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Y-linked disease

MedGen UID:
289655
•Concept ID:
C1563751
•
Disease or Syndrome
Synonyms: Disease, Y-Linked Genetic; Diseases, Y-Linked Genetic; Genetic Disease, Y-Linked; Genetic Diseases, Y Chromosome Linked; Genetic Diseases, Y Linked; Genetic Diseases, Y-Chromosome Linked; Genetic Diseases, Y-Linked; Y Linked Genetic Diseases; Y-Linked Genetic Disease; Y-Linked Genetic Diseases
 
Monarch Initiative: MONDO:0000428

Definition

Y-linked form of disease. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVY-linked disease

Professional guidelines

PubMed

Zevalin(®) (ibritumomab tiuxetan): After more than a decade of treatment experience, what have we learned?
Rizzieri D
Crit Rev Oncol Hematol 2016 Sep;105:5-17. Epub 2016 Jul 16 doi: 10.1016/j.critrevonc.2016.07.008. PMID: 27497027

Recent clinical studies

Etiology

Sex-linked genetic mechanisms and atrial fibrillation risk.
Wren G, Davies W
Eur J Med Genet 2022 Apr;65(4):104459. Epub 2022 Feb 19 doi: 10.1016/j.ejmg.2022.104459. PMID: 35189376
The Y chromosome: a blueprint for men's health?
Maan AA, Eales J, Akbarov A, Rowland J, Xu X, Jobling MA, Charchar FJ, Tomaszewski M
Eur J Hum Genet 2017 Nov;25(11):1181-1188. Epub 2017 Aug 30 doi: 10.1038/ejhg.2017.128. PMID: 28853720Free PMC Article
Roles of the Y chromosome genes in human cancers.
Kido T, Lau YF
Asian J Androl 2015 May-Jun;17(3):373-80. doi: 10.4103/1008-682X.150842. PMID: 25814157Free PMC Article
X chromosome and ovarian failure.
Toniolo D, Rizzolio F
Semin Reprod Med 2007 Jul;25(4):264-71. doi: 10.1055/s-2007-980220. PMID: 17594607
Y chromosome polymorphisms in medicine.
Krausz C, Quintana-Murci L, Forti G
Ann Med 2004;36(8):573-83. doi: 10.1080/07853890410018853. PMID: 15768829

Diagnosis

Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia.
Hoffman GE, Ma Y, Montgomery KS, Bendl J, Jaiswal MK, Kozlenkov A, Peters MA, Dracheva S, Fullard JF, Chess A, Devlin B, Sieberts SK, Roussos P
Biol Psychiatry 2022 Jan 1;91(1):92-101. Epub 2021 Mar 25 doi: 10.1016/j.biopsych.2021.03.020. PMID: 34154796Free PMC Article
DDX3X and DDX3Y are redundant in protein synthesis.
Venkataramanan S, Gadek M, Calviello L, Wilkins K, Floor SN
RNA 2021 Dec;27(12):1577-1588. Epub 2021 Sep 17 doi: 10.1261/rna.078926.121. PMID: 34535544Free PMC Article
The Role of Number of Copies, Structure, Behavior and Copy Number Variations (CNV) of the Y Chromosome in Male Infertility.
Signore F, Gulìa C, Votino R, De Leo V, Zaami S, Putignani L, Gigli S, Santini E, Bertacca L, Porrello A, Piergentili R
Genes (Basel) 2019 Dec 29;11(1) doi: 10.3390/genes11010040. PMID: 31905733Free PMC Article
Review Recent progress in identification and characterization of loci associated with sex-linked congenital cataract.
Zhang DD, Du JZ, Topolewski J, Wang XM
Genet Mol Res 2016 Jul 29;15(3) doi: 10.4238/gmr.15038600. PMID: 27525896
A fresh look at the male-specific region of the human Y chromosome.
Jangravi Z, Alikhani M, Arefnezhad B, Sharifi Tabar M, Taleahmad S, Karamzadeh R, Jadaliha M, Mousavi SA, Ahmadi Rastegar D, Parsamatin P, Vakilian H, Mirshahvaladi S, Sabbaghian M, Mohseni Meybodi A, Mirzaei M, Shahhoseini M, Ebrahimi M, Piryaei A, Moosavi-Movahedi AA, Haynes PA, Goodchild AK, Nasr-Esfahani MH, Jabbari E, Baharvand H, Sedighi Gilani MA, Gourabi H, Salekdeh GH
J Proteome Res 2013 Jan 4;12(1):6-22. Epub 2012 Dec 20 doi: 10.1021/pr300864k. PMID: 23253012

