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Grade 3 Nausea, CTCAE

MedGen UID:
284614
•Concept ID:
C1556474
•
Finding

Definition

Inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Nausea, CTCAE

Professional guidelines

PubMed

Management of sotorasib-related adverse events and hepatotoxicities following anti-PD-(L)1 therapy: Experience with sotorasib in two French anti-cancer centers and practical guidance proposal.
Chour A, Basse C, Lebossé F, Bonte PE, Girard N, Duruisseaux M
Lung Cancer 2024 May;191:107789. Epub 2024 Apr 9 doi: 10.1016/j.lungcan.2024.107789. PMID: 38614068
Identifying Severe Adverse Event Clusters Using the National Cancer Institute's Common Terminology Criteria for Adverse Events.
Zhong X, Lim EA, Hershman DL, Moinpour CM, Unger J, Lee SM
J Oncol Pract 2016 Mar;12(3):e270-80, 245-6. Epub 2016 Feb 23 doi: 10.1200/JOP.2015.006106. PMID: 26907453Free PMC Article
Treatment tolerance of particle therapy in pediatric patients.
Rieber JG, Kessel KA, Witt O, Behnisch W, Kulozik AE, Debus J, Combs SE
Acta Oncol 2015 Jul;54(7):1049-55. Epub 2015 Jan 23 doi: 10.3109/0284186X.2014.998273. PMID: 25615893

Recent clinical studies

Etiology

Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study.
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Angiographic Anatomy and Relevance of 3 and 9 O'clock Arteries During Radioembolization.
Powerski M, Bascik B, Omari J, El-Sanosy S, Grosser OS, Seidensticker M, Fischbach F, Pech M
Cardiovasc Intervent Radiol 2018 Jun;41(6):890-897. Epub 2018 Jan 17 doi: 10.1007/s00270-017-1873-0. PMID: 29344714

Diagnosis

Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
Lack of Concordance in Symptomatic Adverse Event Reporting by Children, Clinicians, and Caregivers: Implications for Cancer Clinical Trials.
Freyer DR, Lin L, Mack JW, Maurer SH, McFatrich M, Baker JN, Jacobs SS, Lucas N, Withycombe JS, Tomlinson D, Villabroza KR, Waldron MK, Hinds PS, Reeve BB
J Clin Oncol 2022 May 20;40(15):1623-1634. Epub 2022 Mar 16 doi: 10.1200/JCO.21.02669. PMID: 35294262Free PMC Article
Efficacy of venlafaxine for the relief of taxane and oxaliplatin-induced acute neurotoxicity: a single-center retrospective case-control study.
Kus T, Aktas G, Alpak G, Kalender ME, Sevinc A, Kul S, Temizer M, Camci C
Support Care Cancer 2016 May;24(5):2085-2091. Epub 2015 Nov 7 doi: 10.1007/s00520-015-3009-x. PMID: 26546457
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Evaluation of interobserver and interscale agreement in assessing late bowel toxicity after pelvic radiation in patients with carcinoma of the cervix.
Chinnachamy AN, Chopra S, Krishnatry R, Kannan S, Thomas B, Mahantshetty U, Engineer R, Shrivastava SK
Jpn J Clin Oncol 2013 May;43(5):508-14. Epub 2013 Mar 20 doi: 10.1093/jjco/hyt028. PMID: 23515269

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study.
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Angiographic Anatomy and Relevance of 3 and 9 O'clock Arteries During Radioembolization.
Powerski M, Bascik B, Omari J, El-Sanosy S, Grosser OS, Seidensticker M, Fischbach F, Pech M
Cardiovasc Intervent Radiol 2018 Jun;41(6):890-897. Epub 2018 Jan 17 doi: 10.1007/s00270-017-1873-0. PMID: 29344714
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

Prognosis

Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Lack of Concordance in Symptomatic Adverse Event Reporting by Children, Clinicians, and Caregivers: Implications for Cancer Clinical Trials.
Freyer DR, Lin L, Mack JW, Maurer SH, McFatrich M, Baker JN, Jacobs SS, Lucas N, Withycombe JS, Tomlinson D, Villabroza KR, Waldron MK, Hinds PS, Reeve BB
J Clin Oncol 2022 May 20;40(15):1623-1634. Epub 2022 Mar 16 doi: 10.1200/JCO.21.02669. PMID: 35294262Free PMC Article
Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity.
Kaneko S, Kurosaki M, Nagata K, Taki R, Ueda K, Hanada S, Takayama K, Suzaki S, Harada N, Sugiyama T, Nagasawa M, Izumi N
PLoS One 2020;15(11):e0241663. Epub 2020 Nov 4 doi: 10.1371/journal.pone.0241663. PMID: 33147270Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Clinical prediction guides

Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms.
Hauch H, Wolff BJ, Wolff JE
Anticancer Res 2022 Jan;42(1):45-52. doi: 10.21873/anticanres.15455. PMID: 34969707
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

Recent systematic reviews

Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms.
Hauch H, Wolff BJ, Wolff JE
Anticancer Res 2022 Jan;42(1):45-52. doi: 10.21873/anticanres.15455. PMID: 34969707
A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.
Sadaghiani MS, Sheikhbahaei S, Werner RA, Pienta KJ, Pomper MG, Solnes LB, Gorin MA, Wang NY, Rowe SP
Eur Urol 2021 Jul;80(1):82-94. Epub 2021 Apr 8 doi: 10.1016/j.eururo.2021.03.004. PMID: 33840558Free PMC Article
Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

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