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Transitional cell carcinoma

MedGen UID:
2875
•Concept ID:
C0007138
•
Neoplastic Process
Synonyms: Carcinoma, Transitional Cell; Carcinomas, Transitional Cell; Cell Carcinoma, Transitional; Cell Carcinomas, Transitional; Transitional Cell Carcinoma; Transitional Cell Carcinomas
SNOMED CT: TCC - Transitional cell carcinoma (27090000); Transitional cell carcinoma (27090000); Transitional carcinoma (27090000); Urothelial carcinoma (27090000)
 
Monarch Initiative: MONDO:0006474

Definition

A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitional cell carcinoma

Professional guidelines

PubMed

Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer.
Helal C, Pobel C, Bayle A, Vasseur D, Nicotra C, Blanc-Durand F, Naoun N, Bernard-Tessier A, Patrikidou A, Colomba E, Flippot R, Fuerea A, Auger N, Ngo Camus M, Besse B, Lacroix L, Rouleau E, Ponce S, Italiano A, Loriot Y
Eur J Cancer 2023 Dec;195:113368. Epub 2023 Oct 6 doi: 10.1016/j.ejca.2023.113368. PMID: 37897866
ACR Appropriateness Criteria® Post-Treatment Surveillance of Bladder Cancer: 2021 Update.
Expert Panel on Urological Imaging, Allen BC, Oto A, Akin O, Alexander LF, Froemming AT, Fulgham PF, Halpern DJ, Gettle LM, Maranchie JK, Patel BN, Patlas MN, Schieda N, Solanki A, Turkbey IB, Venkatesan AM, Yoo DC, Lockhart ME
J Am Coll Radiol 2021 May;18(5S):S126-S138. doi: 10.1016/j.jacr.2021.02.011. PMID: 33958107
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG
J Clin Oncol 2001 Feb 1;19(3):666-75. doi: 10.1200/JCO.2001.19.3.666. PMID: 11157016

Recent clinical studies

Etiology

Surgical management for upper urinary tract transitional cell carcinoma.
Rai BP, Shelley M, Coles B, Biyani CS, El-Mokadem I, Nabi G
Cochrane Database Syst Rev 2011 Apr 13;(4):CD007349. doi: 10.1002/14651858.CD007349.pub2. PMID: 21491399
Familial and genetic risk of transitional cell carcinoma of the urinary tract.
Mueller CM, Caporaso N, Greene MH
Urol Oncol 2008 Sep-Oct;26(5):451-64. Epub 2008 Jun 18 doi: 10.1016/j.urolonc.2008.02.016. PMID: 18562223Free PMC Article
Canine transitional cell carcinoma.
Mutsaers AJ, Widmer WR, Knapp DW
J Vet Intern Med 2003 Mar-Apr;17(2):136-44. doi: 10.1892/0891-6640(2003)017<0136:ctcc>2.3.co;2. PMID: 12683611
Familial transitional cell carcinoma.
Kiemeney LA, Schoenberg M
J Urol 1996 Sep;156(3):867-72. PMID: 8709350
Transitional cell carcinoma of the bladder in the pediatric patient.
Hoenig DM, McRae S, Chen SC, Diamond DA, Rabinowitz R, Caldamone AA
J Urol 1996 Jul;156(1):203-5. PMID: 8648805

Diagnosis

Recent advances in diagnosis and treatment of transitional cell carcinoma of the bladder.
Martyn-Hemphill C, Mak D, Khan MS, Challacombe BJ, Bishop CV
Int J Surg 2013;11(9):749-52. Epub 2013 Sep 5 doi: 10.1016/j.ijsu.2013.08.018. PMID: 24013072
Imaging and staging of transitional cell carcinoma: part 2, upper urinary tract.
Vikram R, Sandler CM, Ng CS
AJR Am J Roentgenol 2009 Jun;192(6):1488-93. doi: 10.2214/AJR.09.2577. PMID: 19457809
Imaging and staging of transitional cell carcinoma: part 1, lower urinary tract.
Vikram R, Sandler CM, Ng CS
AJR Am J Roentgenol 2009 Jun;192(6):1481-7. doi: 10.2214/AJR.08.1318. PMID: 19457808
Canine transitional cell carcinoma.
Mutsaers AJ, Widmer WR, Knapp DW
J Vet Intern Med 2003 Mar-Apr;17(2):136-44. doi: 10.1892/0891-6640(2003)017<0136:ctcc>2.3.co;2. PMID: 12683611
Transitional cell carcinoma of the pelvicalices and ureter.
Leder RA, Dunnick NR
AJR Am J Roentgenol 1990 Oct;155(4):713-22. doi: 10.2214/ajr.155.4.2119098. PMID: 2119098

