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Capgras syndrome

MedGen UID:
2811
Concept ID:
C0006895
Mental or Behavioral Dysfunction
Synonyms: Capgras Syndrome; Syndrome, Capgras
SNOMED CT: Delusional misidentification syndrome (44906001); Capgras syndrome (44906001); Capgras' syndrome (44906001)
 
Monarch Initiative: MONDO:0003965

Definition

A rare neuropsychiatric disorder whose primary feature is the delusion that relatives or close acquaintances are not the persons that they are known to be. Visual recognition appears intact but familiar persons are thought be imposters, that is, they appear similar or identical to known individuals but are not. Most cases are seen in the context of a psychotic state. However, if manifested post-traumatically, the cause is most likely due to neurologic impairment. This disorder should be contrasted with prosopagnosia, in which an individual may not recognize a familiar person at all. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCapgras syndrome

Professional guidelines

PubMed

Rapinesi C, Kotzalidis GD, Del Casale A, Ferri VR, Di Pietro S, Scatena P, Serata D, Danese E, Sani G, Koukopoulos AE, Angeletti G, Girardi P
Int J Psychiatry Med 2015;49(3):227-34. Epub 2015 Apr 29 doi: 10.1177/0091217415582193. PMID: 25926594
Christodoulou GN
Acta Psychiatr Belg 1977 Mar-Apr;77(2):254-9. PMID: 20738

Recent clinical studies

Etiology

Karakasi MV, Markopoulou M, Alexandri M, Douzenis A, Pavlidis P
J Forensic Leg Med 2019 Aug;66:8-24. Epub 2019 May 31 doi: 10.1016/j.jflm.2019.05.019. PMID: 31176280
Ardila A
Appl Neuropsychol Adult 2019 Nov-Dec;26(6):591-597. Epub 2018 Sep 5 doi: 10.1080/23279095.2018.1463224. PMID: 30183352
Barrelle A, Luauté JP
Front Neurol Neurosci 2018;42:35-43. Epub 2017 Nov 17 doi: 10.1159/000475680. PMID: 29151089
Josephs KA
Arch Neurol 2007 Dec;64(12):1762-6. doi: 10.1001/archneur.64.12.1762. PMID: 18071040
Agnihotri SS
J Assoc Physicians India 1982 Jun;30(6):393-4. PMID: 7169460

Diagnosis

Ventriglio A, Bhugra D, De Berardis D, Torales J, Castaldelli-Maia JM, Fiorillo A
Int Rev Psychiatry 2020 Aug-Sep;32(5-6):391-395. Epub 2020 May 7 doi: 10.1080/09540261.2020.1756625. PMID: 32378427
Barrelle A, Luauté JP
Front Neurol Neurosci 2018;42:35-43. Epub 2017 Nov 17 doi: 10.1159/000475680. PMID: 29151089
Feinberg TE, Roane DM
Psychiatr Clin North Am 2005 Sep;28(3):665-83, 678-9. doi: 10.1016/j.psc.2005.05.002. PMID: 16122573
Mojtabai R
Aust N Z J Psychiatry 1994 Sep;28(3):458-62. doi: 10.3109/00048679409075874. PMID: 7893241
Berson RJ
Am J Psychiatry 1983 Aug;140(8):969-78. doi: 10.1176/ajp.140.8.969. PMID: 6869616

Therapy

Baykal S, Mutlu C
Clin Neuropharmacol 2023 Mar-Apr 01;46(2):85-86. Epub 2022 Dec 27 doi: 10.1097/WNF.0000000000000536. PMID: 36728844
Karakasi MV, Markopoulou M, Alexandri M, Douzenis A, Pavlidis P
J Forensic Leg Med 2019 Aug;66:8-24. Epub 2019 May 31 doi: 10.1016/j.jflm.2019.05.019. PMID: 31176280
Cannas A, Meloni M, Mascia MM, Solla P, Cocco L, Muroni A, Floris G, Di Stefano F, Marrosu F
Neurol Sci 2017 Feb;38(2):225-231. Epub 2016 Nov 15 doi: 10.1007/s10072-016-2765-9. PMID: 27848117
Thaipisuttikul P, Lobach I, Zweig Y, Gurnani A, Galvin JE
Int Psychogeriatr 2013 May;25(5):843-9. Epub 2012 Dec 5 doi: 10.1017/S1041610212002189. PMID: 23211760Free PMC Article
Agnihotri SS
J Assoc Physicians India 1982 Jun;30(6):393-4. PMID: 7169460

Prognosis

Christodoulou GN, Margariti M, Christodoulou N
Psychiatriki 2018 Jan-Mar;29(1):15-18. doi: 10.22365/jpsych.2018.291.15. PMID: 29754115
Mojtabai R
Aust N Z J Psychiatry 1994 Sep;28(3):458-62. doi: 10.3109/00048679409075874. PMID: 7893241
Ellis HD, Young AW
Br J Psychiatry 1990 Aug;157:239-48. doi: 10.1192/bjp.157.2.239. PMID: 2224375
Agnihotri SS
J Assoc Physicians India 1982 Jun;30(6):393-4. PMID: 7169460
Christodoulou GN
J Nerv Ment Dis 1978 Jan;166(1):68-72. PMID: 619004

Clinical prediction guides

Ventriglio A, Bhugra D, De Berardis D, Torales J, Castaldelli-Maia JM, Fiorillo A
Int Rev Psychiatry 2020 Aug-Sep;32(5-6):391-395. Epub 2020 May 7 doi: 10.1080/09540261.2020.1756625. PMID: 32378427
Ardila A
Appl Neuropsychol Adult 2019 Nov-Dec;26(6):591-597. Epub 2018 Sep 5 doi: 10.1080/23279095.2018.1463224. PMID: 30183352
Barrelle A, Luauté JP
Front Neurol Neurosci 2018;42:35-43. Epub 2017 Nov 17 doi: 10.1159/000475680. PMID: 29151089
Cannas A, Meloni M, Mascia MM, Solla P, Cocco L, Muroni A, Floris G, Di Stefano F, Marrosu F
Neurol Sci 2017 Feb;38(2):225-231. Epub 2016 Nov 15 doi: 10.1007/s10072-016-2765-9. PMID: 27848117
Bourget D, Whitehurst L
Can J Psychiatry 2004 Nov;49(11):719-25. doi: 10.1177/070674370404901102. PMID: 15633849

Recent systematic reviews

Lewis G, Blake L, Seneviratne G
Psychopathology 2023;56(4):285-294. Epub 2022 Sep 16 doi: 10.1159/000526129. PMID: 36116435
Pandis C, Agrawal N, Poole N
Psychopathology 2019;52(3):161-173. Epub 2019 Jul 19 doi: 10.1159/000500474. PMID: 31326968

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