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Grade 1 Constipation, CTCAE

MedGen UID:
282061
•Concept ID:
C1559282
•
Finding

Definition

Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Constipation, CTCAE

Recent clinical studies

Etiology

Prolonged usage of fosaprepitant for prevention of delayed chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly emetogenic chemotherapy.
Gao A, Guan S, Sun Y, Wang L, Meng F, Liu X, Gu L, Li G, Zhong D, Zhang L
BMC Cancer 2023 Jul 1;23(1):609. doi: 10.1186/s12885-023-11070-3. PMID: 37393241Free PMC Article
A Phase I Study of Gemcitabine/Nab-Paclitaxel/S-1 Chemotherapy in Patients With Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma.
Chang C, Li X, Cheng K, Cai Z, Xiong J, Lv W, Li R, Zhang P, Cao D
Oncologist 2023 Jul 5;28(7):e575-e584. doi: 10.1093/oncolo/oyac146. PMID: 35930304Free PMC Article
Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study.
Schenk H, Holle D, Nsaka M, Kleinschnitz C, Glas M, Scheffler A
J Headache Pain 2022 May 11;23(1):55. doi: 10.1186/s10194-022-01426-8. PMID: 35538414Free PMC Article
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for rare gynecologic indications: peritoneal metastases from breast and endometrial cancer.
Rezniczek GA, Giger-Pabst U, Thaher O, Tempfer CB
BMC Cancer 2020 Nov 19;20(1):1122. doi: 10.1186/s12885-020-07627-1. PMID: 33213407Free PMC Article
Evaluating iatrogenic prescribing: development of an oncology-focused trigger tool.
Hébert G, Netzer F, Ferrua M, Ducreux M, Lemare F, Minvielle E
Eur J Cancer 2015 Feb;51(3):427-35. Epub 2014 Dec 27 doi: 10.1016/j.ejca.2014.12.002. PMID: 25549531

Diagnosis

PSMA ADC monotherapy in patients with progressive metastatic castration-resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open-label single-arm phase 2 study.
Petrylak DP, Vogelzang NJ, Chatta K, Fleming MT, Smith DC, Appleman LJ, Hussain A, Modiano M, Singh P, Tagawa ST, Gore I, McClay EF, Mega AE, Sartor AO, Somer B, Wadlow R, Shore ND, Olson WC, Stambler N, DiPippo VA, Israel RJ
Prostate 2020 Jan;80(1):99-108. Epub 2019 Nov 19 doi: 10.1002/pros.23922. PMID: 31742767
Evaluating iatrogenic prescribing: development of an oncology-focused trigger tool.
Hébert G, Netzer F, Ferrua M, Ducreux M, Lemare F, Minvielle E
Eur J Cancer 2015 Feb;51(3):427-35. Epub 2014 Dec 27 doi: 10.1016/j.ejca.2014.12.002. PMID: 25549531
Evaluation of interobserver and interscale agreement in assessing late bowel toxicity after pelvic radiation in patients with carcinoma of the cervix.
Chinnachamy AN, Chopra S, Krishnatry R, Kannan S, Thomas B, Mahantshetty U, Engineer R, Shrivastava SK
Jpn J Clin Oncol 2013 May;43(5):508-14. Epub 2013 Mar 20 doi: 10.1093/jjco/hyt028. PMID: 23515269
Feasibility study of paclitaxel plus carboplatin in patients with endometrial cancer: a Japan Kanto Tumor Board study (JKTB trial).
Yamada K, Tanabe H, Imai M, Jobo T, Kudo K, Fujiwara H, Nagata C, Furuya K, Suzuki M, Ochiai K, Tanaka T, Yasuda M
J Obstet Gynaecol Res 2013 Jan;39(1):311-6. Epub 2012 May 28 doi: 10.1111/j.1447-0756.2012.01890.x. PMID: 22639962
Adverse symptom event reporting by patients vs clinicians: relationships with clinical outcomes.
Basch E, Jia X, Heller G, Barz A, Sit L, Fruscione M, Appawu M, Iasonos A, Atkinson T, Goldfarb S, Culkin A, Kris MG, Schrag D
J Natl Cancer Inst 2009 Dec 2;101(23):1624-32. Epub 2009 Nov 17 doi: 10.1093/jnci/djp386. PMID: 19920223Free PMC Article

