U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 4 Proctitis, CTCAE

MedGen UID:
282080
•Concept ID:
C1559354
•
Finding

Definition

Life-threatening consequences; urgent intervention indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Proctitis, CTCAE

Recent clinical studies

Etiology

Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Late toxicities of prostate cancer radiotherapy with and without hydrogel SpaceAOR insertion.
Te Velde BL, Westhuyzen J, Awad N, Wood M, Shakespeare TP
J Med Imaging Radiat Oncol 2019 Dec;63(6):836-841. Epub 2019 Sep 13 doi: 10.1111/1754-9485.12945. PMID: 31520465
Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy.
Saadipoor A, Razzaghdoust A, Simforoosh N, Mahdavi A, Bakhshandeh M, Moghadam M, Abdollahi H, Mofid B
Phytother Res 2019 Feb;33(2):370-378. Epub 2018 Nov 14 doi: 10.1002/ptr.6230. PMID: 30427093

Diagnosis

Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
Schirmer MA, Mergler CP, Rave-Fränk M, Herrmann MK, Hennies S, Gaedcke J, Conradi LC, Jo P, Beissbarth T, Hess CF, Becker H, Ghadimi M, Brockmöller J, Christiansen H, Wolff HA
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):149-57. Epub 2011 Oct 12 doi: 10.1016/j.ijrobp.2011.05.063. PMID: 22000747

Therapy

Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Late toxicities of prostate cancer radiotherapy with and without hydrogel SpaceAOR insertion.
Te Velde BL, Westhuyzen J, Awad N, Wood M, Shakespeare TP
J Med Imaging Radiat Oncol 2019 Dec;63(6):836-841. Epub 2019 Sep 13 doi: 10.1111/1754-9485.12945. PMID: 31520465
Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

Prognosis

Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Rectal retractor application during image-guided dose-escalated prostate radiotherapy.
Mahdavi SR, Ghaffari H, Mofid B, Rostami A, Reiazi R, Janani L
Strahlenther Onkol 2019 Oct;195(10):923-933. Epub 2019 Mar 1 doi: 10.1007/s00066-019-01445-6. PMID: 30824942
Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy.
Saadipoor A, Razzaghdoust A, Simforoosh N, Mahdavi A, Bakhshandeh M, Moghadam M, Abdollahi H, Mofid B
Phytother Res 2019 Feb;33(2):370-378. Epub 2018 Nov 14 doi: 10.1002/ptr.6230. PMID: 30427093
Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study.
Mazeron R, Fokdal LU, Kirchheiner K, Georg P, Jastaniyah N, Šegedin B, Mahantshetty U, Hoskin P, Jürgenliemk-Schulz I, Kirisits C, Lindegaard JC, Dörr W, Haie-Meder C, Tanderup K, Pötter R; EMBRACE collaborative group
Radiother Oncol 2016 Sep;120(3):412-419. Epub 2016 Jul 7 doi: 10.1016/j.radonc.2016.06.006. PMID: 27396811
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

Clinical prediction guides

Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study.
Mazeron R, Fokdal LU, Kirchheiner K, Georg P, Jastaniyah N, Šegedin B, Mahantshetty U, Hoskin P, Jürgenliemk-Schulz I, Kirisits C, Lindegaard JC, Dörr W, Haie-Meder C, Tanderup K, Pötter R; EMBRACE collaborative group
Radiother Oncol 2016 Sep;120(3):412-419. Epub 2016 Jul 7 doi: 10.1016/j.radonc.2016.06.006. PMID: 27396811
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

Supplemental Content

Table of contents

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...