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Ancient Schwannoma

MedGen UID:
280690
•Concept ID:
C1536561
•
Neoplastic Process
Synonyms: Ancient neurilemmoma; Ancient Neurilemmoma; Ancient neurilemoma; Ancient schwannoma; Degenerated Neurilemmoma; Degenerated Schwannoma
SNOMED CT: Ancient neurilemmoma (404023006); Ancient schwannoma (409704009); Ancient neurilemoma (409704009); Ancient schwannoma (404023006)

Definition

A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAncient Schwannoma

Professional guidelines

PubMed

Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation.
Plotkin SR, Messiaen L, Legius E, Pancza P, Avery RA, Blakeley JO, Babovic-Vuksanovic D, Ferner R, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Hanemann CO, Kalamarides M, Kehrer-Sawatzki H, Korf BR, Mautner VF, MacCollin M, Papi L, Rauen KA, Riccardi V, Schorry E, Smith MJ, Stemmer-Rachamimov A, Stevenson DA, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC), Huson SM, Wolkenstein P, Evans DG
Genet Med 2022 Sep;24(9):1967-1977. Epub 2022 Jun 9 doi: 10.1016/j.gim.2022.05.007. PMID: 35674741
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
The Diagnosis and Management of Neurofibromatosis Type 1.
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003

Recent clinical studies

Etiology

Intramuscular peripheral nerve sheath tumors: schwannoma, ancient schwannoma, and neurofibroma.
Lee SK, Kim JY, Lee YS, Jeong HS
Skeletal Radiol 2020 Jun;49(6):967-975. Epub 2020 Jan 13 doi: 10.1007/s00256-020-03371-6. PMID: 31932870
Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience.
Ghosh A, Talwar OP, Pradhan SV
Kathmandu Univ Med J (KUMJ) 2010 Jan-Mar;8(29):97-101. doi: 10.3126/kumj.v8i1.3231. PMID: 21209517
Ancient schwannoma of the female pelvis.
Takeuchi M, Matsuzaki K, Nishitani H, Uehara H
Abdom Imaging 2008 Mar-Apr;33(2):247-52. doi: 10.1007/s00261-007-9228-y. PMID: 17440769
Plexiform pigmented schwannoma of the uvea.
Saavedra E, Singh AD, Sears JE, Ratliff NB
Surv Ophthalmol 2006 Mar-Apr;51(2):162-8. doi: 10.1016/j.survophthal.2005.12.004. PMID: 16500216
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Diagnosis

Endoscopic Management of Maxillary Sinus Schwannoma.
Celik T, Koca CF, Aydin S
J Craniofac Surg 2022 Jul-Aug 01;33(5):e505-e507. Epub 2022 Feb 2 doi: 10.1097/SCS.0000000000008481. PMID: 36041130
Intramuscular peripheral nerve sheath tumors: schwannoma, ancient schwannoma, and neurofibroma.
Lee SK, Kim JY, Lee YS, Jeong HS
Skeletal Radiol 2020 Jun;49(6):967-975. Epub 2020 Jan 13 doi: 10.1007/s00256-020-03371-6. PMID: 31932870
"Ancient" schwannoma of the submandibular gland: A case report and literature review.
Ho CF, Wu PW, Lee TJ, Huang CC
Medicine (Baltimore) 2017 Dec;96(51):e9134. doi: 10.1097/MD.0000000000009134. PMID: 29390442Free PMC Article
Ancient schwannoma.
Canella C, Costa F, Klumb E, Aymoré IL, Marchiori E
Arthritis Rheum 2013 Aug;65(8):2036. doi: 10.1002/art.37983. PMID: 23653321
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Therapy