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Prolonged usage of fosaprepitant for prevention of delayed chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly emetogenic chemotherapy.
Gao A, Guan S, Sun Y, Wang L, Meng F, Liu X, Gu L, Li G, Zhong D, Zhang L
BMC Cancer 2023 Jul 1;23(1):609. doi: 10.1186/s12885-023-11070-3. PMID: 37393241Free PMC Article
Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253
Self-evaluation of Adjuvant Chemotherapy-Related Adverse Effects by Patients With Breast Cancer.
Montemurro F, Mittica G, Cagnazzo C, Longo V, Berchialla P, Solinas G, Culotta P, Martinello R, Foresto M, Gallizioli S, Calori A, Grasso B, Volpone C, Bertola G, Parola G, Tealdi G, Giuliano PL, Aglietta M, Ballari AM
JAMA Oncol 2016 Apr;2(4):445-52. doi: 10.1001/jamaoncol.2015.4720. PMID: 26720497

Prognosis

Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study.
Schenk H, Holle D, Nsaka M, Kleinschnitz C, Glas M, Scheffler A
J Headache Pain 2022 May 11;23(1):55. doi: 10.1186/s10194-022-01426-8. PMID: 35538414Free PMC Article
Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
PSMA ADC monotherapy in patients with progressive metastatic castration-resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open-label single-arm phase 2 study.
Petrylak DP, Vogelzang NJ, Chatta K, Fleming MT, Smith DC, Appleman LJ, Hussain A, Modiano M, Singh P, Tagawa ST, Gore I, McClay EF, Mega AE, Sartor AO, Somer B, Wadlow R, Shore ND, Olson WC, Stambler N, DiPippo VA, Israel RJ
Prostate 2020 Jan;80(1):99-108. Epub 2019 Nov 19 doi: 10.1002/pros.23922. PMID: 31742767
Evaluating iatrogenic prescribing: development of an oncology-focused trigger tool.
Hébert G, Netzer F, Ferrua M, Ducreux M, Lemare F, Minvielle E
Eur J Cancer 2015 Feb;51(3):427-35. Epub 2014 Dec 27 doi: 10.1016/j.ejca.2014.12.002. PMID: 25549531
Adverse symptom event reporting by patients vs clinicians: relationships with clinical outcomes.
Basch E, Jia X, Heller G, Barz A, Sit L, Fruscione M, Appawu M, Iasonos A, Atkinson T, Goldfarb S, Culkin A, Kris MG, Schrag D
J Natl Cancer Inst 2009 Dec 2;101(23):1624-32. Epub 2009 Nov 17 doi: 10.1093/jnci/djp386. PMID: 19920223Free PMC Article

Clinical prediction guides

Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study.
Schenk H, Holle D, Nsaka M, Kleinschnitz C, Glas M, Scheffler A
J Headache Pain 2022 May 11;23(1):55. doi: 10.1186/s10194-022-01426-8. PMID: 35538414Free PMC Article
A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses.
Matei D, Ghamande S, Roman L, Alvarez Secord A, Nemunaitis J, Markham MJ, Nephew KP, Jueliger S, Oganesian A, Naim S, Su XY, Keer H, Azab M, Fleming GF
Clin Cancer Res 2018 May 15;24(10):2285-2293. Epub 2018 Mar 2 doi: 10.1158/1078-0432.CCR-17-3055. PMID: 29500276Free PMC Article
Pharmacovigilance in Hospice/Palliative Care: Net Effect of Haloperidol for Nausea or Vomiting.
Digges M, Hussein A, Wilcock A, Crawford GB, Boland JW, Agar MR, Sinnarajah A, Currow DC, Johnson MJ
J Palliat Med 2018 Jan;21(1):37-43. Epub 2017 Aug 3 doi: 10.1089/jpm.2017.0159. PMID: 28772094
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253
Evaluating iatrogenic prescribing: development of an oncology-focused trigger tool.
Hébert G, Netzer F, Ferrua M, Ducreux M, Lemare F, Minvielle E
Eur J Cancer 2015 Feb;51(3):427-35. Epub 2014 Dec 27 doi: 10.1016/j.ejca.2014.12.002. PMID: 25549531

Recent systematic reviews

Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

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