U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Digestive System Carcinoma In Situ

MedGen UID:
284246
•Concept ID:
C1542107
•
Neoplastic Process
Synonym: Gastrointestinal System Carcinoma In Situ

Definition

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Carcinoma In Situ

Professional guidelines

PubMed

Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement.
Roelandt P, De Looze D, De Schepper H, Ledouble V, Surmont M, Cuming T
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):625-631. doi: 10.51821/85.4.10820. PMID: 36566372
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Genome-wide DNA methylation and transcriptomic patterns of precancerous gastric cardia lesions.
Liao X, Lin R, Zhang Z, Tian D, Liu Z, Chen S, Xu G, Su M
J Natl Cancer Inst 2024 May 8;116(5):681-693. doi: 10.1093/jnci/djad244. PMID: 38258659
Premalignant/malignant histology in excised choledochal cyst specimens from children. Experience and literature review.
Okazaki T, Nikai K, Koga H, Miyano G, Ochi T, Lane GJ, Fukumura Y, Yamataka A
Pediatr Surg Int 2023 Nov 23;40(1):5. doi: 10.1007/s00383-023-05582-z. PMID: 37996760
Adenosquamous carcinoma in situ of the anus: a case series.
Keske A, Weisman PS, Xu J
Virchows Arch 2023 Jun;482(6):993-997. Epub 2023 Apr 1 doi: 10.1007/s00428-023-03525-6. PMID: 37004554
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM
Proc Natl Acad Sci U S A 2016 Mar 15;113(11):3078-83. Epub 2016 Feb 29 doi: 10.1073/pnas.1512603113. PMID: 26929329Free PMC Article
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Genome-wide DNA methylation and transcriptomic patterns of precancerous gastric cardia lesions.
Liao X, Lin R, Zhang Z, Tian D, Liu Z, Chen S, Xu G, Su M
J Natl Cancer Inst 2024 May 8;116(5):681-693. doi: 10.1093/jnci/djad244. PMID: 38258659
Gene fusions in gastrointestinal tract cancers.
Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Phase II study (KAMELEON) of single-agent T-DM1 in patients with HER2-positive advanced urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma.
de Vries EGE, Rüschoff J, Lolkema M, Tabernero J, Gianni L, Voest E, de Groot DJA, Castellano D, Erb G, Naab J, Donica M, Deurloo R, van der Heijden MS, Viale G
Cancer Med 2023 Jun;12(11):12071-12083. Epub 2023 Apr 29 doi: 10.1002/cam4.5893. PMID: 37119523Free PMC Article
Clonally expanded EOMES(+) Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M
Nat Immunol 2021 Jun;22(6):735-745. Epub 2021 May 20 doi: 10.1038/s41590-021-00930-4. PMID: 34017124
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM
Proc Natl Acad Sci U S A 2016 Mar 15;113(11):3078-83. Epub 2016 Feb 29 doi: 10.1073/pnas.1512603113. PMID: 26929329Free PMC Article
Case-control study of human papillomavirus and oropharyngeal cancer.
D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
N Engl J Med 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497. PMID: 17494927
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Dysplasia and Early Carcinoma of the Gallbladder and Bile Ducts: Terminology, Classification, and Significance.
Adsay NV, Basturk O
Gastroenterol Clin North Am 2024 Mar;53(1):85-108. Epub 2023 Nov 17 doi: 10.1016/j.gtc.2023.10.001. PMID: 38280752
Gene fusions in gastrointestinal tract cancers.
Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225
Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.
Saviano A, Henderson NC, Baumert TF
J Hepatol 2020 Nov;73(5):1219-1230. Epub 2020 Jun 10 doi: 10.1016/j.jhep.2020.06.004. PMID: 32534107Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Role of the fatty pancreatic infiltration in pancreatic oncogenesis.
Frendi S, Martineau C, Cazier H, Nicolle R, Chassac A, Albuquerque M, Raffenne J, Le Faouder J, Paradis V, Cros J, Couvelard A, Rebours V
Sci Rep 2024 Mar 19;14(1):6582. doi: 10.1038/s41598-024-57294-6. PMID: 38503902Free PMC Article
Genome-wide DNA methylation and transcriptomic patterns of precancerous gastric cardia lesions.
Liao X, Lin R, Zhang Z, Tian D, Liu Z, Chen S, Xu G, Su M
J Natl Cancer Inst 2024 May 8;116(5):681-693. doi: 10.1093/jnci/djad244. PMID: 38258659
JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.
Xie L, Chen H, Zhang L, Ma Y, Zhou Y, Yang YY, Liu C, Wang YL, Yan YJ, Ding J, Teng X, Yang Q, Liu XP, Wu J
Clin Mol Hepatol 2024 Apr;30(2):206-224. Epub 2024 Jan 8 doi: 10.3350/cmh.2023.0506. PMID: 38190829Free PMC Article
Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
The incidence of malignancy in the residual rectum of IBD patients after colectomy: a systematic review and meta-analysis.
Georganta I, McIntosh S, Boldovjakova D, Parnaby CN, Watson AJM, Ramsay G
Tech Coloproctol 2023 Sep;27(9):699-712. Epub 2023 Mar 12 doi: 10.1007/s10151-023-02762-w. PMID: 36906886Free PMC Article
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: a systematic review and meta-analysis.
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...