When biopsy goes wrong: a case series of misdiagnoses and complications from biopsies of masses of unknown origin potentially originating from a peripheral nerve.
Guedes F, Henriques VM, Torrão FL, Haikal NP, Sanches GE, Barbosa DAN, Marsicano FG, Rosa LAN, Siquara AC, Malessy MJA
J Neurosurg 2024 Feb 1;140(2):480-488. Epub 2023 Aug 18 doi: 10.3171/2023.5.JNS23385. PMID: 37877976
Hyperferritinemia in a woman with systemic lupus erythematosus, severe nephritis and an iron-rich intraspinal schwannoma mimicking lupus myelopathy.
Conca W, Al-Hakim M, Moussa N, Al-Salam S, Corr P
Clin Exp Rheumatol 2009 Sep-Oct;27(5):834-7. PMID: 19917169
Ancient schwannoma of the female pelvis.
Takeuchi M, Matsuzaki K, Nishitani H, Uehara H
Abdom Imaging 2008 Mar-Apr;33(2):247-52. doi: 10.1007/s00261-007-9228-y. PMID: 17440769

Prognosis

Ancient Schwannoma: Case Report of an Unusual Entity in an Unusual Oral Location.
Alotaiby F
Am J Case Rep 2022 Dec 23;23:e938335. doi: 10.12659/AJCR.938335. PMID: 36560857Free PMC Article
Intramuscular ancient schwannoma of the axillary nerve.
Moond V, Diwaker P, Golamari R, Jain R
BMJ Case Rep 2021 May 24;14(5) doi: 10.1136/bcr-2020-239445. PMID: 34031064Free PMC Article
Abdominal Wall Schwannoma.
Ginesu GC, Puledda M, Feo CF, Cossu ML, Fancellu A, Addis F, Porcu A
J Gastrointest Surg 2016 Oct;20(10):1781-3. Epub 2016 May 16 doi: 10.1007/s11605-016-3164-5. PMID: 27184673
Retroperitoneal ancient schwannoma - case presentation.
Meşină C, Mogoantă SŞ, Cristian DA, Dumitrescu TV, Drăgoescu PO, Meşină-Botoran MI, Ciurea ME, Ghiluşi MC, Ciobanu D
Rom J Morphol Embryol 2015;56(4):1517-22. PMID: 26743303
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations.
Triantafyllou A
Pathol Res Pract 2021 Aug;224:153482. Epub 2021 May 13 doi: 10.1016/j.prp.2021.153482. PMID: 34153653
Endoscopic Transoral Resection of Tongue Base Ancient Schwannoma.
Yaslikaya S, Kizilay A, Şamdanci E
J Craniofac Surg 2020 Jun;31(4):e409-e411. doi: 10.1097/SCS.0000000000006416. PMID: 32195841
A Huge Ancient Schwannoma of the Epiglottis.
Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC
J Craniofac Surg 2016 Mar;27(2):e206-7. doi: 10.1097/SCS.0000000000002465. PMID: 26890461
Retroperitoneal "ancient" Schwannoma - a rare case of rare location: case report and literature review.
Walczak DA, Jaguścik R, Olborski B, Fałek W, Trzeciak PW
Pol Przegl Chir 2012 Dec;84(12):646-50. doi: 10.2478/v10035-012-0106-0. PMID: 23399632
Case report--ancient schwannoma of the scrotum.
Chan PT, Tripathi S, Low SE, Robinson LQ
BMC Urol 2007 Jan 23;7:1. doi: 10.1186/1471-2490-7-1. PMID: 17244372Free PMC Article

Recent systematic reviews

Intra-cerebellar schwannoma with various degenerative changes: a case report and a systematic review.
Takeuchi Y, Arakawa Y, Yokoo H, Mikami Y, Terada Y, Yoshida K, Miyamoto S, Haga H
BMC Neurol 2022 Feb 24;22(1):66. doi: 10.1186/s12883-022-02596-3. PMID: 35209854Free PMC Article
Ancient schwannoma mimicking a carotid body tumor A case report and review of the literature.
Garbuglio R, Turchino D, Giribono AM, Viviani E, Ferrante L, Sodo M, Del Guercio L, Bracale UM
Ann Ital Chir 2020 Jan 20;9 PMID: 31957705

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