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Multifocal choroiditis

MedGen UID:
288551
Concept ID:
C1533060
Disease or Syndrome
Synonyms: Choroiditis, Multifocal; Multifocal Choroiditis
SNOMED CT: Multifocal choroiditis (414783007); MFC-multifocal choroiditis (414783007)
 
Monarch Initiative: MONDO:0023833

Definition

Multifocal choroiditis (MFC) is an inflammatory disorder characterized by swelling of the eye (called uveitis) and multiple lesions in the choroid, a layer of blood vessels between the white of the eye and the retina. Symptoms include blurry vision, floaters, sensitivity to light, blind spots and mild eye discomfort. Though the cause is unknown, multifocal choroiditis is seen most frequently in women ages 20 to 60, and usually affects both eyes. MFC is generally treated with steroid medication that can be taken orally or injected into the eye. Multifocal choroiditis is a chronic condition, thus symptoms may return or worsen even after successful treatment. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal choroiditis

Professional guidelines

PubMed

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:152-158. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.043. PMID: 33845016Free PMC Article
Gargouri S, Kaibi I, Zone I, Khairallah M, Koubaa M, Ben Jemaa M, Feki J
Tunis Med 2019 Jan;97(1):106-112. PMID: 31535701

Recent clinical studies

Etiology

Cicinelli MV, Ramtohul P, Marchese A, Bandello F, Bailey Freund K, Miserocchi E, Jampol LM
Prog Retin Eye Res 2023 Nov;97:101207. Epub 2023 Aug 12 doi: 10.1016/j.preteyeres.2023.101207. PMID: 37574123
Ramtohul P, Cicinelli MV, Dolz-Marco R, Gal-Or O, Mrejen S, García-Martínez JR, Goldberg A, Cunha de Souza E, Miserocchi E, Cunningham ET Jr, Yannuzzi LA, Freund KB, Tsui E
Retina 2023 Aug 1;43(8):1377-1385. doi: 10.1097/IAE.0000000000003815. PMID: 37071923Free PMC Article
Chen C, Cheng Y, Zhang Z, Zhang Y, Xiao Y, Peng X
Retina 2022 Nov 1;42(11):2110-2119. doi: 10.1097/IAE.0000000000003569. PMID: 35839489
de Groot EL, van Huet RAC, Bloemenkamp KWM, de Boer JH, Ossewaarde-van Norel J
Acta Ophthalmol 2022 Feb;100(1):82-88. Epub 2021 May 19 doi: 10.1111/aos.14898. PMID: 34009733Free PMC Article
Ahnood D, Madhusudhan S, Tsaloumas MD, Waheed NK, Keane PA, Denniston AK
Surv Ophthalmol 2017 Mar-Apr;62(2):113-126. Epub 2016 Oct 15 doi: 10.1016/j.survophthal.2016.10.003. PMID: 27751823

Diagnosis

Cicinelli MV, Ramtohul P, Marchese A, Bandello F, Bailey Freund K, Miserocchi E, Jampol LM
Prog Retin Eye Res 2023 Nov;97:101207. Epub 2023 Aug 12 doi: 10.1016/j.preteyeres.2023.101207. PMID: 37574123
Dutta Majumder P, Biswas J, Gupta A
Indian J Ophthalmol 2019 Mar;67(3):325-333. doi: 10.4103/ijo.IJO_822_18. PMID: 30777946Free PMC Article
Salah S, Abad S, Monnet D, Brézin AP
J Fr Ophtalmol 2018 Dec;41(10):e451-e467. Epub 2018 Nov 16 doi: 10.1016/j.jfo.2018.10.002. PMID: 30449643
Nazari Khanamiri H, Rao NA
Surv Ophthalmol 2013 May-Jun;58(3):203-32. Epub 2013 Mar 27 doi: 10.1016/j.survophthal.2012.08.008. PMID: 23541041Free PMC Article
Verougstraete C
Bull Soc Belge Ophtalmol 2001;(279):67-78. PMID: 11344717

