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Grade 5 Colitis, CTCAE

MedGen UID:
282060
•Concept ID:
C1559281
•
Finding

Definition

Death [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 5 Colitis, CTCAE

Professional guidelines

PubMed

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article

Recent clinical studies

Etiology

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab.
Alexander JL, Ibraheim H, Sheth B, Little J, Khan MS, Richards C, Hunter N, Chauhan D, Ratnakumaran R, McHugh K, Pinato DJ, Nathan P, Choy J, Crusz SM, Furness A, Turajlic S, Pickering L, Larkin J, Teare JP, Papa S, Speight A, Sharma A, Powell N
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002742. PMID: 34233964Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Diagnosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma.
Callaghan CM, Seyedin SN, Mohiuddin IH, Hawkes KL, Petronek MS, Anderson CM, Buatti JM, Milhem MM, Monga V, Allen BG
Radiat Res 2020 Aug 1;194(2):124-132. doi: 10.1667/RADE-20-00017. PMID: 32845986Free PMC Article
Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control.
Hughes MS, Zheng H, Zubiri L, Molina GE, Chen ST, Mooradian MJ, Allen IM, Reynolds KL, Dougan M
Cancer Med 2019 Sep;8(11):4986-4999. Epub 2019 Jul 9 doi: 10.1002/cam4.2397. PMID: 31286682Free PMC Article
Autoimmune Colitis and Subsequent CMV-induced Hepatitis After Treatment With Ipilimumab.
Uslu U, Agaimy A, Hundorfean G, Harrer T, Schuler G, Heinzerling L
J Immunother 2015 Jun;38(5):212-5. doi: 10.1097/CJI.0000000000000081. PMID: 25962110

Therapy

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis.
Holmstroem RB, Nielsen OH, Jacobsen S, Riis LB, Theile S, Bjerrum JT, Vilmann P, Johansen JS, Boisen MK, Eefsen RHL, Marie Svane I, Nielsen DL, Chen IM
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005111. PMID: 36096534Free PMC Article
Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article

Prognosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
Conditional immune toxicity rate in patients with metastatic renal and urothelial cancer treated with immune checkpoint inhibitors.
Nuzzo PV, Pond GR, Abou Alaiwi S, Nassar AH, Flippot R, Curran C, Kilbridge KL, Wei XX, McGregor BA, Choueiri T, Harshman LC, Sonpavde G
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2019-000371. PMID: 32234849Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Clinical prediction guides

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
SAKK 19/17: safety analysis of first-line durvalumab in patients with PD-L1 positive, advanced nonsmall cell lung cancer and a performance status of 2.
Mark M, Froesch P, Eboulet EI, Addeo A, Pless M, Rothschild SI, Janthur WD, Burmeister H, Friedlaender A, Schneider M, Metaxas Y, Joerger M, Wannesson L, Schwitter M, Baudoux N, Weindler S, Biaggi-Rudolf C, Früh M; Swiss Group for Clinical Cancer Research (SAKK)
Cancer Immunol Immunother 2021 May;70(5):1255-1262. Epub 2020 Nov 1 doi: 10.1007/s00262-020-02757-8. PMID: 33130956Free PMC Article
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma.
Callaghan CM, Seyedin SN, Mohiuddin IH, Hawkes KL, Petronek MS, Anderson CM, Buatti JM, Milhem MM, Monga V, Allen BG
Radiat Res 2020 Aug 1;194(2):124-132. doi: 10.1667/RADE-20-00017. PMID: 32845986Free PMC Article

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