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Grade 2 Ileus, CTCAE

MedGen UID:
286819
•Concept ID:
C1560458
•
Finding
Synonym: CTCAE Grade 2 Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)

Definition

Symptomatic; altered GI function; bowel rest indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Ileus, CTCAE

Recent clinical studies

Etiology

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.
Lehmann K, Eshmuminov D, Slankamenac K, Kranzbühler B, Clavien PA, Vonlanthen R, Gertsch P
World J Surg 2016 May;40(5):1075-81. doi: 10.1007/s00268-015-3366-0. PMID: 26669784
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383

Diagnosis

Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.
Lehmann K, Eshmuminov D, Slankamenac K, Kranzbühler B, Clavien PA, Vonlanthen R, Gertsch P
World J Surg 2016 May;40(5):1075-81. doi: 10.1007/s00268-015-3366-0. PMID: 26669784

Therapy

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.
Lehmann K, Eshmuminov D, Slankamenac K, Kranzbühler B, Clavien PA, Vonlanthen R, Gertsch P
World J Surg 2016 May;40(5):1075-81. doi: 10.1007/s00268-015-3366-0. PMID: 26669784
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383
Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma: a feasibility study.
Nagao S, Iwasa N, Kurosaki A, Nishikawa T, Ohishi R, Hasegawa K, Goto T, Fujiwara K
Int J Gynecol Cancer 2012 Jan;22(1):70-5. doi: 10.1097/IGC.0b013e318234f927. PMID: 22146766

Prognosis

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383

Clinical prediction guides

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.
Lehmann K, Eshmuminov D, Slankamenac K, Kranzbühler B, Clavien PA, Vonlanthen R, Gertsch P
World J Surg 2016 May;40(5):1075-81. doi: 10.1007/s00268-015-3366-0. PMID: 26669784
Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma: a feasibility study.
Nagao S, Iwasa N, Kurosaki A, Nishikawa T, Ohishi R, Hasegawa K, Goto T, Fujiwara K
Int J Gynecol Cancer 2012 Jan;22(1):70-5. doi: 10.1097/IGC.0b013e318234f927. PMID: 22146766

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