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Grade 4 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

MedGen UID:
288101
•Concept ID:
C1560561
•
Finding
Synonym: CTCAE Grade 4 Oral cavity mucositis/stomatitis (clinical exam)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

Professional guidelines

PubMed

Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.
Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, Kebschull M, Papapanou PN, Tonetti MS, Sanz M; EFP workshop participants and methodological consultant
J Clin Periodontol 2023 Jun;50 Suppl 26:4-76. Epub 2023 Jun 4 doi: 10.1111/jcpe.13823. PMID: 37271498
Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with cancer.
Pires Marques EC, Piccolo Lopes F, Nascimento IC, Morelli J, Pereira MV, Machado Meiken VM, Pinheiro SL
Photodiagnosis Photodyn Ther 2020 Mar;29:101621. Epub 2019 Dec 10 doi: 10.1016/j.pdpdt.2019.101621. PMID: 31841687
Oral Glutamine in Preventing Treatment-Related Mucositis in Adult Patients With Cancer: A Systematic Review.
Sayles C, Hickerson SC, Bhat RR, Hall J, Garey KW, Trivedi MV
Nutr Clin Pract 2016 Apr;31(2):171-9. Epub 2015 Oct 27 doi: 10.1177/0884533615611857. PMID: 26507188

Recent clinical studies

Etiology

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article

Diagnosis

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Prognostic markers of lymphoma development in primary Sjögren syndrome.
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206
The Incidence and Severity of Oral Mucositis among Allogeneic Hematopoietic Stem Cell Transplantation Patients: A Systematic Review.
Chaudhry HM, Bruce AJ, Wolf RC, Litzow MR, Hogan WJ, Patnaik MS, Kremers WK, Phillips GL, Hashmi SK
Biol Blood Marrow Transplant 2016 Apr;22(4):605-616. Epub 2015 Sep 26 doi: 10.1016/j.bbmt.2015.09.014. PMID: 26409924

Therapy

Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.
Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, Kebschull M, Papapanou PN, Tonetti MS, Sanz M; EFP workshop participants and methodological consultant
J Clin Periodontol 2023 Jun;50 Suppl 26:4-76. Epub 2023 Jun 4 doi: 10.1111/jcpe.13823. PMID: 37271498
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102.
Kornblum N, Zhao F, Manola J, Klein P, Ramaswamy B, Brufsky A, Stella PJ, Burnette B, Telli M, Makower DF, Cheema P, Truica CI, Wolff AC, Soori GS, Haley B, Wassenaar TR, Goldstein LJ, Miller KD, Sparano JA
J Clin Oncol 2018 Jun 1;36(16):1556-1563. Epub 2018 Apr 17 doi: 10.1200/JCO.2017.76.9331. PMID: 29664714Free PMC Article

Prognosis

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer.
Anderson CM, Lee CM, Saunders DP, Curtis A, Dunlap N, Nangia C, Lee AS, Gordon SM, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain AK, Wheeler J, Blakaj D, Bonomi M, Agarwala SS, Garg M, Worden F, Holmlund J, Brill JM, Downs M, Sonis ST, Katz S, Buatti JM
J Clin Oncol 2019 Dec 1;37(34):3256-3265. Epub 2019 Oct 16 doi: 10.1200/JCO.19.01507. PMID: 31618127Free PMC Article
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102.
Kornblum N, Zhao F, Manola J, Klein P, Ramaswamy B, Brufsky A, Stella PJ, Burnette B, Telli M, Makower DF, Cheema P, Truica CI, Wolff AC, Soori GS, Haley B, Wassenaar TR, Goldstein LJ, Miller KD, Sparano JA
J Clin Oncol 2018 Jun 1;36(16):1556-1563. Epub 2018 Apr 17 doi: 10.1200/JCO.2017.76.9331. PMID: 29664714Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206

Clinical prediction guides

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors.
Ferenczi Ö, Major T, Akiyama H, Fröhlich G, Oberna F, Révész M, Poósz M, Polgár C, Takácsi-Nagy Z
Brachytherapy 2021 Mar-Apr;20(2):376-382. Epub 2020 Nov 26 doi: 10.1016/j.brachy.2020.10.008. PMID: 33250304
Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.
Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E
Radiat Oncol 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2. PMID: 31118057Free PMC Article
Otorhinolaryngological Toxicities of New Drugs in Oncology.
Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC
Adv Ther 2017 Apr;34(4):866-894. Epub 2017 Mar 17 doi: 10.1007/s12325-017-0512-0. PMID: 28315206

Recent systematic reviews

Prevalence of oral mucosal lesions in patients with pemphigus vulgaris: A systematic review and meta-analysis.
Batistella EÂ, Sabino da Silva R, Rivero ERC, Silva CAB
J Oral Pathol Med 2021 Sep;50(8):750-757. Epub 2021 Apr 15 doi: 10.1111/jop.13167. PMID: 33713362
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta-analysis.
Bett JVS, Batistella EÂ, Melo G, Munhoz EA, Silva CAB, Guerra ENDS, Porporatti AL, De Luca Canto G
J Oral Pathol Med 2019 Apr;48(4):270-277. Epub 2019 Feb 12 doi: 10.1111/jop.12831. PMID: 30673134
Oral Glutamine in Preventing Treatment-Related Mucositis in Adult Patients With Cancer: A Systematic Review.
Sayles C, Hickerson SC, Bhat RR, Hall J, Garey KW, Trivedi MV
Nutr Clin Pract 2016 Apr;31(2):171-9. Epub 2015 Oct 27 doi: 10.1177/0884533615611857. PMID: 26507188
The Incidence and Severity of Oral Mucositis among Allogeneic Hematopoietic Stem Cell Transplantation Patients: A Systematic Review.
Chaudhry HM, Bruce AJ, Wolf RC, Litzow MR, Hogan WJ, Patnaik MS, Kremers WK, Phillips GL, Hashmi SK
Biol Blood Marrow Transplant 2016 Apr;22(4):605-616. Epub 2015 Sep 26 doi: 10.1016/j.bbmt.2015.09.014. PMID: 26409924

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