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Vein of Galen malformation

MedGen UID:
287069
Concept ID:
C1562503
Congenital Abnormality
Synonyms: Galen Malformations Veins; Malformations Vein, Galen; Malformations Veins, Galen; Vein Of Galen Malformation; Vein of Galen Malformations
SNOMED CT: Vein of Galen malformation (416792008)

Definition

An arteriovenous malformation in the vein of Galen that is located at the base of the brain. The malformation may result in developmental delays, hydrocephalus, seizures, and congestive heart failure. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Hosmann A, El-Garci A, Gatterbauer B, Bavinzski G, Knosp E, Gruber A
World Neurosurg 2018 Apr;112:e837-e847. Epub 2018 Feb 3 doi: 10.1016/j.wneu.2018.01.172. PMID: 29408495
Khullar D, Andeejani AM, Bulsara KR
J Neurosurg Pediatr 2010 Nov;6(5):444-51. doi: 10.3171/2010.8.PEDS10231. PMID: 21039167

Recent clinical studies

Etiology

Fifi JT, Bazil MJ, Matsoukas S, Shigematsu T, Sorscher M, Berenstein A
J Neurointerv Surg 2023 Jun;15(6):579-583. Epub 2022 Jul 14 doi: 10.1136/jnis-2022-019121. PMID: 35835461
Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Zafar A, Fiani B, Hadi H, Arshad M, Cathel A, Naeem M, Parsons MS, Farooqui M, Bucklin AA, Leone MJ, Baig A, Quadri SA
Neurol Sci 2020 Sep;41(9):2407-2421. Epub 2020 Apr 25 doi: 10.1007/s10072-020-04415-4. PMID: 32335778
Taffin H, Maurey H, Ozanne A, Durand P, Husson B, Knebel JF, Adamsbaum C, Deiva K, Saliou G
Dev Med Child Neurol 2020 Jun;62(6):729-734. Epub 2019 Nov 12 doi: 10.1111/dmcn.14392. PMID: 31713850
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722

Diagnosis

Lu VM, Luther EM, Silva MA, Rangwala SD, Starke RM, Smith ER, See AP
Childs Nerv Syst 2023 Mar;39(3):733-741. Epub 2022 Sep 23 doi: 10.1007/s00381-022-05687-1. PMID: 36149485
Nesbit GM
Handb Clin Neurol 2021;176:305-323. doi: 10.1016/B978-0-444-64034-5.00015-8. PMID: 33272401
Alexander MD, Darflinger R, Cooke DL, Halbach VV
Handb Clin Neurol 2021;176:179-198. doi: 10.1016/B978-0-444-64034-5.00004-3. PMID: 33272395
Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT
J Neurosurg Pediatr 2018 Apr;21(4):367-374. Epub 2018 Jan 19 doi: 10.3171/2017.9.PEDS17365. PMID: 29350590
Hoang S, Choudhri O, Edwards M, Guzman R
Neurosurg Focus 2009 Nov;27(5):E8. doi: 10.3171/2009.8.FOCUS09168. PMID: 19877798

Therapy

Bhatia K, Mendes Pereira V, Krings T, Ter Brugge K, Kortman H, Dirks P, Armstrong D, Shroff M, Muthusami P
JAMA Neurol 2020 Aug 1;77(8):992-999. doi: 10.1001/jamaneurol.2020.0825. PMID: 32338714Free PMC Article
Meila D, Grieb D, Melber K, Jacobs C, Maslehaty H, Petridis A, El Habony R, Lanfermann H, Scholz M, Brassel F
Acta Neurochir (Wien) 2016 Jul;158(7):1279-84. Epub 2016 May 13 doi: 10.1007/s00701-016-2836-y. PMID: 27173099
Yan J, Wen J, Gopaul R, Zhang CY, Xiao SW
J Neurosurg 2015 Oct;123(4):872-90. Epub 2015 Jul 31 doi: 10.3171/2014.12.JNS141249. PMID: 26230476
McSweeney N, Brew S, Bhate S, Cox T, Roebuck DJ, Ganesan V
Arch Dis Child 2010 Nov;95(11):903-9. Epub 2010 Jul 6 doi: 10.1136/adc.2009.177584. PMID: 20605862
Sinha PK, Neema PK, Rathod RC
Neurol India 2004 Jun;52(2):163-70. PMID: 15269462

Prognosis

Lu VM, Luther EM, Silva MA, Rangwala SD, Starke RM, Smith ER, See AP
Childs Nerv Syst 2023 Mar;39(3):733-741. Epub 2022 Sep 23 doi: 10.1007/s00381-022-05687-1. PMID: 36149485
Paramasivam S
Neurol India 2021 Nov-Dec;69(Supplement):S376-S379. doi: 10.4103/0028-3886.332279. PMID: 35102992
Taffin H, Maurey H, Ozanne A, Durand P, Husson B, Knebel JF, Adamsbaum C, Deiva K, Saliou G
Dev Med Child Neurol 2020 Jun;62(6):729-734. Epub 2019 Nov 12 doi: 10.1111/dmcn.14392. PMID: 31713850
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Hoang S, Choudhri O, Edwards M, Guzman R
Neurosurg Focus 2009 Nov;27(5):E8. doi: 10.3171/2009.8.FOCUS09168. PMID: 19877798

Clinical prediction guides

Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Taffin H, Maurey H, Ozanne A, Durand P, Husson B, Knebel JF, Adamsbaum C, Deiva K, Saliou G
Dev Med Child Neurol 2020 Jun;62(6):729-734. Epub 2019 Nov 12 doi: 10.1111/dmcn.14392. PMID: 31713850
Zeng X, Hunt A, Jin SC, Duran D, Gaillard J, Kahle KT
Trends Mol Med 2019 Apr;25(4):265-286. Epub 2019 Feb 25 doi: 10.1016/j.molmed.2019.01.009. PMID: 30819650Free PMC Article
Gopalan V, Rennie A, Robertson F, Kanagarajah L, Toolis C, Bhate S, Ganesan V
Dev Med Child Neurol 2018 Apr;60(4):424-429. Epub 2018 Jan 23 doi: 10.1111/dmcn.13676. PMID: 29359331
McSweeney N, Brew S, Bhate S, Cox T, Roebuck DJ, Ganesan V
Arch Dis Child 2010 Nov;95(11):903-9. Epub 2010 Jul 6 doi: 10.1136/adc.2009.177584. PMID: 20605862

Recent systematic reviews

Yan J, Wen J, Gopaul R, Zhang CY, Xiao SW
J Neurosurg 2015 Oct;123(4):872-90. Epub 2015 Jul 31 doi: 10.3171/2014.12.JNS141249. PMID: 26230476

Supplemental Content

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