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Protein Carbonylation

MedGen UID:: 288790
•Concept ID:: C1563721
•: Molecular Function

Synonyms:

Carbonyl Formation, Protein; Carbonylated Protein Formation; Carbonylation, Protein; Carbonylations, Protein; Protein Carbonyl Formation; Protein Carbonylations

Definition

The appearance of carbonyl groups (such as aldehyde or ketone groups) in PROTEINS as the result of several oxidative modification reactions. It is a standard marker for OXIDATIVE STRESS. Carbonylated proteins tend to be more hydrophobic and resistant to proteolysis. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVProtein Carbonylation

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Cell Stress Process
    - Cellular Stress
      - Oxidative Stress
        Protein Carbonylation

Professional guidelines

PubMed

Occupational risk assessment of organophosphates with an emphasis on psychological and oxidative stress factors.

Fghihi-Zarandi A, Dabaghzadeh F, Vaziri A, Karami-Mohajeri S, Ghorbaninejad B, Zamani A, Rahimi-Sadegh K
Toxicol Ind Health 2022 Jun;38(6):342-350. Epub 2022 May 5 doi: 10.1177/07482337221096315. PMID: 35513771

The exogenous surfactant pre-treatment attenuates ventilator-induced lung injury in adult rats.

Chirico RN, de Matos NA, Castro TF, Cândido LDS, Miranda AG, Costa GP, Talvani A, Cangussú SD, Brochard L, Bezerra FS
Respir Physiol Neurobiol 2022 Aug;302:103911. Epub 2022 Apr 14 doi: 10.1016/j.resp.2022.103911. PMID: 35430285

New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.

Babizhayev MA
Am J Ther 2010 Jul-Aug;17(4):373-89. doi: 10.1097/MJT.0b013e3181d6b6c3. PMID: 20463577

See all (7)

Recent clinical studies

Etiology

Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches.

Akagawa M
Free Radic Res 2021 Apr;55(4):307-320. Epub 2021 Sep 1 doi: 10.1080/10715762.2020.1851027. PMID: 33183115

Analysis of Protein Oxidation in Food and Feed Products.

Hellwig M
J Agric Food Chem 2020 Nov 18;68(46):12870-12885. Epub 2020 Apr 13 doi: 10.1021/acs.jafc.0c00711. PMID: 32237708

Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial.

Silva LAD, Tortelli L, Motta J, Menguer L, Mariano S, Tasca G, Silveira GB, Pinho RA, Silveira PCL
Clinics (Sao Paulo) 2019;74:e322. Epub 2019 Jun 27 doi: 10.6061/clinics/2019/e322. PMID: 31271585 Free PMC Article

Role of protein carbonylation in diabetes.

Hecker M, Wagner AH
J Inherit Metab Dis 2018 Jan;41(1):29-38. Epub 2017 Nov 6 doi: 10.1007/s10545-017-0104-9. PMID: 29110177

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.

Vistoli G, De Maddis D, Cipak A, Zarkovic N, Carini M, Aldini G
Free Radic Res 2013 Aug;47 Suppl 1:3-27. doi: 10.3109/10715762.2013.815348. PMID: 23767955

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Diagnosis

Current Probes for Imaging Carbonylation in Cellular Systems and Their Relevance to Progression of Diseases.

Dilek O
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221137303. doi: 10.1177/15330338221137303. PMID: 36345252 Free PMC Article

Role of protein carbonylation in diabetes.

Hecker M, Wagner AH
J Inherit Metab Dis 2018 Jan;41(1):29-38. Epub 2017 Nov 6 doi: 10.1007/s10545-017-0104-9. PMID: 29110177

Oxidative stress and lipotoxicity.

Hauck AK, Bernlohr DA
J Lipid Res 2016 Nov;57(11):1976-1986. Epub 2016 Mar 23 doi: 10.1194/jlr.R066597. PMID: 27009116 Free PMC Article

Clinical Relevance of Biomarkers of Oxidative Stress.

Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, Gasparovic AC, Cuadrado A, Weber D, Poulsen HE, Grune T, Schmidt HH, Ghezzi P
Antioxid Redox Signal 2015 Nov 10;23(14):1144-70. Epub 2015 Oct 26 doi: 10.1089/ars.2015.6317. PMID: 26415143 Free PMC Article

Protein carbonylation: proteomics, specificity and relevance to aging.

Cabiscol E, Tamarit J, Ros J
Mass Spectrom Rev 2014 Jan-Feb;33(1):21-48. Epub 2013 Sep 30 doi: 10.1002/mas.21375. PMID: 24114980

See all (248)

Therapy

Effect of whey vs. soy protein supplementation on recovery kinetics following speed endurance training in competitive male soccer players: a randomized controlled trial.

Kritikos S, Papanikolaou K, Draganidis D, Poulios A, Georgakouli K, Tsimeas P, Tzatzakis T, Batsilas D, Batrakoulis A, Deli CK, Chatzinikolaou A, Mohr M, Jamurtas AZ, Fatouros IG
J Int Soc Sports Nutr 2021 Mar 16;18(1):23. doi: 10.1186/s12970-021-00420-w. PMID: 33726784 Free PMC Article

Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial.

