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Basal cell carcinoma

MedGen UID:
2870
Concept ID:
C0007117
Neoplastic Process
Synonyms: basal cell cancer; Basal Cell Carcinoma; basal cell carcinoma; Basiloma; BCC - Basal cell carcinoma; epithelioma, basal cell; malignant basal cell neoplasm; Rodent ulcer
SNOMED CT: BCC - Basal cell carcinoma (1338007); Basal cell carcinoma (1338007); Rodent ulcer (1338007); Basiloma (1338007)
 
Monarch Initiative: MONDO:0020804

Definition

A carcinoma involving the basal cells. [from NCI]

Professional guidelines

PubMed

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
Basset-Seguin N, Herms F
Acta Derm Venereol 2020 Jun 3;100(11):adv00140. doi: 10.2340/00015555-3495. PMID: 32346750Free PMC Article
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Basal Cell Skin Cancer, 2023

Suggested Reading

Recent clinical studies

Etiology

Heath MS, Bar A
Dermatol Clin 2023 Jan;41(1):13-21. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.005. PMID: 36410973
Basset-Seguin N, Herms F
Acta Derm Venereol 2020 Jun 3;100(11):adv00140. doi: 10.2340/00015555-3495. PMID: 32346750Free PMC Article
Kim DP, Kus KJB, Ruiz E
Hematol Oncol Clin North Am 2019 Feb;33(1):13-24. doi: 10.1016/j.hoc.2018.09.004. PMID: 30497670
Linares MA, Zakaria A, Nizran P
Prim Care 2015 Dec;42(4):645-59. doi: 10.1016/j.pop.2015.07.006. PMID: 26612377
Marzuka AG, Book SE
Yale J Biol Med 2015 Jun;88(2):167-79. Epub 2015 Jun 1 PMID: 26029015Free PMC Article

Diagnosis

Heath MS, Bar A
Dermatol Clin 2023 Jan;41(1):13-21. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.005. PMID: 36410973
Usatine RP, Heath CR
Cutis 2022 Jun;109(6):339-340. doi: 10.12788/cutis.0540. PMID: 35960981
Álvarez-Salafranca M, Ara M, Zaballos P
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):330-338. Epub 2020 Nov 28 doi: 10.1016/j.ad.2020.11.011. PMID: 33259816
Kim DP, Kus KJB, Ruiz E
Hematol Oncol Clin North Am 2019 Feb;33(1):13-24. doi: 10.1016/j.hoc.2018.09.004. PMID: 30497670
Marzuka AG, Book SE
Yale J Biol Med 2015 Jun;88(2):167-79. Epub 2015 Jun 1 PMID: 26029015Free PMC Article

Therapy

Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Cameron MC, Lee E, Hibler BP, Giordano CN, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM
J Am Acad Dermatol 2019 Feb;80(2):321-339. Epub 2018 May 19 doi: 10.1016/j.jaad.2018.02.083. PMID: 29782901
Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL
N Engl J Med 2015 Oct 22;373(17):1618-26. doi: 10.1056/NEJMoa1506197. PMID: 26488693

Prognosis

Hedberg ML, Berry CT, Moshiri AS, Xiang Y, Yeh CJ, Attilasoy C, Capell BC, Seykora JT
Int J Mol Sci 2022 Mar 23;23(7) doi: 10.3390/ijms23073478. PMID: 35408839Free PMC Article
Leiter U, Keim U, Garbe C
Adv Exp Med Biol 2020;1268:123-139. doi: 10.1007/978-3-030-46227-7_6. PMID: 32918216
Kim DP, Kus KJB, Ruiz E
Hematol Oncol Clin North Am 2019 Feb;33(1):13-24. doi: 10.1016/j.hoc.2018.09.004. PMID: 30497670
Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM
J Am Acad Dermatol 2019 Feb;80(2):303-317. Epub 2018 May 18 doi: 10.1016/j.jaad.2018.03.060. PMID: 29782900
Lomas A, Leonardi-Bee J, Bath-Hextall F
Br J Dermatol 2012 May;166(5):1069-80. doi: 10.1111/j.1365-2133.2012.10830.x. PMID: 22251204

Clinical prediction guides

Damsin T, Lebas E, Marchal N, Rorive A, Nikkels AF
Expert Rev Anticancer Ther 2022 Mar;22(3):243-248. Epub 2022 Feb 22 doi: 10.1080/14737140.2022.2043748. PMID: 35175882
Sharma P, Wadhwan V, Bansal V
Indian J Dent Res 2021 Jul-Sep;32(3):407-410. doi: 10.4103/ijdr.IJDR_227_19. PMID: 35229784
Álvarez-Salafranca M, Ara M, Zaballos P
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):330-338. Epub 2020 Nov 28 doi: 10.1016/j.ad.2020.11.011. PMID: 33259816
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208
Cohen PR
Skinmed 2018;16(2):105-110. Epub 2018 Apr 1 PMID: 29911527

Recent systematic reviews

Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ
Cochrane Database Syst Rev 2020 Nov 17;11(11):CD003412. doi: 10.1002/14651858.CD003412.pub3. PMID: 33202063Free PMC Article
Zaorsky NG, Lee CT, Zhang E, Keith SW, Galloway TJ
Radiother Oncol 2017 Oct;125(1):13-20. Epub 2017 Aug 23 doi: 10.1016/j.radonc.2017.08.011. PMID: 28843727Free PMC Article
Lomas A, Leonardi-Bee J, Bath-Hextall F
Br J Dermatol 2012 May;166(5):1069-80. doi: 10.1111/j.1365-2133.2012.10830.x. PMID: 22251204

Supplemental Content

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    Clinical resources

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    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Basal Cell Skin Cancer, 2023

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