Therapy

Identification of Ribosomal Protein S4, Y-Linked 1 as a cyclosporin A plus corticosteroid resistance gene.
Chang R, Chen L, Su G, Du L, Qin Y, Xu J, Tan H, Zhou C, Cao Q, Yuan G, Kijlstra A, Yang P
J Autoimmun 2020 Aug;112:102465. Epub 2020 Apr 21 doi: 10.1016/j.jaut.2020.102465. PMID: 32331925
Chromosome Y-encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant.
Wang W, Huang H, Halagan M, Vierra-Green C, Heuer M, Brelsford JE, Haagenson M, Scheuermann RH, Telenti A, Biggs W, Pearson NM, Udell J, Spellman S, Maiers M, Kennedy CJ
Blood Adv 2018 Oct 9;2(19):2419-2429. doi: 10.1182/bloodadvances.2018019513. PMID: 30262602Free PMC Article
Zevalin(®) (ibritumomab tiuxetan): After more than a decade of treatment experience, what have we learned?
Rizzieri D
Crit Rev Oncol Hematol 2016 Sep;105:5-17. Epub 2016 Jul 16 doi: 10.1016/j.critrevonc.2016.07.008. PMID: 27497027
Impact of antenatal glucocorticosteroids on whole-genome expression in preterm babies.
Saugstad OD, Kwinta P, Wollen EJ, Bik-Multanowski M, Madetko-Talowska A, Jagła M, Tomasik T, Pietrzyk JJ
Acta Paediatr 2013 Apr;102(4):349-55. Epub 2013 Feb 11 doi: 10.1111/apa.12166. PMID: 23347050
Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.
Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S
J Clin Invest 1996 Apr 1;97(7):1597-604. doi: 10.1172/JCI118584. PMID: 8601623Free PMC Article

Prognosis

Sex-linked genetic mechanisms and atrial fibrillation risk.
Wren G, Davies W
Eur J Med Genet 2022 Apr;65(4):104459. Epub 2022 Feb 19 doi: 10.1016/j.ejmg.2022.104459. PMID: 35189376
Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.
Kido T, Tabatabai ZL, Chen X, Lau YC
Cancer Sci 2020 Aug;111(8):2987-2999. Epub 2020 Jun 21 doi: 10.1111/cas.14506. PMID: 32473614Free PMC Article
Zevalin(®) (ibritumomab tiuxetan): After more than a decade of treatment experience, what have we learned?
Rizzieri D
Crit Rev Oncol Hematol 2016 Sep;105:5-17. Epub 2016 Jul 16 doi: 10.1016/j.critrevonc.2016.07.008. PMID: 27497027
A fresh look at the male-specific region of the human Y chromosome.
Jangravi Z, Alikhani M, Arefnezhad B, Sharifi Tabar M, Taleahmad S, Karamzadeh R, Jadaliha M, Mousavi SA, Ahmadi Rastegar D, Parsamatin P, Vakilian H, Mirshahvaladi S, Sabbaghian M, Mohseni Meybodi A, Mirzaei M, Shahhoseini M, Ebrahimi M, Piryaei A, Moosavi-Movahedi AA, Haynes PA, Goodchild AK, Nasr-Esfahani MH, Jabbari E, Baharvand H, Sedighi Gilani MA, Gourabi H, Salekdeh GH
J Proteome Res 2013 Jan 4;12(1):6-22. Epub 2012 Dec 20 doi: 10.1021/pr300864k. PMID: 23253012
Male-driven evolution of DNA sequences.
Shimmin LC, Chang BH, Li WH
Nature 1993 Apr 22;362(6422):745-7. doi: 10.1038/362745a0. PMID: 8469284

Clinical prediction guides

Sex-linked genetic mechanisms and atrial fibrillation risk.
Wren G, Davies W
Eur J Med Genet 2022 Apr;65(4):104459. Epub 2022 Feb 19 doi: 10.1016/j.ejmg.2022.104459. PMID: 35189376
Roles of the Y chromosome genes in human cancers.
Kido T, Lau YF
Asian J Androl 2015 May-Jun;17(3):373-80. doi: 10.4103/1008-682X.150842. PMID: 25814157Free PMC Article
A fresh look at the male-specific region of the human Y chromosome.
Jangravi Z, Alikhani M, Arefnezhad B, Sharifi Tabar M, Taleahmad S, Karamzadeh R, Jadaliha M, Mousavi SA, Ahmadi Rastegar D, Parsamatin P, Vakilian H, Mirshahvaladi S, Sabbaghian M, Mohseni Meybodi A, Mirzaei M, Shahhoseini M, Ebrahimi M, Piryaei A, Moosavi-Movahedi AA, Haynes PA, Goodchild AK, Nasr-Esfahani MH, Jabbari E, Baharvand H, Sedighi Gilani MA, Gourabi H, Salekdeh GH
J Proteome Res 2013 Jan 4;12(1):6-22. Epub 2012 Dec 20 doi: 10.1021/pr300864k. PMID: 23253012
Sexually dimorphic gene expression in the heart of mice and men.
Isensee J, Witt H, Pregla R, Hetzer R, Regitz-Zagrosek V, Noppinger PR
J Mol Med (Berl) 2008 Jan;86(1):61-74. Epub 2007 Jul 24 doi: 10.1007/s00109-007-0240-z. PMID: 17646949Free PMC Article
X chromosome and ovarian failure.
Toniolo D, Rizzolio F
Semin Reprod Med 2007 Jul;25(4):264-71. doi: 10.1055/s-2007-980220. PMID: 17594607

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