary or follicular thyroid carcinoma; Thyroid Gland Differentiated Carcinoma; thyroid gland differentiated carcinoma; Thyroid Gland Well Differentiated Carcinoma; thyroid gland well differentiated carcinoma; Well Differentiated Thyroid Carcinoma; well differentiated thyroid carcinoma; Well Differentiated Thyroid Gland Carcinoma; well differentiated thyroid gland carcinoma; Well-Differentiated Thyroid Cancer; well-differentiated thyroid cancer; Well-differentiated thyroid carcinoma; well-differentiated thyroid carcinoma
SNOMED CT: DTC - differentiated thyroid cancer (1255086008); Differentiated thyroid cancer (1255086008); Differentiated thyroid carcinoma (1255086008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015447
Orphanet: ORPHA146

Definition

A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferentiated thyroid carcinoma

Professional guidelines

PubMed

Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Nishino M
Semin Diagn Pathol 2020 Sep;37(5):211-212. Epub 2020 Aug 5 doi: 10.1053/j.semdp.2020.07.004. PMID: 32782166
Soh SB, Aw TC
Ann Lab Med 2019 Jan;39(1):3-14. doi: 10.3343/alm.2019.39.1.3. PMID: 30215224Free PMC Article

Recent clinical studies

Etiology

Abou Jokh Casas E, Repetto A, Rodriguez Gasén A, Vercher Conejero JL, Bello Arques P, Cambil Molina T, Vallejo Casas JA
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):325-334. Epub 2023 Jul 11 doi: 10.1016/j.remnie.2023.07.003. PMID: 37442524
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Diagnosis

Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Canberk S, Thodou E, Bongiovanni M
Acta Cytol 2022;66(4):307-318. Epub 2022 Jan 11 doi: 10.1159/000520876. PMID: 35016187
Crockett DJ, Faucett EA, Gnagi SH
Pediatr Ann 2021 Jul;50(7):e282-e285. Epub 2021 Jul 1 doi: 10.3928/19382359-20210621-01. PMID: 34264794
Nishino M
Semin Diagn Pathol 2020 Sep;37(5):211-212. Epub 2020 Aug 5 doi: 10.1053/j.semdp.2020.07.004. PMID: 32782166
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274

Therapy

Abou Jokh Casas E, Repetto A, Rodriguez Gasén A, Vercher Conejero JL, Bello Arques P, Cambil Molina T, Vallejo Casas JA
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):325-334. Epub 2023 Jul 11 doi: 10.1016/j.remnie.2023.07.003. PMID: 37442524
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Zhao Q, Feng H, Yang Z, Liang J, Jin Z, Chen L, Zhan L, Xuan M, Yan J, Kuang J, Cheng X, Zhao R, Qiu W
Clin Transl Med 2022 Feb;12(2):e727. doi: 10.1002/ctm2.727. PMID: 35184413Free PMC Article
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Grani G, Ramundo V, Verrienti A, Sponziello M, Durante C
Endocrine 2019 Oct;66(1):43-50. Epub 2019 Oct 15 doi: 10.1007/s12020-019-02051-3. PMID: 31617165

Prognosis

San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
Park JH, Yoon JH
Endocr Relat Cancer 2019 Jul;26(7):R381-R393. doi: 10.1530/ERC-19-0085. PMID: 31018176
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403
Byrd JK, Yawn RJ, Wilhoit CS, Sora ND, Meyers L, Fernandes J, Day T
Curr Treat Options Oncol 2012 Mar;13(1):47-57. doi: 10.1007/s11864-011-0173-1. PMID: 22234582

Clinical prediction guides

Matsuse M, Mitsutake N
Endocr J 2023 Nov 28;70(11):1035-1049. Epub 2023 Aug 1 doi: 10.1507/endocrj.EJ23-0136. PMID: 37532521
Cellini M, Rotondi M, Tanda ML, Piantanida E, Chiovato L, Beck-Peccoz P, Lania A, Mazziotti G
J Endocrinol Invest 2021 Mar;44(3):431-442. Epub 2020 Jul 21 doi: 10.1007/s40618-020-01359-6. PMID: 32696339
Sasanakietkul T, Murtha TD, Javid M, Korah R, Carling T
Mol Cell Endocrinol 2018 Jul 5;469:23-37. Epub 2017 May 25 doi: 10.1016/j.mce.2017.05.022. PMID: 28552796
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Recent systematic reviews

Monos S, Fritz C, Harris J, Romeo D, Ng JJ, Xu K, Cooperberg B, Moreira A, Rajasekaran K
Otolaryngol Head Neck Surg 2024 Jan;170(1):20-33. Epub 2023 Sep 11 doi: 10.1002/ohn.508. PMID: 37694597
San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck 2016 Apr;38 Suppl 1:E2297-305. Epub 2015 Sep 3 doi: 10.1002/hed.24218. PMID: 26335228
Lang BH, Wong CK, Tsang JS, Wong KP, Wan KY
Laryngoscope 2015 Feb;125(2):509-18. Epub 2014 Sep 19 doi: 10.1002/lary.24946. PMID: 25236330
Madenci AL, Caragacianu D, Boeckmann JO, Stack BC Jr, Shin JJ
Laryngoscope 2014 Jul;124(7):1724-34. Epub 2014 Feb 10 doi: 10.1002/lary.24583. PMID: 24390830

Supplemental Content

Table of contents

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