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NMYC Gene Amplification

MedGen UID:
279377
•Concept ID:
C1522020
•
Cell or Molecular Dysfunction
Synonyms: MYCN Gene Amplification; N-myc Gene Amplification; Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene Amplification; V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the MYCN gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNMYC Gene Amplification

Professional guidelines

PubMed

Eflornithine for treatment of high-risk neuroblastoma.
Jiang J, Yu Y
Trends Pharmacol Sci 2024 Jun;45(6):577-578. Epub 2024 May 14 doi: 10.1016/j.tips.2024.04.005. PMID: 38749882Free PMC Article
Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer.
Mosquera JM, Beltran H, Park K, MacDonald TY, Robinson BD, Tagawa ST, Perner S, Bismar TA, Erbersdobler A, Dhir R, Nelson JB, Nanus DM, Rubin MA
Neoplasia 2013 Jan;15(1):1-10. doi: 10.1593/neo.121550. PMID: 23358695Free PMC Article
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467

Recent clinical studies

Etiology

Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT
J Natl Cancer Inst 1997 Mar 5;89(5):373-80. doi: 10.1093/jnci/89.5.373. PMID: 9060959

Diagnosis

Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT
J Natl Cancer Inst 1997 Mar 5;89(5):373-80. doi: 10.1093/jnci/89.5.373. PMID: 9060959

Therapy

Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT
J Natl Cancer Inst 1997 Mar 5;89(5):373-80. doi: 10.1093/jnci/89.5.373. PMID: 9060959

Prognosis

Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT
J Natl Cancer Inst 1997 Mar 5;89(5):373-80. doi: 10.1093/jnci/89.5.373. PMID: 9060959
trk and ret proto-oncogene expression in human neuroblastoma specimens: high frequency of trk expression in non-advanced stages.
Borrello MG, Bongarzone I, Pierotti MA, Luksch R, Gasparini M, Collini P, Pilotti S, Rizzetti MG, Mondellini P, De Bernardi B
Int J Cancer 1993 Jun 19;54(4):540-5. doi: 10.1002/ijc.2910540404. PMID: 8514446

Clinical prediction guides

Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, Smith EI, Yu A, Brodeur GM, Hayes FA, Look AT
J Natl Cancer Inst 1997 Mar 5;89(5):373-80. doi: 10.1093/jnci/89.5.373. PMID: 9060959

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