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Grade 1 Diarrhea, CTCAE

MedGen UID:
293175
•Concept ID:
C1559308
•
Finding

Definition

Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Diarrhea, CTCAE

Professional guidelines

PubMed

Late adverse events in patients with pelvic cancer after oncologic treatment-intervention and treatment effect.
Iselius S, Knutsen A, Mikiver R, Uppugunduri S
Support Care Cancer 2023 Apr 13;31(5):263. doi: 10.1007/s00520-023-07733-3. PMID: 37055633Free PMC Article
Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Management of sorafenib-related adverse events: a clinician's perspective.
Brose MS, Frenette CT, Keefe SM, Stein SM
Semin Oncol 2014 Feb;41 Suppl 2:S1-S16. Epub 2014 Jan 9 doi: 10.1053/j.seminoncol.2014.01.001. PMID: 24576654

Recent clinical studies

Etiology

Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based (177)Lu-DOTATATE treatment of NET patients.
Sundlöv A, Gleisner KS, Tennvall J, Ljungberg M, Warfvinge CF, Holgersson K, Hallqvist A, Bernhardt P, Svensson J
Eur J Nucl Med Mol Imaging 2022 Sep;49(11):3830-3840. Epub 2022 Apr 22 doi: 10.1007/s00259-022-05786-w. PMID: 35451612Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
Ganglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis.
Wu S, Bai X, Guo C, Huang Z, Ouyang H, Huang J, Zeng W
BMC Cancer 2021 Nov 2;21(1):1173. doi: 10.1186/s12885-021-08884-4. PMID: 34727879Free PMC Article
Assessment of diarrhea as side effect of oral targeted antineoplastic agents in clinical practice.
Escudero-Vilaplana V, Collado-Borrell R, Del Monte-Millán M, Hoyo-Muñoz A, Gómez Martínez-Sagrera P, Revuelta-Herrero JL, Marzal-Alfaro B, Gonzalez-Haba E, López-Tarruella Cobo S, Jerez Gilarranz Y, Herranz A, Sanjurjo M, Martin M
Support Care Cancer 2021 Aug;29(8):4673-4681. Epub 2021 Jan 28 doi: 10.1007/s00520-021-06016-z. PMID: 33506273

Diagnosis

Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.
Barnabei A, Strigari L, Corsello A, Paragliola RM, Iannantuono GM, Salvatori R, Corsello SM, Torino F
Front Endocrinol (Lausanne) 2022;13:840971. Epub 2022 Mar 21 doi: 10.3389/fendo.2022.840971. PMID: 35388297Free PMC Article
Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer.
Morgenthaler J, Köhler C, Budach V, Sehouli J, Stromberger C, Besserer A, Trommer M, Baues C, Marnitz S
Strahlenther Onkol 2021 Jun;197(6):474-486. Epub 2020 Sep 24 doi: 10.1007/s00066-020-01685-x. PMID: 32970164Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Safety and Efficacy of Cabozantinib for Metastatic Nonclear Renal Cell Carcinoma: Real-world Data From an Italian Managed Access Program.
Prisciandaro M, Ratta R, Massari F, Fornarini G, Caponnetto S, Iacovelli R, De Giorgi U, Facchini G, Scagliarini S, Sabbatini R, Caserta C, Peverelli G, Mennitto A, Verzoni E, Procopio G
Am J Clin Oncol 2019 Jan;42(1):42-45. doi: 10.1097/COC.0000000000000478. PMID: 30204614
A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.
Chung CH, Rudek MA, Kang H, Marur S, John P, Tsottles N, Bonerigo S, Veasey A, Kiess A, Quon H, Cmelak A, Murphy BA, Gilbert J
Oral Oncol 2016 Feb;53:54-9. Epub 2015 Dec 17 doi: 10.1016/j.oraloncology.2015.11.020. PMID: 26705063Free PMC Article

