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Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

MedGen UID:
281330
•Concept ID:
C1556385
•
Finding
Synonym: CTCAE Grade 4 Pharynx mucositis/stomatitis (clinical exam)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

Professional guidelines

PubMed

Pain management in patients undergoing radiation therapy for head and neck cancer - a descriptive study.
Schaller AKCS, Peterson A, Bäckryd E
Scand J Pain 2021 Apr 27;21(2):256-265. Epub 2020 Dec 10 doi: 10.1515/sjpain-2020-0067. PMID: 34387952
IMRT with the use of simultaneous integrated boost in treatment of head and neck cancer: acute toxicity evaluation.
Vosmik M, Odrázka K, Dolezel M, Vaculíková M, Kordac P, Zouhar M, Petera J, Jansa J, Zoul Z, Paluska P, Vokurka J
Acta Medica (Hradec Kralove) 2006;49(3):167-73. PMID: 17117605
Management of injuries from liquid lye ingestion.
Meredith JW, Kon ND, Thompson JN
J Trauma 1988 Aug;28(8):1173-80. doi: 10.1097/00005373-198808000-00007. PMID: 3411641

Recent clinical studies

Etiology

Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma.
Ogasawara N, Kikuchi D, Tanaka M, Ochiai Y, Okamura T, Hayasaka J, Suzuki Y, Mitsunaga Y, Nomura K, Odagiri H, Yamashita S, Matsui A, Hoteya S
Esophagus 2022 Jul;19(3):460-468. Epub 2022 Jan 31 doi: 10.1007/s10388-022-00907-8. PMID: 35099639
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.
Nasuf AWA, Ojha S, Dorling J
Cochrane Database Syst Rev 2018 Sep 7;9(9):CD011921. doi: 10.1002/14651858.CD011921.pub2. PMID: 30191961Free PMC Article
Validation of the secretion severity rating scale.
Pluschinski P, Zaretsky E, Stöver T, Murray J, Sader R, Hey C
Eur Arch Otorhinolaryngol 2016 Oct;273(10):3215-8. Epub 2016 May 12 doi: 10.1007/s00405-016-4073-7. PMID: 27173156
Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection.
Kuwabara T, Hiyama T, Oka S, Urabe Y, Tanaka S, Yoshihara M, Arihiro K, Shimamoto F, Chayama K
Gastrointest Endosc 2012 Dec;76(6):1095-103. Epub 2012 Sep 27 doi: 10.1016/j.gie.2012.07.032. PMID: 23022050
Dysphagia following chemoradiation for locally advanced head and neck cancer.
Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S
Ann Oncol 2004 Mar;15(3):383-8. doi: 10.1093/annonc/mdh101. PMID: 14998839

Diagnosis

Phonotherapeutic Intervention in Patients With Mucosal Leishmaniasis Sequelae.
Machado de Machado FC, Lessa MM, Cielo CA, Souza TMO, Prates de Souza FV, Ribeiro CS, Silva JA, Filho EMC, Machado PRL, Montagner T, Muniz MM, Barbosa TN, Gonçalves DDS, Cincurá C
J Voice 2020 Sep;34(5):720-731. Epub 2019 Feb 20 doi: 10.1016/j.jvoice.2018.12.015. PMID: 30795925
Definitive Intensity-modulated Radiation Therapy in Elderly Patients with Locally Advanced Oropharyngeal Cancer.
DE Felice F, Galdieri A, Abate G, Bulzonetti N, Musio D, Tombolini V
In Vivo 2017 May-Jun;31(3):455-459. doi: 10.21873/invivo.11083. PMID: 28438879Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206
Validation of the secretion severity rating scale.
Pluschinski P, Zaretsky E, Stöver T, Murray J, Sader R, Hey C
Eur Arch Otorhinolaryngol 2016 Oct;273(10):3215-8. Epub 2016 May 12 doi: 10.1007/s00405-016-4073-7. PMID: 27173156
NUTRITIONAL, MICROBIOLOGICAL, AND THERAPEUTIC FACTORS RELATED TO MUCOSITIS IN HEAD AND NECK CANCER PATIENTS: A COHORT STUDY.
Vidal-Casariego A, Fernández-Natal I, Calleja-Fernández A, Parras-Padilla T, Cano-Rodríguez I, Prieto-Alonso B, Ballesteros-Pomar MD
Nutr Hosp 2015 Sep 1;32(3):1208-13. doi: 10.3305/nh.2015.32.3.9299. PMID: 26319840

