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Grade 3 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

MedGen UID:
288097
•Concept ID:
C1560548
•
Finding
Synonym: CTCAE Grade 3 Large bowel mucositis/stomatitis (clinical exam)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

Professional guidelines

PubMed

Erudition from primary posterior sagittal anorectoplasty for anorectal malformations over two decades.
Sharma S
Pediatr Surg Int 2023 Oct 1;39(1):277. doi: 10.1007/s00383-023-05559-y. PMID: 37777986
Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease.
Kulkarni N, Jain P, Shindikar A, Suryawanshi P, Thorat N
Carbohydr Polym 2022 Jul 15;288:119351. Epub 2022 Mar 14 doi: 10.1016/j.carbpol.2022.119351. PMID: 35450623
Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation.
Brcic I, Dawson H, Gröchenig HP, Högenauer C, Kashofer K
Int J Surg Pathol 2021 Feb;29(1):46-53. Epub 2020 Oct 8 doi: 10.1177/1066896920963798. PMID: 33030071

Recent clinical studies

Etiology

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.
Rubbino F, Garlatti V, Garzarelli V, Massimino L, Spanò S, Iadarola P, Cagnone M, Giera M, Heijink M, Guglielmetti S, Arena V, Malesci A, Laghi L, Danese S, Vetrano S
Sci Rep 2022 Jan 10;12(1):381. doi: 10.1038/s41598-021-03787-7. PMID: 35013389Free PMC Article
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.
Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N
World J Gastroenterol 2015 May 7;21(17):5149-57. doi: 10.3748/wjg.v21.i17.5149. PMID: 25954088Free PMC Article

Diagnosis

Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.
Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N
World J Gastroenterol 2015 May 7;21(17):5149-57. doi: 10.3748/wjg.v21.i17.5149. PMID: 25954088Free PMC Article

Therapy

Mucosal inflammation predicts response to systemic steroids in immune checkpoint inhibitor colitis.
Mooradian MJ, Wang DY, Coromilas A, Lumish M, Chen T, Giobbie-Hurder A, Johnson DB, Sullivan RJ, Dougan M
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2019-000451. PMID: 32414860Free PMC Article
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
A Phase I Trial of Berberine in Chinese with Ulcerative Colitis.
Xu L, Zhang Y, Xue X, Liu J, Li ZS, Yang GY, Song Y, Pan Y, Ma Y, Hu S, Wen A, Jia Y, Rodriguez LM, Tull MB, Benante K, Khan SA, Cao Y, Jovanovic B, Richmond E, Umar A, Bergan R, Wu K
Cancer Prev Res (Phila) 2020 Jan;13(1):117-126. Epub 2019 Oct 16 doi: 10.1158/1940-6207.CAPR-19-0258. PMID: 31619442
Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis.
Klepp P, Tollisen A, Røseth A, Cvancarova Småstuen M, Andersen SN, Vatn M, Moum BA, Brackmann S
World J Gastroenterol 2018 Sep 21;24(35):4069-4076. doi: 10.3748/wjg.v24.i35.4069. PMID: 30254411Free PMC Article
Infection, inflammation, and the irritable bowel syndrome.
Spiller R, Garsed K
Dig Liver Dis 2009 Dec;41(12):844-9. Epub 2009 Aug 28 doi: 10.1016/j.dld.2009.07.007. PMID: 19716778

Prognosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Neuroendocrine Cells Are Commonly Absent in the Intestinal Crypts in Autoimmune Enteropathy.
Lee HE, Yuan L, Wu TT
Am J Surg Pathol 2020 Aug;44(8):1130-1136. doi: 10.1097/PAS.0000000000001516. PMID: 32590456
Mucosal inflammation predicts response to systemic steroids in immune checkpoint inhibitor colitis.
Mooradian MJ, Wang DY, Coromilas A, Lumish M, Chen T, Giobbie-Hurder A, Johnson DB, Sullivan RJ, Dougan M
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2019-000451. PMID: 32414860Free PMC Article
Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.
Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N
World J Gastroenterol 2015 May 7;21(17):5149-57. doi: 10.3748/wjg.v21.i17.5149. PMID: 25954088Free PMC Article
Infection, inflammation, and the irritable bowel syndrome.
Spiller R, Garsed K
Dig Liver Dis 2009 Dec;41(12):844-9. Epub 2009 Aug 28 doi: 10.1016/j.dld.2009.07.007. PMID: 19716778

Clinical prediction guides

GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.
Rubbino F, Garlatti V, Garzarelli V, Massimino L, Spanò S, Iadarola P, Cagnone M, Giera M, Heijink M, Guglielmetti S, Arena V, Malesci A, Laghi L, Danese S, Vetrano S
Sci Rep 2022 Jan 10;12(1):381. doi: 10.1038/s41598-021-03787-7. PMID: 35013389Free PMC Article
Prediction of technically difficult endoscopic submucosal dissection for large superficial colorectal tumors: a novel clinical score model.
Li B, Shi Q, Xu EP, Yao LQ, Cai SL, Qi ZP, Sun D, He DL, Yalikong A, Lv ZT, Zhou PH, Zhong YS
Gastrointest Endosc 2021 Jul;94(1):133-144.e3. Epub 2020 Nov 19 doi: 10.1016/j.gie.2020.11.012. PMID: 33221323
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
Development and validation of the Nancy histological index for UC.
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold MD, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L
Gut 2017 Jan;66(1):43-49. Epub 2015 Oct 13 doi: 10.1136/gutjnl-2015-310187. PMID: 26464414
Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.
Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N
World J Gastroenterol 2015 May 7;21(17):5149-57. doi: 10.3748/wjg.v21.i17.5149. PMID: 25954088Free PMC Article

Recent systematic reviews

Systematic review with meta-analysis: IBD-associated colonic dysplasia prognosis in the videoendoscopic era (1990 to present).
Kabir M, Fofaria R, Arebi N, Bassett P, Tozer PJ, Hart AL, Thomas-Gibson S, Humphries A, Suzuki N, Saunders B, Warusavitarne J, Faiz O, Wilson A
Aliment Pharmacol Ther 2020 Jul;52(1):5-19. Epub 2020 May 20 doi: 10.1111/apt.15778. PMID: 32432797

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