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Grade 4 Ileus, CTCAE

MedGen UID:
288078
•Concept ID:
C1560460
•
Finding
Synonym: CTCAE Grade 4 Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation)

Definition

Life-threatening consequences; urgent intervention indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Ileus, CTCAE

Professional guidelines

PubMed

Treatment of primary or recurrent non-resectable pancreatic cancer with proton beam irradiation combined with gemcitabine-based chemotherapy.
Lautenschlaeger S, Dumke C, Exeli L, Hauswald H, Engenhart-Cabillic R, Eberle F
Strahlenther Onkol 2023 Nov;199(11):982-991. Epub 2023 Jul 10 doi: 10.1007/s00066-023-02106-5. PMID: 37428207

Recent clinical studies

Etiology

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383

Therapy

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383
Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma: a feasibility study.
Nagao S, Iwasa N, Kurosaki A, Nishikawa T, Ohishi R, Hasegawa K, Goto T, Fujiwara K
Int J Gynecol Cancer 2012 Jan;22(1):70-5. doi: 10.1097/IGC.0b013e318234f927. PMID: 22146766

Prognosis

Treatment of primary or recurrent non-resectable pancreatic cancer with proton beam irradiation combined with gemcitabine-based chemotherapy.
Lautenschlaeger S, Dumke C, Exeli L, Hauswald H, Engenhart-Cabillic R, Eberle F
Strahlenther Onkol 2023 Nov;199(11):982-991. Epub 2023 Jul 10 doi: 10.1007/s00066-023-02106-5. PMID: 37428207
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR
Ann Oncol 2015 Oct;26(10):2141-9. Epub 2015 Jul 27 doi: 10.1093/annonc/mdv309. PMID: 26216383

Clinical prediction guides

Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma.
Bernard S, Hachon L, Diasonama JF, Madaoui C, Aguinaga L, Miekoutima E, Moatti H, Perrial E, Madelaine I, Brice P, Thieblemont C
Ann Hematol 2021 Apr;100(4):979-986. Epub 2021 Feb 19 doi: 10.1007/s00277-020-04341-7. PMID: 33608849Free PMC Article
Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma: a feasibility study.
Nagao S, Iwasa N, Kurosaki A, Nishikawa T, Ohishi R, Hasegawa K, Goto T, Fujiwara K
Int J Gynecol Cancer 2012 Jan;22(1):70-5. doi: 10.1097/IGC.0b013e318234f927. PMID: 22146766

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