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Scirrhous adenocarcinoma

MedGen UID:
2873
•Concept ID:
C0007135
•
Neoplastic Process
Synonyms: Adenocarcinoma, Scirrhous; Adenocarcinomas, Scirrhous; Carcinoma, Scirrhous; Carcinomas, Scirrhous; Scirrhous Adenocarcinoma; Scirrhous Adenocarcinomas; Scirrhous Carcinoma; Scirrhous Carcinomas
SNOMED CT: Scirrhous adenocarcinoma (4584002); Scirrhous carcinoma (4584002); Carcinoma with productive fibrosis (4584002)
 
Monarch Initiative: MONDO:0005953

Definition

An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVScirrhous adenocarcinoma

Professional guidelines

PubMed

The Genomic Signatures of Linitis Plastica Signal the Entrance into a New Era: Novel Approaches for Diagnosis and Treatment.
Christodoulidis G, Koumarelas KE, Kouliou MN, Samara M, Thodou E, Zacharoulis D
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914680. PMID: 37834127Free PMC Article
Familial gastric and pancreatic cancers: Diagnosis and screening.
Raymond VM, Stoffel EM
Am Soc Clin Oncol Educ Book 2013 doi: 10.14694/EdBook_AM.2013.33.e44. PMID: 23714452
Giant gastric folds: differential diagnosis at US.
Okanobu H, Hata J, Haruma K, Hara M, Nakamura K, Tanaka S, Chayama K
Radiology 2003 Mar;226(3):686-90. Epub 2003 Jan 24 doi: 10.1148/radiol.2263012080. PMID: 12601220

Recent clinical studies

Etiology

Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Scirrhous gastric carcinoma: endoscopy versus upper gastrointestinal radiography.
Park MS, Ha HK, Choi BS, Kim KW, Myung SJ, Kim AY, Kim TK, Kim PN, Lee NJ, Lee JK, Lee MG, Kim JH
Radiology 2004 May;231(2):421-6. doi: 10.1148/radiol.2312030248. PMID: 15128987
Scirrhous carcinoma of the stomach: a clinical and pathological study of 106 surgical cases.
Hirose S, Honjou H, Nakagawa H, Nishimura K, Kuroda Y, Tsuji M, Miwa A, Kitagawa M
Gastroenterol Jpn 1989 Oct;24(5):481-7. doi: 10.1007/BF02773873. PMID: 2553523
Mach bands in mammography.
Gordenne WH, Malchair FL
Radiology 1988 Oct;169(1):55-8. doi: 10.1148/radiology.169.1.2843941. PMID: 2843941
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

Diagnosis

Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
Mod Pathol 2013 Jun;26(6):782-91. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.243. PMID: 23348905
Breast mass.
Merrick CW, Press HC Jr
J Natl Med Assoc 1979 Apr;71(4):403-4. PMID: 220432Free PMC Article
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528
Ultrasound mammography.
Baum G
Radiology 1977 Jan;122(1):199-205. doi: 10.1148/122.1.199. PMID: 186842
MAMMOGRAPHY OF CANCER.
GERSHON-COHEN J, FORMAN M
Bull N Y Acad Med 1964 Sep;40(9):674-89. PMID: 14172056Free PMC Article

Therapy

Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?
Yasui W
Ann Surg Oncol 2019 Apr;26(4):926-927. Epub 2019 Jan 8 doi: 10.1245/s10434-018-07146-1. PMID: 30623340
Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Recent results of therapy for scirrhous gastric cancer.
Ikeguchi M, Miyake T, Matsunaga T, Yamamoto M, Fukumoto Y, Yamada Y, Fukuda K, Saito H, Tatebe S, Tsujitani S
Surg Today 2009;39(4):290-4. Epub 2009 Mar 25 doi: 10.1007/s00595-008-3860-1. PMID: 19319634
Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.
Murahashi K, Yashiro M, Inoue T, Nishimura S, Matsuoka T, Sawada T, Sowa M, Hirakawa-Ys Chung K
Int J Oncol 1998 Dec;13(6):1235-40. doi: 10.3892/ijo.13.6.1235. PMID: 9824637
Aspiration of breast cysts.
Dohrmann PJ, Hughes ES, McDermott FT, Price AB
Aust N Z J Surg 1982 Dec;52(6):605-7. doi: 10.1111/j.1445-2197.1982.tb06123.x. PMID: 6299260

Prognosis

Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.
Sera T, Sakuma T, Maruo K, Tsujio G, Yamamoto Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Kasashima H, Ohira M, Maeda K
Anticancer Res 2022 Nov;42(11):5195-5203. doi: 10.21873/anticanres.16026. PMID: 36288877
Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy.
Yoshikawa T, Rino Y, Yukawa N, Oshima T, Tsuburaya A, Masuda M
Surg Today 2014 Jan;44(1):11-21. Epub 2013 Mar 19 doi: 10.1007/s00595-013-0529-1. PMID: 23508452
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
Mod Pathol 2013 Jun;26(6):782-91. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.243. PMID: 23348905
Clinicopathologic characteristics and long-term prognosis of scirrhous hepatocellular carcinoma.
Lee JH, Choi MS, Gwak GY, Lee JH, Koh KC, Paik SW, Yoo BC, Choi D, Park CK
Dig Dis Sci 2012 Jun;57(6):1698-707. Epub 2012 Feb 11 doi: 10.1007/s10620-012-2075-x. PMID: 22327241
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

Clinical prediction guides

Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.
Sera T, Sakuma T, Maruo K, Tsujio G, Yamamoto Y, Sugimoto A, Kushiyama S, Togano S, Kuroda K, Kasashima H, Ohira M, Maeda K
Anticancer Res 2022 Nov;42(11):5195-5203. doi: 10.21873/anticanres.16026. PMID: 36288877
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
Mod Pathol 2013 Jun;26(6):782-91. Epub 2013 Jan 25 doi: 10.1038/modpathol.2012.243. PMID: 23348905
Mach bands in mammography.
Gordenne WH, Malchair FL
Radiology 1988 Oct;169(1):55-8. doi: 10.1148/radiology.169.1.2843941. PMID: 2843941
Vitamin C and cancer: an overview.
Cameron E
Int J Vitam Nutr Res Suppl 1982;23:115-27. PMID: 6180998
Pregnancy and breast cancer.
Hubay CA, Barry FM, Marr CC
Surg Clin North Am 1978 Aug;58(4):819-31. doi: 10.1016/s0039-6109(16)41594-x. PMID: 210528

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