Therapy

Belmonte Grau M, Acebes García M, Jacobo González Guijarro J
Eur J Ophthalmol 2023 Jan;33(1):NP15-NP18. Epub 2021 Aug 21 doi: 10.1177/11206721211039938. PMID: 34420419
Shmueli O, Amer R
Graefes Arch Clin Exp Ophthalmol 2022 Jun;260(6):2013-2021. Epub 2022 Jan 4 doi: 10.1007/s00417-021-05539-9. PMID: 34982218
de Groot EL, van Huet RAC, Bloemenkamp KWM, de Boer JH, Ossewaarde-van Norel J
Acta Ophthalmol 2022 Feb;100(1):82-88. Epub 2021 May 19 doi: 10.1111/aos.14898. PMID: 34009733Free PMC Article
Orellana Rios J, Verdaguer Díaz JI, Agee J, Theodore Smith R
Arch Soc Esp Oftalmol (Engl Ed) 2018 Apr;93(4):193-197. Epub 2017 Aug 24 doi: 10.1016/j.oftal.2017.07.002. PMID: 28844569
Nazari Khanamiri H, Rao NA
Surv Ophthalmol 2013 May-Jun;58(3):203-32. Epub 2013 Mar 27 doi: 10.1016/j.survophthal.2012.08.008. PMID: 23541041Free PMC Article

Prognosis

de Groot EL, van Huet RAC, Bloemenkamp KWM, de Boer JH, Ossewaarde-van Norel J
Acta Ophthalmol 2022 Feb;100(1):82-88. Epub 2021 May 19 doi: 10.1111/aos.14898. PMID: 34009733Free PMC Article
Suresh S, Tsui E
Curr Opin Ophthalmol 2020 Nov;31(6):532-537. doi: 10.1097/ICU.0000000000000705. PMID: 33009086
Ahnood D, Madhusudhan S, Tsaloumas MD, Waheed NK, Keane PA, Denniston AK
Surv Ophthalmol 2017 Mar-Apr;62(2):113-126. Epub 2016 Oct 15 doi: 10.1016/j.survophthal.2016.10.003. PMID: 27751823
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832
Quillen DA, Davis JB, Gottlieb JL, Blodi BA, Callanan DG, Chang TS, Equi RA
Am J Ophthalmol 2004 Mar;137(3):538-50. doi: 10.1016/j.ajo.2004.01.053. PMID: 15013878

Clinical prediction guides

Ramtohul P, Cicinelli MV, Dolz-Marco R, Gal-Or O, Mrejen S, García-Martínez JR, Goldberg A, Cunha de Souza E, Miserocchi E, Cunningham ET Jr, Yannuzzi LA, Freund KB, Tsui E
Retina 2023 Aug 1;43(8):1377-1385. doi: 10.1097/IAE.0000000000003815. PMID: 37071923Free PMC Article
Moussa K, Alsberge JB, Munk MR, Vora RA, Emami-Naeini P, Yiu G, Cunningham ET Jr
Retina 2022 Aug 1;42(8):1574-1582. doi: 10.1097/IAE.0000000000003481. PMID: 35333832
Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Gilbert RM, Niederer RL, Kramer M, Sharief L, Sharon Y, Bar A, Lightman S, Tomkins-Netzer O
Am J Ophthalmol 2020 May;213:244-251. Epub 2020 Feb 4 doi: 10.1016/j.ajo.2020.01.031. PMID: 32027868
Ahnood D, Madhusudhan S, Tsaloumas MD, Waheed NK, Keane PA, Denniston AK
Surv Ophthalmol 2017 Mar-Apr;62(2):113-126. Epub 2016 Oct 15 doi: 10.1016/j.survophthal.2016.10.003. PMID: 27751823

Recent systematic reviews

Bennett N, John L, Likhar N, Agrawal R, Amoaku WM
Adv Ther 2018 May;35(5):591-603. Epub 2018 Apr 23 doi: 10.1007/s12325-018-0698-9. PMID: 29687336
Barisani-Asenbauer T, Maca SM, Mejdoubi L, Emminger W, Machold K, Auer H
Orphanet J Rare Dis 2012 Aug 29;7:57. doi: 10.1186/1750-1172-7-57. PMID: 22932001Free PMC Article

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