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Digestive System Carcinoma In Situ

MedGen UID:
284246
•Concept ID:
C1542107
•
Neoplastic Process
Synonym: Gastrointestinal System Carcinoma In Situ

Definition

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Carcinoma In Situ

Professional guidelines

PubMed

Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement.
Roelandt P, De Looze D, De Schepper H, Ledouble V, Surmont M, Cuming T
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):625-631. doi: 10.51821/85.4.10820. PMID: 36566372
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Adenosquamous carcinoma in situ of the anus: a case series.
Keske A, Weisman PS, Xu J
Virchows Arch 2023 Jun;482(6):993-997. Epub 2023 Apr 1 doi: 10.1007/s00428-023-03525-6. PMID: 37004554
Submucosal gland neoplasms of the esophagus: an update and review.
Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256Free PMC Article
Value of endoscopy for early diagnosis of pancreatic carcinoma.
Yamashita Y, Kitano M, Ashida R
Dig Endosc 2020 Jan;32(1):27-36. Epub 2019 Jul 25 doi: 10.1111/den.13467. PMID: 31219200
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Diagnosis

Gene fusions in gastrointestinal tract cancers.
Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225
Value of endoscopy for early diagnosis of pancreatic carcinoma.
Yamashita Y, Kitano M, Ashida R
Dig Endosc 2020 Jan;32(1):27-36. Epub 2019 Jul 25 doi: 10.1111/den.13467. PMID: 31219200
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

Textbook outcomes in liver surgery for gallbladder cancer patients treated with curative-intent resection: a multicenter observational study.
Liu ZP, Guo W, Yin DL, Chen WY, Wang JY, Li XL, Yue P, Yu C, Wu ZP, Ding R, Zhu Y, Huang F, Zhou JX, Zhang D, Chen W, Jiang Y, Bai J, Wang JJ, Zhang YQ, Dai HS, Lau WY, Chen ZY
Int J Surg 2023 Sep 1;109(9):2751-2761. doi: 10.1097/JS9.0000000000000510. PMID: 37288584Free PMC Article
Phase II study (KAMELEON) of single-agent T-DM1 in patients with HER2-positive advanced urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma.
de Vries EGE, Rüschoff J, Lolkema M, Tabernero J, Gianni L, Voest E, de Groot DJA, Castellano D, Erb G, Naab J, Donica M, Deurloo R, van der Heijden MS, Viale G
Cancer Med 2023 Jun;12(11):12071-12083. Epub 2023 Apr 29 doi: 10.1002/cam4.5893. PMID: 37119523Free PMC Article
Advanced endoscopy imaging in inflammatory bowel diseases.
Kiesslich R, Neurath MF
Gastrointest Endosc 2017 Mar;85(3):496-508. Epub 2016 Nov 2 doi: 10.1016/j.gie.2016.10.034. PMID: 27816496
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Gene fusions in gastrointestinal tract cancers.
Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225
Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.
Saviano A, Henderson NC, Baumert TF
J Hepatol 2020 Nov;73(5):1219-1230. Epub 2020 Jun 10 doi: 10.1016/j.jhep.2020.06.004. PMID: 32534107Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Clinical prediction guides

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
MiR-126 in Hepatocellular Carcinoma and Cholangiocellular Carcinoma: A Reappraisal with an in situ Detection of miR-126.
Zailaie SA, Sergi CM
Ann Clin Lab Sci 2022 Jan;52(1):73-85. PMID: 35181620
Role and mechanism of circ-PRKCI in hepatocellular carcinoma.
Qi SX, Sun H, Liu H, Yu J, Jiang ZY, Yan P
World J Gastroenterol 2019 Apr 28;25(16):1964-1974. doi: 10.3748/wjg.v25.i16.1964. PMID: 31086464Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
The incidence of malignancy in the residual rectum of IBD patients after colectomy: a systematic review and meta-analysis.
Georganta I, McIntosh S, Boldovjakova D, Parnaby CN, Watson AJM, Ramsay G
Tech Coloproctol 2023 Sep;27(9):699-712. Epub 2023 Mar 12 doi: 10.1007/s10151-023-02762-w. PMID: 36906886Free PMC Article
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: a systematic review and meta-analysis.
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article

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