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Grade 3 Hemorrhoids, CTCAE

MedGen UID:
294710
•Concept ID:
C1560453
•
Finding

Definition

Severe symptoms; invasive intervention indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Hemorrhoids, CTCAE

Professional guidelines

PubMed

Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article

Recent clinical studies

Etiology

Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial.
Meixner E, Wark A, Forster T, Weykamp F, Lang K, König L, Lindel K, Oelmann-Avendano JT, Krisam J, Schneeweiss A, Ellerbrock M, Mielke T, Hörner-Rieber J, Herfarth K, Debus J, Arians N
Radiat Oncol 2023 Jan 9;18(1):5. doi: 10.1186/s13014-023-02198-4. PMID: 36624483Free PMC Article
Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
Outcomes of Squamous Cell Carcinoma Anal Canal treated with IMRT-VMAT-based Concurrent Chemoradiation: a Single Institutional Experience.
Singh K, Sathyamurthy A, Ramireddy JK, Ram TS
J Gastrointest Cancer 2022 Mar;53(1):161-169. Epub 2021 Jan 5 doi: 10.1007/s12029-020-00580-z. PMID: 33400211
Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer.
Takakusagi Y, Katoh H, Kano K, Anno W, Tsuchida K, Mizoguchi N, Serizawa I, Yoshida D, Kamada T
Radiat Oncol 2020 May 27;15(1):127. doi: 10.1186/s13014-020-01575-7. PMID: 32460889Free PMC Article
Clinical outcomes with MRI-guided image-based brachytherapy in cervical cancer: An institutional experience.
Simha V, Rai B, Patel FD, Kapoor R, Sharma SC, Singh OA, Singla V, Dhanireddy B, Ghoshal S
Brachytherapy 2018 Mar-Apr;17(2):345-351. doi: 10.1016/j.brachy.2017.09.008. PMID: 29102740

Diagnosis

Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
Evaluating the Incidence Rate of an Accelerated Short Course High Dose Rate Intravaginal Brachytherapy Complications in Patients with Endometrial Cancer.
Amouzegar Hashemi F, Vesgari Kiasari Z, Kalaghchi B, Aghili M, Gholami S, Mansouri S, Moalej S, Maddah Safaei A
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2039-2043. doi: 10.31557/APJCP.2019.20.7.2039. PMID: 31350963Free PMC Article
Long-term experience with transrectal and transperineal implantations of fiducial gold markers in the prostate for position verification in external beam radiotherapy; feasibility, toxicity and quality of life.
Moman MR, van der Heide UA, Kotte AN, van Moorselaar RJ, Bol GH, Franken SP, van Vulpen M
Radiother Oncol 2010 Jul;96(1):38-42. Epub 2010 Mar 23 doi: 10.1016/j.radonc.2010.02.027. PMID: 20334942
Grading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancer.
van der Laan HP, van den Bergh A, Schilstra C, Vlasman R, Meertens H, Langendijk JA
Int J Radiat Oncol Biol Phys 2008 Mar 15;70(4):1138-45. Epub 2007 Oct 10 doi: 10.1016/j.ijrobp.2007.07.2363. PMID: 17931794
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Therapy

Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
Outcomes of Squamous Cell Carcinoma Anal Canal treated with IMRT-VMAT-based Concurrent Chemoradiation: a Single Institutional Experience.
Singh K, Sathyamurthy A, Ramireddy JK, Ram TS
J Gastrointest Cancer 2022 Mar;53(1):161-169. Epub 2021 Jan 5 doi: 10.1007/s12029-020-00580-z. PMID: 33400211
Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer.
Takakusagi Y, Katoh H, Kano K, Anno W, Tsuchida K, Mizoguchi N, Serizawa I, Yoshida D, Kamada T
Radiat Oncol 2020 May 27;15(1):127. doi: 10.1186/s13014-020-01575-7. PMID: 32460889Free PMC Article
Early and late side effects, dosimetric parameters and quality of life after proton beam therapy and IMRT for prostate cancer: a matched-pair analysis.
Dutz A, Agolli L, Baumann M, Troost EGC, Krause M, Hölscher T, Löck S
Acta Oncol 2019 Jun;58(6):916-925. Epub 2019 Mar 18 doi: 10.1080/0284186X.2019.1581373. PMID: 30882264
Clinical outcomes with MRI-guided image-based brachytherapy in cervical cancer: An institutional experience.
Simha V, Rai B, Patel FD, Kapoor R, Sharma SC, Singh OA, Singla V, Dhanireddy B, Ghoshal S
Brachytherapy 2018 Mar-Apr;17(2):345-351. doi: 10.1016/j.brachy.2017.09.008. PMID: 29102740

