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Differentiated thyroid carcinoma

MedGen UID:
277876
•Concept ID:
C1337013
•
Neoplastic Process
Synonyms: Differentiated thyroid cancer; Differentiated Thyroid Cancer; differentiated thyroid cancer; Differentiated Thyroid Carcinoma; differentiated thyroid carcinoma; differentiated thyroid gland cancer; Differentiated Thyroid Gland Carcinoma; differentiated thyroid gland carcinoma; DTC - differentiated thyroid cancer; Follicular/Papillary Thyroid Gland Carcinoma; Papillary or follicular thyroid carcinoma; papillary or follicular thyroid carcinoma; Thyroid Gland Differentiated Carcinoma; thyroid gland differentiated carcinoma; Thyroid Gland Well Differentiated Carcinoma; thyroid gland well differentiated carcinoma; Well Differentiated Thyroid Carcinoma; well differentiated thyroid carcinoma; Well Differentiated Thyroid Gland Carcinoma; well differentiated thyroid gland carcinoma; Well-Differentiated Thyroid Cancer; well-differentiated thyroid cancer; Well-differentiated thyroid carcinoma; well-differentiated thyroid carcinoma
SNOMED CT: DTC - differentiated thyroid cancer (1255086008); Differentiated thyroid cancer (1255086008); Differentiated thyroid carcinoma (1255086008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015447
Orphanet: ORPHA146

Definition

A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferentiated thyroid carcinoma

Professional guidelines

PubMed

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility.
Soh SB, Aw TC
Ann Lab Med 2019 Jan;39(1):3-14. doi: 10.3343/alm.2019.39.1.3. PMID: 30215224Free PMC Article

Recent clinical studies

Etiology

Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Development and validation of a nomogram model for cancer-specific survival of patients with poorly differentiated thyroid carcinoma: A SEER database analysis.
Jin S, Liu H, Yang J, Zhou J, Peng D, Liu X, Zhang H, Zeng Z, Ye YN
Front Endocrinol (Lausanne) 2022;13:882279. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.882279. PMID: 36176465Free PMC Article
A seven-autophagy-related gene signature for predicting the prognosis of differentiated thyroid carcinoma.
Li C, Yuan Q, Xu G, Yang Q, Hou J, Zheng L, Wu G
World J Surg Oncol 2022 Apr 23;20(1):129. doi: 10.1186/s12957-022-02590-6. PMID: 35459137Free PMC Article
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Thyroid hormone therapy in differentiated thyroid cancer.
Grani G, Ramundo V, Verrienti A, Sponziello M, Durante C
Endocrine 2019 Oct;66(1):43-50. Epub 2019 Oct 15 doi: 10.1007/s12020-019-02051-3. PMID: 31617165

Diagnosis

Advances in Thyroid Pathology: High Grade Follicular Cell-derived Thyroid Carcinoma and Anaplastic Thyroid Carcinoma.
Xu B, Ghossein RA
Adv Anat Pathol 2023 Jan 1;30(1):3-10. Epub 2022 Oct 24 doi: 10.1097/PAP.0000000000000380. PMID: 36306188
Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer.
Li S, Ren C, Gong Y, Ye F, Tang Y, Xu J, Guo C, Huang J
Front Endocrinol (Lausanne) 2022;13:872527. Epub 2022 Jun 2 doi: 10.3389/fendo.2022.872527. PMID: 35721746Free PMC Article
Thyroid Nodule/Differentiated Thyroid Carcinoma in the Pediatric Population.
Crockett DJ, Faucett EA, Gnagi SH
Pediatr Ann 2021 Jul;50(7):e282-e285. Epub 2021 Jul 1 doi: 10.3928/19382359-20210621-01. PMID: 34264794
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274

Therapy

Development and validation of a nomogram model for cancer-specific survival of patients with poorly differentiated thyroid carcinoma: A SEER database analysis.
Jin S, Liu H, Yang J, Zhou J, Peng D, Liu X, Zhang H, Zeng Z, Ye YN
Front Endocrinol (Lausanne) 2022;13:882279. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.882279. PMID: 36176465Free PMC Article
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer.
Zhao Q, Feng H, Yang Z, Liang J, Jin Z, Chen L, Zhan L, Xuan M, Yan J, Kuang J, Cheng X, Zhao R, Qiu W
Clin Transl Med 2022 Feb;12(2):e727. doi: 10.1002/ctm2.727. PMID: 35184413Free PMC Article
Thyroid hormone therapy in differentiated thyroid cancer.
Grani G, Ramundo V, Verrienti A, Sponziello M, Durante C
Endocrine 2019 Oct;66(1):43-50. Epub 2019 Oct 15 doi: 10.1007/s12020-019-02051-3. PMID: 31617165
NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.
Haddad RI, Nasr C, Bischoff L, Busaidy NL, Byrd D, Callender G, Dickson P, Duh QY, Ehya H, Goldner W, Haymart M, Hoh C, Hunt JP, Iagaru A, Kandeel F, Kopp P, Lamonica DM, McIver B, Raeburn CD, Ridge JA, Ringel MD, Scheri RP, Shah JP, Sippel R, Smallridge RC, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Johnson-Chilla A, Hoffmann KG, Gurski LA
J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440. doi: 10.6004/jnccn.2018.0089. PMID: 30545990

