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Hypereosinophilic syndrome

MedGen UID:
280990
•Concept ID:
C1540912
•
Disease or Syndrome
Synonyms: Hypereosinophilic Syndrome; Hypereosinophilic Syndromes; Syndrome, Hypereosinophilic; Syndromes, Hypereosinophilic
SNOMED CT: Hypereosinophilic syndrome (393573009); HES - hypereosinophilic syndrome (393573009); Hypereosinophilic syndrome (1156250009)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Unknown inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015691
Orphanet: ORPHA168956

Definition

Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage. [from ORDO]

Professional guidelines

PubMed

Diagnosis and Management of Pediatric Hypereosinophilic Syndrome.
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.
Klion A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):326-331. doi: 10.1182/asheducation-2018.1.326. PMID: 30504328Free PMC Article

Recent clinical studies

Etiology

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Diagnosis and Management of Pediatric Hypereosinophilic Syndrome.
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.
Klion A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):326-331. doi: 10.1182/asheducation-2018.1.326. PMID: 30504328Free PMC Article
Eosinophilia.
Kovalszki A, Weller PF
Prim Care 2016 Dec;43(4):607-617. Epub 2016 Oct 14 doi: 10.1016/j.pop.2016.07.010. PMID: 27866580Free PMC Article
Hypereosinophilic Syndrome.
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Diagnosis

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Diagnosis and Management of Pediatric Hypereosinophilic Syndrome.
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.
Klion A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):326-331. doi: 10.1182/asheducation-2018.1.326. PMID: 30504328Free PMC Article
Hypereosinophilic syndrome.
Noh HR, Magpantay GG
Allergy Asthma Proc 2017 Jan 1;38(1):78-81. doi: 10.2500/aap.2017.38.3995. PMID: 28052805
Hypereosinophilic Syndrome.
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Therapy

Approach to the patient with suspected hypereosinophilic syndrome.
Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial.
Roufosse F, Kahn JE, Rothenberg ME, Wardlaw AJ, Klion AD, Kirby SY, Gilson MJ, Bentley JH, Bradford ES, Yancey SW, Steinfeld J, Gleich GJ; HES Mepolizumab study group
J Allergy Clin Immunol 2020 Dec;146(6):1397-1405. Epub 2020 Sep 18 doi: 10.1016/j.jaci.2020.08.037. PMID: 32956756Free PMC Article
Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.
Klion A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):326-331. doi: 10.1182/asheducation-2018.1.326. PMID: 30504328Free PMC Article
How I treat hypereosinophilic syndromes.
Klion AD
Blood 2015 Aug 27;126(9):1069-77. Epub 2015 May 11 doi: 10.1182/blood-2014-11-551614. PMID: 25964669Free PMC Article

Prognosis

Approach to the patient with suspected hypereosinophilic syndrome.
Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Diagnosis and Management of Pediatric Hypereosinophilic Syndrome.
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Hypereosinophilic syndrome.
Noh HR, Magpantay GG
Allergy Asthma Proc 2017 Jan 1;38(1):78-81. doi: 10.2500/aap.2017.38.3995. PMID: 28052805
Hypereosinophilic Syndrome.
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Clinical prediction guides

Living without eosinophils: evidence from mouse and man.
Jackson DJ, Pavord ID
Eur Respir J 2023 Jan;61(1) Epub 2023 Jan 12 doi: 10.1183/13993003.01217-2022. PMID: 35953100Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases.
Pavord ID, Bel EH, Bourdin A, Chan R, Han JK, Keene ON, Liu MC, Martin N, Papi A, Roufosse F, Steinfeld J, Wechsler ME, Yancey SW
Allergy 2022 Mar;77(3):778-797. Epub 2021 Sep 16 doi: 10.1111/all.15056. PMID: 34402066Free PMC Article
Myeloid neoplasms with eosinophilia.
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Significance of elevated cobalamin (vitamin B12) levels in blood.
Ermens AA, Vlasveld LT, Lindemans J
Clin Biochem 2003 Nov;36(8):585-90. doi: 10.1016/j.clinbiochem.2003.08.004. PMID: 14636871

Recent systematic reviews

Imaging patterns of cerebral ischemia in hypereosinophilic syndrome: case report and systematic review.
Miethe K, Iordanishvili E, Habib P, Panse J, Krämer S, Wiesmann M, Schulz JB, Nikoubashman O, Reich A, Pinho J
Neurol Sci 2022 Aug;43(8):5091-5094. Epub 2022 May 19 doi: 10.1007/s10072-022-06134-4. PMID: 35590001Free PMC Article
What we have learned about lymphocytic variant hypereosinophilic syndrome: A systematic literature review.
Shi Y, Wang C
Clin Immunol 2022 Apr;237:108982. Epub 2022 Mar 17 doi: 10.1016/j.clim.2022.108982. PMID: 35307610
Mepolizumab in Hypereosinophilic Syndrome: A Systematic Review and Meta-analysis.
Alves Júnior JM, Prota FE, Villagelin D, Bley F, Bernardo WM
Clinics (Sao Paulo) 2021;76:e3271. Epub 2021 Oct 11 doi: 10.6061/clinics/2021/e3271. PMID: 34644737Free PMC Article
Endomyocardiofibrosis: A Systematic Review.
Scatularo CE, Posada Martínez EL, Saldarriaga C, Ballesteros OA, Baranchuk A, Sosa Liprandi A, Wyss F, Sosa Liprandi MI
Curr Probl Cardiol 2021 Apr;46(4):100784. Epub 2020 Dec 26 doi: 10.1016/j.cpcardiol.2020.100784. PMID: 33418479
Gleich syndrome: a systematic review.
Haber R, Chebl JA, El Gemayel M, Salloum A
Int J Dermatol 2020 Dec;59(12):1458-1465. Epub 2020 Jun 18 doi: 10.1111/ijd.14963. PMID: 32557651

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