Prognosis

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer.
Takakusagi Y, Katoh H, Kano K, Anno W, Tsuchida K, Mizoguchi N, Serizawa I, Yoshida D, Kamada T
Radiat Oncol 2020 May 27;15(1):127. doi: 10.1186/s13014-020-01575-7. PMID: 32460889Free PMC Article
Single dose high-dose rate (HDR) brachytherapy (BT) as monotherapy for localised prostate cancer: Early results of a UK national cohort study.
Tharmalingam H, Tsang Y, Ostler P, Wylie J, Bahl A, Lydon A, Ahmed I, Elwell C, Nikapota AR, Hoskin PJ; National UK HDR Prostate Brachytherapy Database
Radiother Oncol 2020 Feb;143:95-100. Epub 2020 Feb 7 doi: 10.1016/j.radonc.2019.12.017. PMID: 32044166
Early and late side effects, dosimetric parameters and quality of life after proton beam therapy and IMRT for prostate cancer: a matched-pair analysis.
Dutz A, Agolli L, Baumann M, Troost EGC, Krause M, Hölscher T, Löck S
Acta Oncol 2019 Jun;58(6):916-925. Epub 2019 Mar 18 doi: 10.1080/0284186X.2019.1581373. PMID: 30882264
Clinical outcomes with MRI-guided image-based brachytherapy in cervical cancer: An institutional experience.
Simha V, Rai B, Patel FD, Kapoor R, Sharma SC, Singh OA, Singla V, Dhanireddy B, Ghoshal S
Brachytherapy 2018 Mar-Apr;17(2):345-351. doi: 10.1016/j.brachy.2017.09.008. PMID: 29102740
Chronic adverse events and quality of life after radiochemotherapy in anal cancer patients. A single institution experience and review of the literature.
Fakhrian K, Sauer T, Dinkel A, Klemm S, Schuster T, Molls M, Geinitz H
Strahlenther Onkol 2013 Jun;189(6):486-94. Epub 2013 May 2 doi: 10.1007/s00066-013-0314-5. PMID: 23636349

Clinical prediction guides

Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial.
Meixner E, Wark A, Forster T, Weykamp F, Lang K, König L, Lindel K, Oelmann-Avendano JT, Krisam J, Schneeweiss A, Ellerbrock M, Mielke T, Hörner-Rieber J, Herfarth K, Debus J, Arians N
Radiat Oncol 2023 Jan 9;18(1):5. doi: 10.1186/s13014-023-02198-4. PMID: 36624483Free PMC Article
Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer.
Takakusagi Y, Katoh H, Kano K, Anno W, Tsuchida K, Mizoguchi N, Serizawa I, Yoshida D, Kamada T
Radiat Oncol 2020 May 27;15(1):127. doi: 10.1186/s13014-020-01575-7. PMID: 32460889Free PMC Article
Early and late side effects, dosimetric parameters and quality of life after proton beam therapy and IMRT for prostate cancer: a matched-pair analysis.
Dutz A, Agolli L, Baumann M, Troost EGC, Krause M, Hölscher T, Löck S
Acta Oncol 2019 Jun;58(6):916-925. Epub 2019 Mar 18 doi: 10.1080/0284186X.2019.1581373. PMID: 30882264
Chronic adverse events and quality of life after radiochemotherapy in anal cancer patients. A single institution experience and review of the literature.
Fakhrian K, Sauer T, Dinkel A, Klemm S, Schuster T, Molls M, Geinitz H
Strahlenther Onkol 2013 Jun;189(6):486-94. Epub 2013 May 2 doi: 10.1007/s00066-013-0314-5. PMID: 23636349

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