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Hypereosinophilic syndrome

MedGen UID:
280990
Concept ID:
C1540912
Disease or Syndrome
Synonyms: Hypereosinophilic Syndrome; Hypereosinophilic Syndromes; Syndrome, Hypereosinophilic; Syndromes, Hypereosinophilic
SNOMED CT: Hypereosinophilic syndrome (393573009); HES - hypereosinophilic syndrome (393573009); Hypereosinophilic syndrome (1156250009)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015691
Orphanet: ORPHA168956

Definition

Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypereosinophilic syndrome
Follow this link to review classifications for Hypereosinophilic syndrome in Orphanet.

Professional guidelines

PubMed

Valent P, Klion AD, Roufosse F, Simon D, Metzgeroth G, Leiferman KM, Schwaab J, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Hoermann G, Haferlach T, Moriggl R, George TI, Akin C, Bochner BS, Gotlib J, Reiter A, Horny HP, Arock M, Simon HU, Gleich GJ
Allergy 2023 Jan;78(1):47-59. Epub 2022 Oct 19 doi: 10.1111/all.15544. PMID: 36207764Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850

Recent clinical studies

Etiology

Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Kovalszki A, Weller PF
Prim Care 2016 Dec;43(4):607-617. Epub 2016 Oct 14 doi: 10.1016/j.pop.2016.07.010. PMID: 27866580Free PMC Article
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Diagnosis

Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Wang SA
Pathobiology 2019;86(1):39-52. Epub 2018 Jun 29 doi: 10.1159/000489341. PMID: 29961056
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Therapy

Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Roufosse F, Kahn JE, Rothenberg ME, Wardlaw AJ, Klion AD, Kirby SY, Gilson MJ, Bentley JH, Bradford ES, Yancey SW, Steinfeld J, Gleich GJ; HES Mepolizumab study group
J Allergy Clin Immunol 2020 Dec;146(6):1397-1405. Epub 2020 Sep 18 doi: 10.1016/j.jaci.2020.08.037. PMID: 32956756Free PMC Article
Klion A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):326-331. doi: 10.1182/asheducation-2018.1.326. PMID: 30504328Free PMC Article
Ogbogu PU, Klion AD
J Allergy Clin Immunol Pract 2015 Mar-Apr;3(2):304-5; quiz 306. doi: 10.1016/j.jaip.2014.09.024. PMID: 25754721Free PMC Article

Prognosis

Wechsler ME, Hellmich B, Cid MC, Jayne D, Tian X, Baylis L, Roufosse F
J Allergy Clin Immunol 2023 Jun;151(6):1415-1428. Epub 2023 Apr 21 doi: 10.1016/j.jaci.2023.03.011. PMID: 37086239
Klion AD
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):47-54. doi: 10.1182/hematology.2022000367. PMID: 36485140Free PMC Article
Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Curtis C, Ogbogu P
Clin Rev Allergy Immunol 2016 Apr;50(2):240-51. doi: 10.1007/s12016-015-8506-7. PMID: 26475367

Clinical prediction guides

Wechsler ME, Hellmich B, Cid MC, Jayne D, Tian X, Baylis L, Roufosse F
J Allergy Clin Immunol 2023 Jun;151(6):1415-1428. Epub 2023 Apr 21 doi: 10.1016/j.jaci.2023.03.011. PMID: 37086239
Jackson DJ, Pavord ID
Eur Respir J 2023 Jan;61(1) Epub 2023 Jan 12 doi: 10.1183/13993003.01217-2022. PMID: 35953100Free PMC Article
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Pavord ID, Bel EH, Bourdin A, Chan R, Han JK, Keene ON, Liu MC, Martin N, Papi A, Roufosse F, Steinfeld J, Wechsler ME, Yancey SW
Allergy 2022 Mar;77(3):778-797. Epub 2021 Sep 16 doi: 10.1111/all.15056. PMID: 34402066Free PMC Article
Ermens AA, Vlasveld LT, Lindemans J
Clin Biochem 2003 Nov;36(8):585-90. doi: 10.1016/j.clinbiochem.2003.08.004. PMID: 14636871

Recent systematic reviews

Techasatian W, Gozun M, Vo K, Yokoyama J, Nagamine T, Shah P, Vu K, Zhang J, Nishimura Y
Heart 2024 Apr 25;110(10):687-693. doi: 10.1136/heartjnl-2023-323225. PMID: 37963727
Shi Y, Wang C
Clin Immunol 2022 Apr;237:108982. Epub 2022 Mar 17 doi: 10.1016/j.clim.2022.108982. PMID: 35307610
Alves Júnior JM, Prota FE, Villagelin D, Bley F, Bernardo WM
Clinics (Sao Paulo) 2021;76:e3271. Epub 2021 Oct 11 doi: 10.6061/clinics/2021/e3271. PMID: 34644737Free PMC Article
Scatularo CE, Posada Martínez EL, Saldarriaga C, Ballesteros OA, Baranchuk A, Sosa Liprandi A, Wyss F, Sosa Liprandi MI
Curr Probl Cardiol 2021 Apr;46(4):100784. Epub 2020 Dec 26 doi: 10.1016/j.cpcardiol.2020.100784. PMID: 33418479
Haber R, Chebl JA, El Gemayel M, Salloum A
Int J Dermatol 2020 Dec;59(12):1458-1465. Epub 2020 Jun 18 doi: 10.1111/ijd.14963. PMID: 32557651

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