U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 2 Nausea, CTCAE

MedGen UID:
291681
•Concept ID:
C1556473
•
Finding

Definition

Oral intake decreased without significant weight loss, dehydration or malnutrition [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Nausea, CTCAE

Professional guidelines

PubMed

Management of sotorasib-related adverse events and hepatotoxicities following anti-PD-(L)1 therapy: Experience with sotorasib in two French anti-cancer centers and practical guidance proposal.
Chour A, Basse C, Lebossé F, Bonte PE, Girard N, Duruisseaux M
Lung Cancer 2024 May;191:107789. Epub 2024 Apr 9 doi: 10.1016/j.lungcan.2024.107789. PMID: 38614068
Treatment tolerance of particle therapy in pediatric patients.
Rieber JG, Kessel KA, Witt O, Behnisch W, Kulozik AE, Debus J, Combs SE
Acta Oncol 2015 Jul;54(7):1049-55. Epub 2015 Jan 23 doi: 10.3109/0284186X.2014.998273. PMID: 25615893
Nausea, vomiting and quality of life of patients with cancer undergoing antineoplastic treatment: an evaluation by pharmacists.
de Souza CM, Visacri MB, Ferrari GB, Tuan BT, Costa AP, Barbosa CR, Lima CS, Mazzola PG, Moriel P
Int J Pharm Pract 2015 Oct;23(5):357-60. Epub 2015 Jan 9 doi: 10.1111/ijpp.12169. PMID: 25572714

Recent clinical studies

Etiology

Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study.
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Diagnosis

Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
Low Dose Decitabine Combined with Taxol and Platinum Chemotherapy to Treat Refractory/Recurrent Ovarian Cancer: An Open-Label, Single-Arm, Phase I/II Study.
Fu X, Zhang Y, Wang X, Chen M, Wang Y, Nie J, Meng Y, Han W
Curr Protein Pept Sci 2015;16(4):329-36. doi: 10.2174/138920371604150429155740. PMID: 25929868
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Nausea, vomiting and quality of life of patients with cancer undergoing antineoplastic treatment: an evaluation by pharmacists.
de Souza CM, Visacri MB, Ferrari GB, Tuan BT, Costa AP, Barbosa CR, Lima CS, Mazzola PG, Moriel P
Int J Pharm Pract 2015 Oct;23(5):357-60. Epub 2015 Jan 9 doi: 10.1111/ijpp.12169. PMID: 25572714
Evaluation of interobserver and interscale agreement in assessing late bowel toxicity after pelvic radiation in patients with carcinoma of the cervix.
Chinnachamy AN, Chopra S, Krishnatry R, Kannan S, Thomas B, Mahantshetty U, Engineer R, Shrivastava SK
Jpn J Clin Oncol 2013 May;43(5):508-14. Epub 2013 Mar 20 doi: 10.1093/jjco/hyt028. PMID: 23515269

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study.
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Prognosis

Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia.
Tola WO, Melaku T, Fufa D, Sheleme T
BMC Pediatr 2023 Feb 13;23(1):77. doi: 10.1186/s12887-023-03891-9. PMID: 36782170Free PMC Article
Twelve-month safety, tolerability and susceptibility to adverse events of prophylactic migraine therapy with erenumab: a retrospective real-world study.
Schenk H, Holle D, Nsaka M, Kleinschnitz C, Glas M, Scheffler A
J Headache Pain 2022 May 11;23(1):55. doi: 10.1186/s10194-022-01426-8. PMID: 35538414Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Clinical prediction guides

Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Recent systematic reviews

Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms.
Hauch H, Wolff BJ, Wolff JE
Anticancer Res 2022 Jan;42(1):45-52. doi: 10.21873/anticanres.15455. PMID: 34969707
Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...