Therapy

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Perioperative pembrolizumab therapy in muscle-invasive bladder cancer: Phase III KEYNOTE-866 and KEYNOTE-905/EV-303.
Galsky MD, Hoimes CJ, Necchi A, Shore N, Witjes JA, Steinberg G, Bedke J, Nishiyama H, Fang X, Kataria R, Sbar E, Jia X, Siefker-Radtke A
Future Oncol 2021 Aug;17(24):3137-3150. Epub 2021 May 19 doi: 10.2217/fon-2021-0273. PMID: 34008425
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
Fibroblast growth factor receptor (FGFR) inhibitors: A review of a novel therapeutic class.
Weaver A, Bossaer JB
J Oncol Pharm Pract 2021 Apr;27(3):702-710. Epub 2020 Dec 29 doi: 10.1177/1078155220983425. PMID: 33375902
The biology and rationale of targeting nectin-4 in urothelial carcinoma.
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713

Prognosis

Urothelial cell carcinoma of the bladder in pediatric patients: a systematic review and data analysis of the world literature.
Rezaee ME, Dunaway CM, Baker ML, Penna FJ, Chavez DR
J Pediatr Urol 2019 Aug;15(4):309-314. Epub 2019 Jun 22 doi: 10.1016/j.jpurol.2019.06.013. PMID: 31326327
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD
Lancet Oncol 2017 Mar;18(3):312-322. Epub 2017 Jan 26 doi: 10.1016/S1470-2045(17)30065-7. PMID: 28131785
High-grade Ta urothelial carcinoma and carcinoma in situ of the bladder.
Sylvester RJ, van der Meijden A, Witjes JA, Jakse G, Nonomura N, Cheng C, Torres A, Watson R, Kurth KH
Urology 2005 Dec;66(6 Suppl 1):90-107. doi: 10.1016/j.urology.2005.06.135. PMID: 16399418
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG
J Clin Oncol 2001 Feb 1;19(3):666-75. doi: 10.1200/JCO.2001.19.3.666. PMID: 11157016
Transitional cell carcinoma of the bladder in the pediatric patient.
Hoenig DM, McRae S, Chen SC, Diamond DA, Rabinowitz R, Caldamone AA
J Urol 1996 Jul;156(1):203-5. PMID: 8648805

Clinical prediction guides

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.
Feng H, Deng Z, Huang Y, Liu Z, Ruan Y, Wang T, Liu J
Front Immunol 2023;14:1219209. Epub 2023 Aug 17 doi: 10.3389/fimmu.2023.1219209. PMID: 37662947Free PMC Article
Crosstalk between autophagy and bladder transitional cell carcinoma by autophagy-related lncRNAs.
Feng J, Wang M, Du GS, Peng K, Li LQ, Li XS
Medicine (Baltimore) 2023 Jun 30;102(26):e34130. doi: 10.1097/MD.0000000000034130. PMID: 37390250Free PMC Article
Urine cell-free microRNA as biomarkers for transitional cell carcinoma.
Geva GA, Gielchinsky I, Aviv N, Max KEA, Gofrit ON, Gur-Wahnon D, Ben-Dov IZ
BMC Res Notes 2017 Nov 29;10(1):641. doi: 10.1186/s13104-017-2950-9. PMID: 29187235Free PMC Article
The Emerging Molecular Landscape of Urothelial Carcinoma.
Solomon JP, Hansel DE
Surg Pathol Clin 2016 Sep;9(3):391-404. doi: 10.1016/j.path.2016.04.004. PMID: 27523968
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Recent systematic reviews

The evolving panorama of HER2-targeted treatments in metastatic urothelial cancer: A systematic review and future perspectives.
Patelli G, Zeppellini A, Spina F, Righetti E, Stabile S, Amatu A, Tosi F, Ghezzi S, Siena S, Sartore-Bianchi A
Cancer Treat Rev 2022 Mar;104:102351. Epub 2022 Jan 31 doi: 10.1016/j.ctrv.2022.102351. PMID: 35180563
The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review.
Bouleftour W, Guillot A, Magne N
Mol Cancer Ther 2022 Apr 1;21(4):493-501. doi: 10.1158/1535-7163.MCT-21-0846. PMID: 35131876
Systemic therapies for metastatic hormone-sensitive prostate cancer: network meta-analysis.
Mori K, Mostafaei H, Sari Motlagh R, Pradere B, Quhal F, Laukhtina E, Schuettfort VM, Kramer G, Abufaraj M, Karakiewicz PI, Kimura T, Egawa S, Shariat SF
BJU Int 2022 Apr;129(4):423-433. Epub 2021 Jul 21 doi: 10.1111/bju.15507. PMID: 34171173Free PMC Article
Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375

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