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Mature teratoma

MedGen UID:
277967
•Concept ID:
C1368910
•
Neoplastic Process
Synonyms: Grade 0 Teratoma; Mature Teratoma; mature teratoma
SNOMED CT: Mature teratoma (42717009)
 
Monarch Initiative: MONDO:0003517

Definition

A teratoma which may be cystic; it is composed entirely of well differentiated, adult-type mature tissues, without evidence of fetal-type immature tissues (grade 0 teratoma). [from NCI]

Professional guidelines

PubMed

Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Management of residual masses in testicular germ cell tumors.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Expert Rev Anticancer Ther 2019 Apr;19(4):291-300. Epub 2019 Feb 22 doi: 10.1080/14737140.2019.1580146. PMID: 30793990
Clinical management of teratoma, a rare hypothalamic-pituitary neoplasia.
Chiloiro S, Giampietro A, Bianchi A, De Marinis L
Endocrine 2016 Sep;53(3):636-42. Epub 2015 Dec 23 doi: 10.1007/s12020-015-0814-4. PMID: 26701679

Recent clinical studies

Etiology

Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Ovarian torsion.
Cass DL
Semin Pediatr Surg 2005 May;14(2):86-92. doi: 10.1053/j.sempedsurg.2005.01.003. PMID: 15846564

Diagnosis

Mature Orbital Teratoma.
Chaudhry R, Qamar MN, Riaz A
J Coll Physicians Surg Pak 2021 May;30(5):596-598. doi: 10.29271/jcpsp.2021.05.596. PMID: 34027878
Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Mature ovarian cystic teratoma with a highly differentiated homunculus: a case report.
Kuno N, Kadomatsu K, Nakamura M, Miwa-Fukuchi T, Hirabayashi N, Ishizuka T
Birth Defects Res A Clin Mol Teratol 2004 Jan;70(1):40-6. doi: 10.1002/bdra.10133. PMID: 14745894

Therapy

Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Management of residual masses in testicular germ cell tumors.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Expert Rev Anticancer Ther 2019 Apr;19(4):291-300. Epub 2019 Feb 22 doi: 10.1080/14737140.2019.1580146. PMID: 30793990
Growing teratoma syndrome after ovarian inmature teratoma: a case report and review of the literature.
Lapuente-Ocamica O, Ugarte L, Cuadra M, Lopez-Picado A, Maestro L, Lete I
Clin Exp Obstet Gynecol 2016;43(6):905-910. PMID: 29944251
Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.
Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR
Ann Neurol 2007 Jan;61(1):25-36. doi: 10.1002/ana.21050. PMID: 17262855Free PMC Article
Excision of mature teratoma using culdotomy, with and without laparoscopy: a prospective randomised trial.
Wang PH, Lee WL, Juang CM, Tsai WY, Chao HT, Yuan CC
BJOG 2001 Jan;108(1):91-4. doi: 10.1111/j.1471-0528.2001.00003.x. PMID: 11213011

Prognosis

Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Primary ovarian neuroblastoma.
Muhlstein J, Rodriguez-Dahlhoff S, Marie B, Fouyssac F
J Pediatr Adolesc Gynecol 2010 Oct;23(5):263-6. Epub 2010 Apr 3 doi: 10.1016/j.jpag.2010.01.005. PMID: 20371194
Tumors of the thymus.
Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501
Neonatal intracranial teratomas.
Hunt SJ, Johnson PC, Coons SW, Pittman HW
Surg Neurol 1990 Nov;34(5):336-42. doi: 10.1016/0090-3019(90)90011-d. PMID: 2218855

Clinical prediction guides

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
CT and MRI characteristics of ovarian mature teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis.
Kawaguchi M, Kato H, Noda Y, Suzui N, Miyazaki T, Furui T, Morishige KI, Matsuo M
Diagn Interv Imaging 2021 Jul-Aug;102(7-8):447-453. Epub 2021 Mar 27 doi: 10.1016/j.diii.2021.02.010. PMID: 33785312
Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours.
Almstrup K, Lobo J, Mørup N, Belge G, Rajpert-De Meyts E, Looijenga LHJ, Dieckmann KP
Nat Rev Urol 2020 Apr;17(4):201-213. Epub 2020 Mar 10 doi: 10.1038/s41585-020-0296-x. PMID: 32157202
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Mature ovarian cystic teratoma with a highly differentiated homunculus: a case report.
Kuno N, Kadomatsu K, Nakamura M, Miwa-Fukuchi T, Hirabayashi N, Ishizuka T
Birth Defects Res A Clin Mol Teratol 2004 Jan;70(1):40-6. doi: 10.1002/bdra.10133. PMID: 14745894

Recent systematic reviews

Cervical intramedullary teratoma: a case report and systematic review of the literature.
Palacio-Uribe L, Perez-Roman RJ, Bryant JP, Brathwaite C, Pacheco-Jácome E, Niazi T
Childs Nerv Syst 2022 May;38(5):997-1004. Epub 2021 Oct 21 doi: 10.1007/s00381-021-05385-4. PMID: 34676426
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Testis-sparing surgery for testicular tumors in children: a 20 year single center experience and systematic review of the literature.
Bois JI, Vagni RL, de Badiola FI, Moldes JM, Losty PD, Lobos PA
Pediatr Surg Int 2021 May;37(5):607-616. Epub 2021 Jan 17 doi: 10.1007/s00383-020-04850-6. PMID: 33454815
Clinical Characteristics and Surgical Management of Adult Adrenal Teratoma: A 15-year Experience and Systematic Review of the Literature.
Zhong W, Ma R, Cheng S, Tian J, Wang H, Wang T, Zhang Z, Li X, Lu J, Ma L, Zhou L
Urology 2020 Jan;135:71-75. Epub 2019 Jun 10 doi: 10.1016/j.urology.2019.05.032. PMID: 31195014

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