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Grade 1 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

MedGen UID:
288100
•Concept ID:
C1560558
•
Finding
Synonym: CTCAE Grade 1 Oral cavity mucositis/stomatitis (clinical exam)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

Professional guidelines

PubMed

Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers.
Bergamaschi L, Vincini MG, Zaffaroni M, Pepa M, Angelicone I, Astone A, Bergamini C, Buonopane S, Conte M, De Rosa N, Deantoni C, Dell'Oca I, Di Gennaro D, Di Muzio N, Osti MF, Federico M, Ferini G, Franzese C, Gatti M, Grillo A, Iorio V, Manzo R, Marmiroli L, Martin G, Mazzuca F, Molinaro MA, Muto M, Pacelli R, Pepe A, Perillo A, Russo D, Salerno F, Spadaro P, Viola A, Iorio GC, Muto P, Ricardi U, Alterio D
Support Care Cancer 2023 Dec 19;32(1):38. doi: 10.1007/s00520-023-08185-5. PMID: 38110572Free PMC Article
Effectiveness of mouthrinses in prevention and treatment of radiation induced mucositis: A systematic review.
Manoharan V, Fareed N, Battur H, Khanagar S, Praveena J
J Cancer Res Ther 2020 Dec;16(Supplement):S1-S10. doi: 10.4103/jcrt.JCRT_176_18. PMID: 33380645
Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with cancer.
Pires Marques EC, Piccolo Lopes F, Nascimento IC, Morelli J, Pereira MV, Machado Meiken VM, Pinheiro SL
Photodiagnosis Photodyn Ther 2020 Mar;29:101621. Epub 2019 Dec 10 doi: 10.1016/j.pdpdt.2019.101621. PMID: 31841687

Recent clinical studies

Etiology

Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article

Diagnosis

Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges.
Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK
Periodontol 2000 2019 Jun;80(1):126-147. doi: 10.1111/prd.12259. PMID: 31090138
Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
Müller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):591-602. Epub 2018 Mar 1 doi: 10.1016/j.oooo.2018.02.012. PMID: 29606637
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article
Oral graft-versus-host disease.
Schubert MM, Correa ME
Dent Clin North Am 2008 Jan;52(1):79-109, viii-ix. doi: 10.1016/j.cden.2007.10.004. PMID: 18154866

Therapy

Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102.
Kornblum N, Zhao F, Manola J, Klein P, Ramaswamy B, Brufsky A, Stella PJ, Burnette B, Telli M, Makower DF, Cheema P, Truica CI, Wolff AC, Soori GS, Haley B, Wassenaar TR, Goldstein LJ, Miller KD, Sparano JA
J Clin Oncol 2018 Jun 1;36(16):1556-1563. Epub 2018 Apr 17 doi: 10.1200/JCO.2017.76.9331. PMID: 29664714Free PMC Article
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article

Prognosis

Commensal oral microbiota impacts ulcerative oral mucositis clinical course in allogeneic stem cell transplant recipients.
Bruno JS, Heidrich V, Knebel FH, de Molla VC, Parahyba CJ, Miranda-Silva W, Asprino PF, Tucunduva L, Rocha V, Novis Y, Arrais-Rodrigues C, Camargo AA, Fregnani ER
Sci Rep 2022 Oct 20;12(1):17527. doi: 10.1038/s41598-022-21775-3. PMID: 36266464Free PMC Article
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges.
Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK
Periodontol 2000 2019 Jun;80(1):126-147. doi: 10.1111/prd.12259. PMID: 31090138
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102.
Kornblum N, Zhao F, Manola J, Klein P, Ramaswamy B, Brufsky A, Stella PJ, Burnette B, Telli M, Makower DF, Cheema P, Truica CI, Wolff AC, Soori GS, Haley B, Wassenaar TR, Goldstein LJ, Miller KD, Sparano JA
J Clin Oncol 2018 Jun 1;36(16):1556-1563. Epub 2018 Apr 17 doi: 10.1200/JCO.2017.76.9331. PMID: 29664714Free PMC Article

Clinical prediction guides

Commensal oral microbiota impacts ulcerative oral mucositis clinical course in allogeneic stem cell transplant recipients.
Bruno JS, Heidrich V, Knebel FH, de Molla VC, Parahyba CJ, Miranda-Silva W, Asprino PF, Tucunduva L, Rocha V, Novis Y, Arrais-Rodrigues C, Camargo AA, Fregnani ER
Sci Rep 2022 Oct 20;12(1):17527. doi: 10.1038/s41598-022-21775-3. PMID: 36266464Free PMC Article
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors.
Ferenczi Ö, Major T, Akiyama H, Fröhlich G, Oberna F, Révész M, Poósz M, Polgár C, Takácsi-Nagy Z
Brachytherapy 2021 Mar-Apr;20(2):376-382. Epub 2020 Nov 26 doi: 10.1016/j.brachy.2020.10.008. PMID: 33250304
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article

Recent systematic reviews

Interventions for managing oral submucous fibrosis.
Jones A, Veale B, Li T, Aggarwal VR, Twigg J
Cochrane Database Syst Rev 2024 Feb 28;2(2):CD007156. doi: 10.1002/14651858.CD007156.pub3. PMID: 38415846Free PMC Article
Duration of canine retraction with fixed appliances: A systematic review and meta-analysis.
Wazwaz F, Seehra J, Carpenter GH, Papageorgiou SN, Cobourne MT
Am J Orthod Dentofacial Orthop 2023 Feb;163(2):154-172. Epub 2022 Dec 1 doi: 10.1016/j.ajodo.2022.08.009. PMID: 36464569
Oral Manifestations in Patients with COVID-19: A Living Systematic Review.
Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, Santos-Silva AR, Guerra ENS
J Dent Res 2021 Feb;100(2):141-154. Epub 2020 Sep 11 doi: 10.1177/0022034520957289. PMID: 32914677
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article

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