Role of protein carbonylation in diabetes.

Hecker M, Wagner AH
J Inherit Metab Dis 2018 Jan;41(1):29-38. Epub 2017 Nov 6 doi: 10.1007/s10545-017-0104-9. PMID: 29110177

Protein Carbonylation in Human Smokers and Mammalian Models of Exposure to Cigarette Smoke: Focus on Redox Proteomic Studies.

Dalle-Donne I, Colombo G, Gornati R, Garavaglia ML, Portinaro N, Giustarini D, Bernardini G, Rossi R, Milzani A
Antioxid Redox Signal 2017 Mar 10;26(8):406-426. Epub 2016 Aug 8 doi: 10.1089/ars.2016.6772. PMID: 27393565

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease.

Paradies G, Paradies V, Ruggiero FM, Petrosillo G
World J Gastroenterol 2014 Oct 21;20(39):14205-18. doi: 10.3748/wjg.v20.i39.14205. PMID: 25339807 Free PMC Article

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Prognosis

A novel two-way rebalancing strategy for identifying carbonylation sites.

Chen L, Jing XY, Hao Y, Liu W, Zhu X, Han W
BMC Bioinformatics 2023 Nov 13;24(1):429. doi: 10.1186/s12859-023-05551-2. PMID: 37957582 Free PMC Article

Elevated Levels of Protein Carbonylation in Patients With Diabetic Nephropathy: Therapeutic and Diagnostic Prospects.

Almogbel E, Rasheed N
Am J Med Sci 2019 Jul;358(1):26-32. Epub 2019 Apr 4 doi: 10.1016/j.amjms.2019.03.011. PMID: 31076070

Ecobiological approach to research regarding ageing and diseases.

Radman M
Eur J Dermatol 2019 Apr 1;29(S1):11-14. doi: 10.1684/ejd.2019.3534. PMID: 31017576

Protein carbamylation and cardiovascular disease.

Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545 Free PMC Article

Mass-spectrometry-based characterization of oxidations in proteins.

Artemenko K, Mi J, Bergquist J
Free Radic Res 2015 May;49(5):477-93. Epub 2015 Apr 17 doi: 10.3109/10715762.2015.1023795. PMID: 25884782

See all (135)

Clinical prediction guides

Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial.

Oxidative Modifications in Tissue Pathology and Autoimmune Disease.

Yang ML, Doyle HA, Clarke SG, Herold KC, Mamula MJ
Antioxid Redox Signal 2018 Nov 10;29(14):1415-1431. Epub 2017 Dec 11 doi: 10.1089/ars.2017.7382. PMID: 29088923 Free PMC Article

Increased Risk of Atherosclerosis in Patients with Sarcoidosis.

Bargagli E, Rosi E, Pistolesi M, Lavorini F, Voltolini L, Rottoli P
Pathobiology 2017;84(5):258-263. Epub 2017 Aug 10 doi: 10.1159/000477736. PMID: 28793282

Protein carbamylation and cardiovascular disease.

Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545 Free PMC Article

Mass-spectrometry-based characterization of oxidations in proteins.

Artemenko K, Mi J, Bergquist J
Free Radic Res 2015 May;49(5):477-93. Epub 2015 Apr 17 doi: 10.3109/10715762.2015.1023795. PMID: 25884782

See all (490)

Recent systematic reviews

Carnosine and advanced glycation end products: a systematic review.

Ghodsi R, Kheirouri S
Amino Acids 2018 Sep;50(9):1177-1186. Epub 2018 Jun 1 doi: 10.1007/s00726-018-2592-9. PMID: 29858687

Oxidative stress and frailty: A systematic review and synthesis of the best evidence.

Soysal P, Isik AT, Carvalho AF, Fernandes BS, Solmi M, Schofield P, Veronese N, Stubbs B
Maturitas 2017 May;99:66-72. Epub 2017 Jan 16 doi: 10.1016/j.maturitas.2017.01.006. PMID: 28364871

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review.

Zinellu E, Zinellu A, Fois AG, Carru C, Pirina P
Respir Res 2016 Nov 14;17(1):150. doi: 10.1186/s12931-016-0471-z. PMID: 27842552 Free PMC Article

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.

Poulianiti KP, Kaltsatou A, Mitrou GI, Jamurtas AZ, Koutedakis Y, Maridaki M, Stefanidis I, Sakkas GK, Karatzaferi C
Oxid Med Cell Longev 2016;2016:8598253. Epub 2016 Aug 3 doi: 10.1155/2016/8598253. PMID: 27563376 Free PMC Article

Clinical and research markers of oxidative stress in chronic kidney disease.

Tucker PS, Dalbo VJ, Han T, Kingsley MI
Biomarkers 2013 Mar;18(2):103-15. Epub 2013 Jan 23 doi: 10.3109/1354750X.2012.749302. PMID: 23339563

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Protein Carbonylation

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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