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Complex regional pain syndrome type 2

MedGen UID:
2918
•Concept ID:
C0007462
•
Disease or Syndrome
Synonyms: Causalgia; Causalgia Syndrome; Causalgia Syndromes; Complex Regional Pain Syndrome Type II; CRPS Type II; Deafferentation Pain; Pain, Deafferentation; Syndrome, Causalgia; Syndromes, Causalgia; Type II Complex Regional Pain Syndrome
SNOMED CT: Complex regional pain syndrome, type II (408751001); Deafferentation pain (408751001); CRPS - Complex regional pain syndrome type II (408751001); Complex regional pain syndrome type II (408751001); Causalgia (408751001)
 
Monarch Initiative: MONDO:0020572
Orphanet: ORPHA99994

Definition

Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplex regional pain syndrome type 2

Professional guidelines

PubMed

Dorsal Root Ganglion Stimulation for the Treatment of Chronic Neuropathic Knee Pain.
Martin SC, Macey AR, Raghu A, Edwards T, Watson C, Bojanić S, FitzGerald JJ, Green AL
World Neurosurg 2020 Nov;143:e303-e308. Epub 2020 Jul 22 doi: 10.1016/j.wneu.2020.07.102. PMID: 32711140

Recent clinical studies

Etiology

Predictors of Long-Term Outcome of Thoracic Sympathectomy in Patients with Complex Regional Pain Syndrome Type 2.
Alkosha HM, Elkiran YM
World Neurosurg 2016 Aug;92:74-82. Epub 2016 May 4 doi: 10.1016/j.wneu.2016.04.101. PMID: 27155377
Systematic review of the effectiveness of mirror therapy in upper extremity function.
Ezendam D, Bongers RM, Jannink MJ
Disabil Rehabil 2009;31(26):2135-49. doi: 10.3109/09638280902887768. PMID: 19903124
Radiofrequency lesions of the stellate ganglion in chronic pain syndromes: retrospective analysis of clinical efficacy in 86 patients.
Forouzanfar T, van Kleef M, Weber WE
Clin J Pain 2000 Jun;16(2):164-8. doi: 10.1097/00002508-200006000-00010. PMID: 10870729

Diagnosis

Atypical dermatologic manifestations in complex regional pain syndrome: a case report.
Langford B, Pittelkow TP, Abcejo AS
J Med Case Rep 2022 Jun 27;16(1):251. doi: 10.1186/s13256-022-03466-9. PMID: 35754020Free PMC Article
Predictors of Long-Term Outcome of Thoracic Sympathectomy in Patients with Complex Regional Pain Syndrome Type 2.
Alkosha HM, Elkiran YM
World Neurosurg 2016 Aug;92:74-82. Epub 2016 May 4 doi: 10.1016/j.wneu.2016.04.101. PMID: 27155377
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report.
Plancarte R, Calvillo O
Spine (Phila Pa 1976) 1997 Feb 15;22(4):459-61; discussion 461-2. doi: 10.1097/00007632-199702150-00021. PMID: 9055376

Therapy

Atypical dermatologic manifestations in complex regional pain syndrome: a case report.
Langford B, Pittelkow TP, Abcejo AS
J Med Case Rep 2022 Jun 27;16(1):251. doi: 10.1186/s13256-022-03466-9. PMID: 35754020Free PMC Article
Venipuncture-induced causalgia: anatomic relations of upper extremity superficial veins and nerves, and clinical considerations.
Horowitz SH
Transfusion 2000 Sep;40(9):1036-40. doi: 10.1046/j.1537-2995.2000.40091036.x. PMID: 10988302
Radiofrequency lesions of the stellate ganglion in chronic pain syndromes: retrospective analysis of clinical efficacy in 86 patients.
Forouzanfar T, van Kleef M, Weber WE
Clin J Pain 2000 Jun;16(2):164-8. doi: 10.1097/00002508-200006000-00010. PMID: 10870729
Complex regional pain syndrome type 2 (causalgia) after automated laser discectomy. A case report.
Plancarte R, Calvillo O
Spine (Phila Pa 1976) 1997 Feb 15;22(4):459-61; discussion 461-2. doi: 10.1097/00007632-199702150-00021. PMID: 9055376

Prognosis

Predictors of Long-Term Outcome of Thoracic Sympathectomy in Patients with Complex Regional Pain Syndrome Type 2.
Alkosha HM, Elkiran YM
World Neurosurg 2016 Aug;92:74-82. Epub 2016 May 4 doi: 10.1016/j.wneu.2016.04.101. PMID: 27155377
Radiofrequency lesions of the stellate ganglion in chronic pain syndromes: retrospective analysis of clinical efficacy in 86 patients.
Forouzanfar T, van Kleef M, Weber WE
Clin J Pain 2000 Jun;16(2):164-8. doi: 10.1097/00002508-200006000-00010. PMID: 10870729

Clinical prediction guides

Repetitive Transcranial Magnetic Stimulation with Sensorimotor Training for the Treatment of Complex Regional Pain Syndrome Type 2 of the Upper Limb Case Report.
Foglia SD, Drapeau CC, Rehsi RS, Ramdeo KR, Shanthanna H, Nelson AJ
A A Pract 2024 Apr 1;18(4):e01768. Epub 2024 Mar 28 doi: 10.1213/XAA.0000000000001768. PMID: 38546353
Predictors of Long-Term Outcome of Thoracic Sympathectomy in Patients with Complex Regional Pain Syndrome Type 2.
Alkosha HM, Elkiran YM
World Neurosurg 2016 Aug;92:74-82. Epub 2016 May 4 doi: 10.1016/j.wneu.2016.04.101. PMID: 27155377

Recent systematic reviews

Systematic review of the effectiveness of mirror therapy in upper extremity function.
Ezendam D, Bongers RM, Jannink MJ
Disabil Rehabil 2009;31(26):2135-49. doi: 10.3109/09638280902887768. PMID: 19903124

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