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Grade 4 Colon or Cecum or Appendix Fistula, CTCAE

MedGen UID:
286799
•Concept ID:
C1560369
•
Finding
Synonym: CTCAE Grade 4 Colon/cecum/appendix fistula

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Colon or Cecum or Appendix Fistula, CTCAE

Professional guidelines

PubMed

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.
Schneider BJ, Naidoo J, Santomasso BD, Lacchetti C, Adkins S, Anadkat M, Atkins MB, Brassil KJ, Caterino JM, Chau I, Davies MJ, Ernstoff MS, Fecher L, Ghosh M, Jaiyesimi I, Mammen JS, Naing A, Nastoupil LJ, Phillips T, Porter LD, Reichner CA, Seigel C, Song JM, Spira A, Suarez-Almazor M, Swami U, Thompson JA, Vikas P, Wang Y, Weber JS, Funchain P, Bollin K
J Clin Oncol 2021 Dec 20;39(36):4073-4126. Epub 2021 Nov 1 doi: 10.1200/JCO.21.01440. PMID: 34724392
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network
J Clin Oncol 2018 Jun 10;36(17):1714-1768. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.77.6385. PMID: 29442540Free PMC Article
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article

Recent clinical studies

Etiology

Antibiotics for uncomplicated diverticulitis.
Dichman ML, Rosenstock SJ, Shabanzadeh DM
Cochrane Database Syst Rev 2022 Jun 22;6(6):CD009092. doi: 10.1002/14651858.CD009092.pub3. PMID: 35731704Free PMC Article
Infrapyloric and gastroepiploic node dissection for hepatic flexure and transverse colon cancer: A systematic review.
Piozzi GN, Rusli SM, Baek SJ, Kwak JM, Kim J, Kim SH
Eur J Surg Oncol 2022 Apr;48(4):718-726. Epub 2021 Dec 4 doi: 10.1016/j.ejso.2021.12.005. PMID: 34893366
Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
Cecoproctostomy.
Ryan JA Jr, Oakley WC
Am J Surg 1985 May;149(5):636-9. doi: 10.1016/s0002-9610(85)80145-8. PMID: 3993845

Diagnosis

Antibiotics for uncomplicated diverticulitis.
Dichman ML, Rosenstock SJ, Shabanzadeh DM
Cochrane Database Syst Rev 2022 Jun 22;6(6):CD009092. doi: 10.1002/14651858.CD009092.pub3. PMID: 35731704Free PMC Article
Snapshot quiz.
Br J Surg 2021 Apr 5;108(3):314. doi: 10.1093/bjs/znaa080. PMID: 33822881
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Vascular anomalies of the large bowel.
Pellino G, Candilio G, De Fatico GS, Marcellinaro R, Piccione A, Cautiero R, Capozzolo A, Guerniero R, Volpicelli A, Reginelli A, Corvino A, Sciaudone G, Canonico S, Selvaggi F
Int Angiol 2015 Dec;34(6 Suppl 1):23-7. PMID: 26498888
The vermiform appendix: a review.
Barlow A, Muhleman M, Gielecki J, Matusz P, Tubbs RS, Loukas M
Clin Anat 2013 Oct;26(7):833-42. Epub 2013 May 29 doi: 10.1002/ca.22269. PMID: 23716128

Therapy

Antibiotics for uncomplicated diverticulitis.
Dichman ML, Rosenstock SJ, Shabanzadeh DM
Cochrane Database Syst Rev 2022 Jun 22;6(6):CD009092. doi: 10.1002/14651858.CD009092.pub3. PMID: 35731704Free PMC Article
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
The vermiform appendix: an immunological organ sustaining a microbiome inoculum.
Vitetta L, Chen J, Clarke S
Clin Sci (Lond) 2019 Jan 15;133(1):1-8. Epub 2019 Jan 3 doi: 10.1042/CS20180956. PMID: 30606811
Water-aided colonoscopy.
Anderson JC
Gastrointest Endosc Clin N Am 2015 Apr;25(2):211-26. Epub 2015 Feb 11 doi: 10.1016/j.giec.2014.11.002. PMID: 25839683

Prognosis

Neurogenic appendicopathy: an underestimated disease-systematic review of the literature.
Peisl S, Burckhardt O, Egger B
Int J Colorectal Dis 2021 Sep;36(9):1995-2005. Epub 2021 Apr 10 doi: 10.1007/s00384-021-03901-1. PMID: 33839889
Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial.
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Appendicitis.
D'Souza N
BMJ Clin Evid 2011 Jan 7;2011 PMID: 21477397Free PMC Article

Clinical prediction guides

Clinical value of sigmoid colon water exchange colonoscopy: a prospective randomized clinical trial.
Jiao TX, Hu Y, Guo SB
Sci Rep 2023 Aug 22;13(1):13704. doi: 10.1038/s41598-023-40706-4. PMID: 37608083Free PMC Article
EXTRACOLONIC FINDINGS-IDENTIFICATION AT LOW-DOSE CTC.
Thorén F, Johnsson ÅA, Hellström M, Båth M
Radiat Prot Dosimetry 2021 Oct 12;195(3-4):188-197. doi: 10.1093/rpd/ncab054. PMID: 33855447Free PMC Article
Overview of the ultrasonography techniques in the diagnosis of appendicitis - elaboration of a novel anatomy scanning method.
Ge H, Miao L, Zhang F, Lin Z, Zhang L, Dou R, Fang N, Song K
Med Ultrason 2020 Sep 5;22(3):334-344. doi: 10.11152/mu-2541. PMID: 32898205
Ilececum: A Comprehensive Review.
Tang SJ, Wu R
Can J Gastroenterol Hepatol 2019;2019:1451835. Epub 2019 Feb 3 doi: 10.1155/2019/1451835. PMID: 30854348Free PMC Article
Development and validation of the Nancy histological index for UC.
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold MD, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L
Gut 2017 Jan;66(1):43-49. Epub 2015 Oct 13 doi: 10.1136/gutjnl-2015-310187. PMID: 26464414

Recent systematic reviews

Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery.
Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO
Cochrane Database Syst Rev 2023 Feb 7;2(2):CD014909. doi: 10.1002/14651858.CD014909.pub2. PMID: 36748942Free PMC Article
Antibiotics for uncomplicated diverticulitis.
Dichman ML, Rosenstock SJ, Shabanzadeh DM
Cochrane Database Syst Rev 2022 Jun 22;6(6):CD009092. doi: 10.1002/14651858.CD009092.pub3. PMID: 35731704Free PMC Article
Short-term outcomes in robot-assisted compared to laparoscopic colon cancer resections: a systematic review and meta-analysis.
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Appendicitis.
D'Souza N, Nugent K
BMJ Clin Evid 2014 Dec 8;2014 PMID: 25486014Free PMC Article
Appendicitis.
D'Souza N
BMJ Clin Evid 2011 Jan 7;2011 PMID: 21477397Free PMC Article

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