Therapy

Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma.
Ogasawara N, Kikuchi D, Tanaka M, Ochiai Y, Okamura T, Hayasaka J, Suzuki Y, Mitsunaga Y, Nomura K, Odagiri H, Yamashita S, Matsui A, Hoteya S
Esophagus 2022 Jul;19(3):460-468. Epub 2022 Jan 31 doi: 10.1007/s10388-022-00907-8. PMID: 35099639
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.
Nasuf AWA, Ojha S, Dorling J
Cochrane Database Syst Rev 2018 Sep 7;9(9):CD011921. doi: 10.1002/14651858.CD011921.pub2. PMID: 30191961Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206
Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study.
Gouvêa de Lima A, Villar RC, de Castro G Jr, Antequera R, Gil E, Rosalmeida MC, Federico MH, Snitcovsky IM
Int J Radiat Oncol Biol Phys 2012 Jan 1;82(1):270-5. Epub 2010 Dec 14 doi: 10.1016/j.ijrobp.2010.10.012. PMID: 21163585
Dysphagia following chemoradiation for locally advanced head and neck cancer.
Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S
Ann Oncol 2004 Mar;15(3):383-8. doi: 10.1093/annonc/mdh101. PMID: 14998839

Prognosis

Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma.
Ogasawara N, Kikuchi D, Tanaka M, Ochiai Y, Okamura T, Hayasaka J, Suzuki Y, Mitsunaga Y, Nomura K, Odagiri H, Yamashita S, Matsui A, Hoteya S
Esophagus 2022 Jul;19(3):460-468. Epub 2022 Jan 31 doi: 10.1007/s10388-022-00907-8. PMID: 35099639
Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.
Nasuf AWA, Ojha S, Dorling J
Cochrane Database Syst Rev 2018 Sep 7;9(9):CD011921. doi: 10.1002/14651858.CD011921.pub2. PMID: 30191961Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206
Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection.
Kuwabara T, Hiyama T, Oka S, Urabe Y, Tanaka S, Yoshihara M, Arihiro K, Shimamoto F, Chayama K
Gastrointest Endosc 2012 Dec;76(6):1095-103. Epub 2012 Sep 27 doi: 10.1016/j.gie.2012.07.032. PMID: 23022050
Dysphagia following chemoradiation for locally advanced head and neck cancer.
Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S
Ann Oncol 2004 Mar;15(3):383-8. doi: 10.1093/annonc/mdh101. PMID: 14998839

Clinical prediction guides

Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma.
Ogasawara N, Kikuchi D, Tanaka M, Ochiai Y, Okamura T, Hayasaka J, Suzuki Y, Mitsunaga Y, Nomura K, Odagiri H, Yamashita S, Matsui A, Hoteya S
Esophagus 2022 Jul;19(3):460-468. Epub 2022 Jan 31 doi: 10.1007/s10388-022-00907-8. PMID: 35099639
Definitive Intensity-modulated Radiation Therapy in Elderly Patients with Locally Advanced Oropharyngeal Cancer.
DE Felice F, Galdieri A, Abate G, Bulzonetti N, Musio D, Tombolini V
In Vivo 2017 May-Jun;31(3):455-459. doi: 10.21873/invivo.11083. PMID: 28438879Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206
Validation of the secretion severity rating scale.
Pluschinski P, Zaretsky E, Stöver T, Murray J, Sader R, Hey C
Eur Arch Otorhinolaryngol 2016 Oct;273(10):3215-8. Epub 2016 May 12 doi: 10.1007/s00405-016-4073-7. PMID: 27173156
Dysphagia following chemoradiation for locally advanced head and neck cancer.
Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, Midyett FA, Barloon J, Sallah S
Ann Oncol 2004 Mar;15(3):383-8. doi: 10.1093/annonc/mdh101. PMID: 14998839

Recent systematic reviews

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.
Nasuf AWA, Ojha S, Dorling J
Cochrane Database Syst Rev 2018 Sep 7;9(9):CD011921. doi: 10.1002/14651858.CD011921.pub2. PMID: 30191961Free PMC Article

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