Therapy

Safety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer.
Shagisultanova E, Gradishar W, Brown-Glaberman U, Chalasani P, Brenner AJ, Stopeck A, Parris H, Gao D, McSpadden T, Mayordomo J, Diamond JR, Kabos P, Borges VF
Clin Cancer Res 2023 Dec 15;29(24):5021-5030. doi: 10.1158/1078-0432.CCR-23-0117. PMID: 37363965Free PMC Article
Perioperative therapy with FLOT4 significantly increases survival in patients with gastroesophageal and gastric cancer in a large real-world cohort.
Möhring C, Mańczak A, Timotheou A, Sadeghlar F, Zhou T, Mahn R, Monin MB, Toma M, Feldmann G, Brossart P, Köksal M, Sarria GR, Sommer N, Lingohr P, Jafari A, Kalff JC, Strassburg CP, Gonzalez-Carmona MA
Int J Cancer 2023 Aug 1;153(3):609-622. Epub 2023 May 5 doi: 10.1002/ijc.34511. PMID: 36919950
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis.
Holmstroem RB, Nielsen OH, Jacobsen S, Riis LB, Theile S, Bjerrum JT, Vilmann P, Johansen JS, Boisen MK, Eefsen RHL, Marie Svane I, Nielsen DL, Chen IM
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005111. PMID: 36096534Free PMC Article
Patient self-reporting of tolerability using PRO-CTCAE in a randomized double-blind, placebo-controlled phase II trial comparing gemcitabine in combination with adavosertib or placebo in patients with platinum resistant or refractory epithelial ovarian carcinoma.
Madariaga A, Mitchell SA, Pittman T, Wang L, Bowering V, Kavak N, Quintos J, Chang K, Ramsahai J, Karakasis K, Welch SA, Dhani NC, Lheureux S, Oza AM
Gynecol Oncol 2022 Nov;167(2):226-233. Epub 2022 Aug 30 doi: 10.1016/j.ygyno.2022.08.006. PMID: 36055813Free PMC Article
Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.
Barnabei A, Strigari L, Corsello A, Paragliola RM, Iannantuono GM, Salvatori R, Corsello SM, Torino F
Front Endocrinol (Lausanne) 2022;13:840971. Epub 2022 Mar 21 doi: 10.3389/fendo.2022.840971. PMID: 35388297Free PMC Article

Prognosis

Panobinostat in combination with bortezomib and dexamethasone in multiply relapsed and refractory myeloma; UK routine care cohort.
Maouche N, Kishore B, Bhatti Z, Basu S, Karim F, Sundararaman S, Collings F, Tseu B, Leary H, Ryman N, Reddy U, Vallance GD, Kothari J, Ramasamy K
PLoS One 2022;17(7):e0270854. Epub 2022 Jul 7 doi: 10.1371/journal.pone.0270854. PMID: 35797277Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
Assessment of diarrhea as side effect of oral targeted antineoplastic agents in clinical practice.
Escudero-Vilaplana V, Collado-Borrell R, Del Monte-Millán M, Hoyo-Muñoz A, Gómez Martínez-Sagrera P, Revuelta-Herrero JL, Marzal-Alfaro B, Gonzalez-Haba E, López-Tarruella Cobo S, Jerez Gilarranz Y, Herranz A, Sanjurjo M, Martin M
Support Care Cancer 2021 Aug;29(8):4673-4681. Epub 2021 Jan 28 doi: 10.1007/s00520-021-06016-z. PMID: 33506273
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article

Clinical prediction guides

Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Patient self-reporting of tolerability using PRO-CTCAE in a randomized double-blind, placebo-controlled phase II trial comparing gemcitabine in combination with adavosertib or placebo in patients with platinum resistant or refractory epithelial ovarian carcinoma.
Madariaga A, Mitchell SA, Pittman T, Wang L, Bowering V, Kavak N, Quintos J, Chang K, Ramsahai J, Karakasis K, Welch SA, Dhani NC, Lheureux S, Oza AM
Gynecol Oncol 2022 Nov;167(2):226-233. Epub 2022 Aug 30 doi: 10.1016/j.ygyno.2022.08.006. PMID: 36055813Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Assessment of diarrhea as side effect of oral targeted antineoplastic agents in clinical practice.
Escudero-Vilaplana V, Collado-Borrell R, Del Monte-Millán M, Hoyo-Muñoz A, Gómez Martínez-Sagrera P, Revuelta-Herrero JL, Marzal-Alfaro B, Gonzalez-Haba E, López-Tarruella Cobo S, Jerez Gilarranz Y, Herranz A, Sanjurjo M, Martin M
Support Care Cancer 2021 Aug;29(8):4673-4681. Epub 2021 Jan 28 doi: 10.1007/s00520-021-06016-z. PMID: 33506273

Recent systematic reviews

A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.
Sadaghiani MS, Sheikhbahaei S, Werner RA, Pienta KJ, Pomper MG, Solnes LB, Gorin MA, Wang NY, Rowe SP
Eur Urol 2021 Jul;80(1):82-94. Epub 2021 Apr 8 doi: 10.1016/j.eururo.2021.03.004. PMID: 33840558Free PMC Article
Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis.
Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM
Curr Opin Support Palliat Care 2018 Jun;12(2):187-197. doi: 10.1097/SPC.0000000000000338. PMID: 29547491

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