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Mucinous adenocarcinoma

MedGen UID:
2844
•Concept ID:
C0007130
•
Neoplastic Process
Synonyms: Adenocarcinoma of the appendix; Colonic type adenocarcinoma; Nonmucinous adenocarcinoma
SNOMED CT: Mucinous adenocarcinoma (72495009); Mucous carcinoma (72495009); Mucinous carcinoma (72495009); Colloid adenocarcinoma (72495009); Colloid carcinoma (72495009); Gelatinous adenocarcinoma (72495009); Gelatinous carcinoma (72495009); Mucoid adenocarcinoma (72495009); Mucoid carcinoma (72495009); Mucous adenocarcinoma (72495009); Pseudomyxoma peritonei with unknown primary site (72495009)
 
Monarch Initiative: MONDO:0004957

Definition

An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucinous adenocarcinoma

Professional guidelines

PubMed

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.
Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T
Cell Rep 2023 Mar 28;42(3):112212. Epub 2023 Mar 6 doi: 10.1016/j.celrep.2023.112212. PMID: 36870059
Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Mucinous breast cancer: A narrative review of the literature and a retrospective tertiary single-centre analysis.
Marrazzo E, Frusone F, Milana F, Sagona A, Gatzemeier W, Barbieri E, Bottini A, Canavese G, Rubino AO, Eboli MG, Rossetti CM, Testori A, Errico V, De Luca A, Tinterri C
Breast 2020 Feb;49:87-92. Epub 2019 Nov 11 doi: 10.1016/j.breast.2019.11.002. PMID: 31783314Free PMC Article
Mucinous adenocarcinoma of the colon and rectum: A genomic analysis.
Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP
J Surg Oncol 2019 Dec;120(8):1427-1435. Epub 2019 Nov 14 doi: 10.1002/jso.25764. PMID: 31729037
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cervical Glandular Neoplasia: Classification and Staging.
Turashvili G, Park KJ
Surg Pathol Clin 2019 Jun;12(2):281-313. doi: 10.1016/j.path.2019.01.002. PMID: 31097105

Diagnosis

Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
Neonatal congenital pulmonary airway malformation associated with mucinous adenocarcinoma and KRAS mutations.
Muntean A, Banias LE, Ade-Ajayi N, Patel SB, McKinney O, Davenport M
J Pediatr Surg 2022 Nov;57(11):520-526. Epub 2021 Dec 25 doi: 10.1016/j.jpedsurg.2021.12.018. PMID: 34980466
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Mucinous Ovarian Carcinoma.
Morice P, Gouy S, Leary A
N Engl J Med 2019 Mar 28;380(13):1256-1266. doi: 10.1056/NEJMra1813254. PMID: 30917260
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488

Therapy

Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer.
Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP
Pharmacogenomics J 2020 Jun;20(3):524-532. Epub 2019 Dec 10 doi: 10.1038/s41397-019-0137-6. PMID: 31819162
Mucinous Ovarian Carcinoma.
Morice P, Gouy S, Leary A
N Engl J Med 2019 Mar 28;380(13):1256-1266. doi: 10.1056/NEJMra1813254. PMID: 30917260
Early stage mucinous ovarian cancer: A review.
Crane EK, Brown J
Gynecol Oncol 2018 Jun;149(3):598-604. Epub 2018 Feb 9 doi: 10.1016/j.ygyno.2018.01.035. PMID: 29429591
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Mucinous ovarian cancer.
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Prognosis

Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma.
Chen Z, Li M, Ma K, Shang G, Liang J, Yin J, Luo J, Zhan C, Shi Y, Wang Q
Cancer Med 2020 Jan;9(2):517-529. Epub 2019 Nov 25 doi: 10.1002/cam4.2726. PMID: 31769218Free PMC Article
Advanced Mucinous Colorectal Cancer: Epidemiology, Prognosis and Efficacy of Chemotherapeutic Treatment.
Ott C, Gerken M, Hirsch D, Fest P, Fichtner-Feigl S, Munker S, Schnoy E, Stroszczynski C, Vogelhuber M, Herr W, Evert M, Reng M, Schlitt HJ, Klinkhammer-Schalke M, Teufel A
Digestion 2018;98(3):143-152. Epub 2018 Jun 5 doi: 10.1159/000487710. PMID: 29870979
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Clinicopathological characteristics and prognosis of mucinous breast carcinoma.
Zhang M, Teng XD, Guo XX, Zhao JS, Li ZG
J Cancer Res Clin Oncol 2014 Feb;140(2):265-9. Epub 2013 Dec 5 doi: 10.1007/s00432-013-1559-1. PMID: 24305754
Clinicopathologic features and prognosis analysis of mucinous gastric carcinoma.
Yin C, Li D, Sun Z, Zhang T, Xu Y, Wang Z, Xu H
Med Oncol 2012 Jun;29(2):864-70. Epub 2011 Feb 5 doi: 10.1007/s12032-011-9825-z. PMID: 21298368

Clinical prediction guides

Clinicopathological Characteristics of Mucinous and Non-mucinous Adenocarcinoma of the Colon and Rectum.
Eunus MF, Saleh FM, Karim SN, Tanzim MA, Hossain MI
Mymensingh Med J 2023 Apr;32(2):480-486. PMID: 37002761
Single-cell profiling reveals differences between human classical adenocarcinoma and mucinous adenocarcinoma.
Hu FJ, Li YJ, Zhang L, Ji DB, Liu XZ, Chen YJ, Wang L, Wu AW
Commun Biol 2023 Jan 23;6(1):85. doi: 10.1038/s42003-023-04441-w. PMID: 36690709Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent systematic reviews

Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms.
Wood LD, Adsay NV, Basturk O, Brosens LAA, Fukushima N, Hong SM, Kim SJ, Lee JW, Luchini C, Noë M, Pitman MB, Scarpa A, Singhi AD, Tanaka M, Furukawa T
Pancreatology 2023 Nov;23(7):878-891. Epub 2023 Aug 11 doi: 10.1016/j.pan.2023.08.002. PMID: 37604731
Uptake and Outcomes of Neoadjuvant Chemotherapy Among US Patients With Less Common Epithelial Ovarian Carcinomas.
Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370
Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis.
Verhulst J, Ferdinande L, Demetter P, Ceelen W
J Clin Pathol 2012 May;65(5):381-8. Epub 2012 Jan 18 doi: 10.1136/jclinpath-2011-200340. PMID: 22259177
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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