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Grade 3 Colitis, CTCAE

MedGen UID:
293171
•Concept ID:
C1559279
•
Finding

Definition

Severe abdominal pain; peritoneal signs [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Colitis, CTCAE

Professional guidelines

PubMed

Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article

Recent clinical studies

Etiology

Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
SAKK 19/17: safety analysis of first-line durvalumab in patients with PD-L1 positive, advanced nonsmall cell lung cancer and a performance status of 2.
Mark M, Froesch P, Eboulet EI, Addeo A, Pless M, Rothschild SI, Janthur WD, Burmeister H, Friedlaender A, Schneider M, Metaxas Y, Joerger M, Wannesson L, Schwitter M, Baudoux N, Weindler S, Biaggi-Rudolf C, Früh M; Swiss Group for Clinical Cancer Research (SAKK)
Cancer Immunol Immunother 2021 May;70(5):1255-1262. Epub 2020 Nov 1 doi: 10.1007/s00262-020-02757-8. PMID: 33130956Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article
A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma.
Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, Ridolfi R, Assi H, Maraveyas A, Berman D, Siegel J, O'Day SJ
Clin Cancer Res 2009 Sep 1;15(17):5591-8. Epub 2009 Aug 11 doi: 10.1158/1078-0432.CCR-09-1024. PMID: 19671877

Diagnosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control.
Hughes MS, Zheng H, Zubiri L, Molina GE, Chen ST, Mooradian MJ, Allen IM, Reynolds KL, Dougan M
Cancer Med 2019 Sep;8(11):4986-4999. Epub 2019 Jul 9 doi: 10.1002/cam4.2397. PMID: 31286682Free PMC Article
Autoimmune Colitis and Subsequent CMV-induced Hepatitis After Treatment With Ipilimumab.
Uslu U, Agaimy A, Hundorfean G, Harrer T, Schuler G, Heinzerling L
J Immunother 2015 Jun;38(5):212-5. doi: 10.1097/CJI.0000000000000081. PMID: 25962110

Therapy

Safety and tolerability of stereotactic radiotherapy combined with durvalumab with or without tremelimumab in advanced non-small cell lung cancer, the phase I SICI trial.
Kievit H, Muntinghe-Wagenaar MB, Hijmering-Kappelle LBM, Hiddinga BI, Ubbels JF, Wijsman R, Slingers G, de Vries R, Groen HJM, Kerstjens HAM, van der Wekken AJ, Hiltermann TJN
Lung Cancer 2023 Apr;178:96-102. Epub 2023 Feb 7 doi: 10.1016/j.lungcan.2023.02.004. PMID: 36806899
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis.
Holmstroem RB, Nielsen OH, Jacobsen S, Riis LB, Theile S, Bjerrum JT, Vilmann P, Johansen JS, Boisen MK, Eefsen RHL, Marie Svane I, Nielsen DL, Chen IM
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005111. PMID: 36096534Free PMC Article
Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Prognosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Clinical prediction guides

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
SAKK 19/17: safety analysis of first-line durvalumab in patients with PD-L1 positive, advanced nonsmall cell lung cancer and a performance status of 2.
Mark M, Froesch P, Eboulet EI, Addeo A, Pless M, Rothschild SI, Janthur WD, Burmeister H, Friedlaender A, Schneider M, Metaxas Y, Joerger M, Wannesson L, Schwitter M, Baudoux N, Weindler S, Biaggi-Rudolf C, Früh M; Swiss Group for Clinical Cancer Research (SAKK)
Cancer Immunol Immunother 2021 May;70(5):1255-1262. Epub 2020 Nov 1 doi: 10.1007/s00262-020-02757-8. PMID: 33130956Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Conditional immune toxicity rate in patients with metastatic renal and urothelial cancer treated with immune checkpoint inhibitors.
Nuzzo PV, Pond GR, Abou Alaiwi S, Nassar AH, Flippot R, Curran C, Kilbridge KL, Wei XX, McGregor BA, Choueiri T, Harshman LC, Sonpavde G
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2019-000371. PMID: 32234849Free PMC Article

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