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Smoldering plasma cell myeloma

MedGen UID:
280653
•Concept ID:
C1531608
•
Neoplastic Process
Synonyms: Asymptomatic Multiple Myeloma; Asymptomatic Multiple Myelomas; Multiple Myeloma, Asymptomatic; Multiple Myeloma, Smoldering; Multiple Myelomas, Asymptomatic; Myeloma, Smoldering; Smoldering Multiple Myeloma; Smoldering Multiple Myelomas; Smoldering Myeloma; Smoldering Myelomas
SNOMED CT: Smoldering multiple myeloma (413587002); Smoldering myeloma (413587002)
 
Monarch Initiative: MONDO:0005235

Definition

A plasma cell myeloma lacking clinical manifestations and organ impairment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmoldering plasma cell myeloma

Professional guidelines

PubMed

Assessing genome-wide copy number aberrations and copy-neutral loss-of-heterozygosity as best practice: An evidence-based review from the Cancer Genomics Consortium working group for plasma cell disorders.
Pugh TJ, Fink JM, Lu X, Mathew S, Murata-Collins J, Willem P, Fang M; Cancer Genomics Consortium Plasma Cell Disorders Working Group
Cancer Genet 2018 Dec;228-229:184-196. Epub 2018 Oct 5 doi: 10.1016/j.cancergen.2018.07.002. PMID: 30393007

Recent clinical studies

Etiology

Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations.
Milman T, Kao AA, Chu D, Gorski M, Steiner A, Simon CZ, Shih C, Aldave AJ, Eagle RC Jr, Jakobiec FA, Udell I
Ophthalmology 2015 Sep;122(9):1748-56. Epub 2015 Jun 26 doi: 10.1016/j.ophtha.2015.05.029. PMID: 26118999
Antigen Expression Patterns of Plasma Cell Myeloma: An Association of Cytogenetic Abnormality and International Staging System (ISS) for Myeloma.
Shin SY, Lee ST, Kim HJ, Kim SJ, Kim K, Kang ES, Kim SH
J Clin Lab Anal 2015 Nov;29(6):505-10. Epub 2014 Oct 2 doi: 10.1002/jcla.21801. PMID: 25277787Free PMC Article

Diagnosis

A case of AITL complicated by EBV-positive B cell and monoclonal plasma cell proliferation and effectively treated with lenalidomide.
Kishimoto W, Takiuchi Y, Nakae Y, Tabata S, Fukunaga A, Matsuzaki N, Yuba Y, Kitano T, Arima N
Int J Hematol 2019 Apr;109(4):499-504. Epub 2019 Jan 2 doi: 10.1007/s12185-018-02587-6. PMID: 30604313
Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations.
Milman T, Kao AA, Chu D, Gorski M, Steiner A, Simon CZ, Shih C, Aldave AJ, Eagle RC Jr, Jakobiec FA, Udell I
Ophthalmology 2015 Sep;122(9):1748-56. Epub 2015 Jun 26 doi: 10.1016/j.ophtha.2015.05.029. PMID: 26118999
Antigen Expression Patterns of Plasma Cell Myeloma: An Association of Cytogenetic Abnormality and International Staging System (ISS) for Myeloma.
Shin SY, Lee ST, Kim HJ, Kim SJ, Kim K, Kang ES, Kim SH
J Clin Lab Anal 2015 Nov;29(6):505-10. Epub 2014 Oct 2 doi: 10.1002/jcla.21801. PMID: 25277787Free PMC Article

Therapy

A case of AITL complicated by EBV-positive B cell and monoclonal plasma cell proliferation and effectively treated with lenalidomide.
Kishimoto W, Takiuchi Y, Nakae Y, Tabata S, Fukunaga A, Matsuzaki N, Yuba Y, Kitano T, Arima N
Int J Hematol 2019 Apr;109(4):499-504. Epub 2019 Jan 2 doi: 10.1007/s12185-018-02587-6. PMID: 30604313
Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations.
Milman T, Kao AA, Chu D, Gorski M, Steiner A, Simon CZ, Shih C, Aldave AJ, Eagle RC Jr, Jakobiec FA, Udell I
Ophthalmology 2015 Sep;122(9):1748-56. Epub 2015 Jun 26 doi: 10.1016/j.ophtha.2015.05.029. PMID: 26118999

Prognosis

A case of AITL complicated by EBV-positive B cell and monoclonal plasma cell proliferation and effectively treated with lenalidomide.
Kishimoto W, Takiuchi Y, Nakae Y, Tabata S, Fukunaga A, Matsuzaki N, Yuba Y, Kitano T, Arima N
Int J Hematol 2019 Apr;109(4):499-504. Epub 2019 Jan 2 doi: 10.1007/s12185-018-02587-6. PMID: 30604313
Antigen Expression Patterns of Plasma Cell Myeloma: An Association of Cytogenetic Abnormality and International Staging System (ISS) for Myeloma.
Shin SY, Lee ST, Kim HJ, Kim SJ, Kim K, Kang ES, Kim SH
J Clin Lab Anal 2015 Nov;29(6):505-10. Epub 2014 Oct 2 doi: 10.1002/jcla.21801. PMID: 25277787Free PMC Article

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