Prognosis

Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma.
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
Lobectomy in patients with differentiated thyroid cancer: indications and follow-up.
Park JH, Yoon JH
Endocr Relat Cancer 2019 Jul;26(7):R381-R393. doi: 10.1530/ERC-19-0085. PMID: 31018176
Recurrent well-differentiated thyroid carcinoma.
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403
Prognostic factors for differentiated thyroid carcinoma and review of the literature.
Zhao Y, Zhang Y, Liu XJ, Shi BY
Tumori 2012 Mar-Apr;98(2):233-7. doi: 10.1177/030089161209800209. PMID: 22677990
Well-differentiated thyroid carcinoma.
Segal K, Raveh E, Lubin E, Abraham A, Shvero J, Feinmesser R
Am J Otolaryngol 1996 Nov-Dec;17(6):401-6. doi: 10.1016/s0196-0709(96)90074-5. PMID: 8944300

Clinical prediction guides

Development and validation of a nomogram model for cancer-specific survival of patients with poorly differentiated thyroid carcinoma: A SEER database analysis.
Jin S, Liu H, Yang J, Zhou J, Peng D, Liu X, Zhang H, Zeng Z, Ye YN
Front Endocrinol (Lausanne) 2022;13:882279. Epub 2022 Sep 13 doi: 10.3389/fendo.2022.882279. PMID: 36176465Free PMC Article
A seven-autophagy-related gene signature for predicting the prognosis of differentiated thyroid carcinoma.
Li C, Yuan Q, Xu G, Yang Q, Hou J, Zheng L, Wu G
World J Surg Oncol 2022 Apr 23;20(1):129. doi: 10.1186/s12957-022-02590-6. PMID: 35459137Free PMC Article
Skeletal health in patients with differentiated thyroid carcinoma.
Cellini M, Rotondi M, Tanda ML, Piantanida E, Chiovato L, Beck-Peccoz P, Lania A, Mazziotti G
J Endocrinol Invest 2021 Mar;44(3):431-442. Epub 2020 Jul 21 doi: 10.1007/s40618-020-01359-6. PMID: 32696339
Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Recurrent well-differentiated thyroid carcinoma.
Magarey MJ, Freeman JL
Oral Oncol 2013 Jul;49(7):689-94. Epub 2013 Apr 25 doi: 10.1016/j.oraloncology.2013.03.434. PMID: 23623403

Recent systematic reviews

Incidence, Recurrence and Mortality Among Filipinos With Differentiated Thyroid Cancer: A Systematic Review.
San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
Health-Related Quality of Life following Total Thyroidectomy and Lobectomy for Differentiated Thyroid Carcinoma: A Systematic Review.
Landry V, Siciliani E, Henry M, Payne RJ
Curr Oncol 2022 Jun 21;29(7):4386-4422. doi: 10.3390/curroncol29070350. PMID: 35877210Free PMC Article
The Effect of Radioactive Iodine Therapy on Ovarian Function and Fertility in Female Thyroid Cancer Patients: A Systematic Review and Meta-Analysis.
Piek MW, Postma EL, van Leeuwaarde R, de Boer JP, Bos AME, Lok C, Stokkel M, Filipe MD, van der Ploeg IMC
Thyroid 2021 Apr;31(4):658-668. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0356. PMID: 33012254
External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck 2016 Apr;38 Suppl 1:E2297-305. Epub 2015 Sep 3 doi: 10.1002/hed.24218. PMID: 26335228
Lateral neck dissection for well-differentiated thyroid carcinoma: a systematic review.
Madenci AL, Caragacianu D, Boeckmann JO, Stack BC Jr, Shin JJ
Laryngoscope 2014 Jul;124(7):1724-34. Epub 2014 Feb 10 doi: 10.1002/lary.24583. PMID: 24390830

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