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Grade 3 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

MedGen UID:
294732
•Concept ID:
C1560554
•
Finding
Synonym: CTCAE Grade 3 Larynx mucositis/stomatitis (clinical exam)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE

Professional guidelines

PubMed

Risk factors for oral mucositis in patients with solid tumors under treatment with cetuximab: a retrospective cross-sectional study.
Martins JO, Borges MM, Malta CE, Guerra JM, Crispim AA, Coelho BC, Silva LF, Silva PG
Med Oral Patol Oral Cir Bucal 2024 Mar 1;29(2):e248-e254. doi: 10.4317/medoral.26237. PMID: 37992137Free PMC Article
Comparative Treatment Outcome in T3N0 Glottic Cancer With and Without Vocal Fold Fixation Receiving Radiation Therapy and Concurrent Low-Dose Intra-Arterial Cisplatin Infusion.
Ono T, Tanaka N, Chitose SI, Tanoue S, Kurita T, Sueyoshi S, Fukahori M, Miyata Y, Muraki K, Tsuji C, Ogo E, Hattori C, Sato K, Abe T, Umeno H
Ann Otol Rhinol Laryngol 2022 Aug;131(8):897-904. Epub 2021 Sep 25 doi: 10.1177/00034894211047789. PMID: 34565187
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465

Recent clinical studies

Etiology

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Mucosal Bridge Reconstruction: A Novel Approach for the Vocal Fold Mucosal Bridge.
Başer E, Denizoğlu İİ
Ann Otol Rhinol Laryngol 2022 Nov;131(11):1281-1286. Epub 2022 Jan 5 doi: 10.1177/00034894211053272. PMID: 34984939
Appendiceal goblet cell carcinomas have poor survival despite completion surgery.
Alabraba E, Pritchard DM, Griffin R, Diaz-Nieto R, Banks M, Cuthbertson DJ, Fenwick S
Endocrine 2021 Sep;73(3):734-744. Epub 2021 Apr 23 doi: 10.1007/s12020-021-02727-9. PMID: 33891259
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.
Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J
N Engl J Med 2003 Nov 27;349(22):2091-8. doi: 10.1056/NEJMoa031317. PMID: 14645636

Diagnosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Mucosal Bridge Reconstruction: A Novel Approach for the Vocal Fold Mucosal Bridge.
Başer E, Denizoğlu İİ
Ann Otol Rhinol Laryngol 2022 Nov;131(11):1281-1286. Epub 2022 Jan 5 doi: 10.1177/00034894211053272. PMID: 34984939
Appendiceal goblet cell carcinomas have poor survival despite completion surgery.
Alabraba E, Pritchard DM, Griffin R, Diaz-Nieto R, Banks M, Cuthbertson DJ, Fenwick S
Endocrine 2021 Sep;73(3):734-744. Epub 2021 Apr 23 doi: 10.1007/s12020-021-02727-9. PMID: 33891259
Endoscopic diagnosis value of narrow band imaging Ni classification in vocal fold leukoplakia and early glottic cancer.
Lu G, Guo W, Zhang Q, Song X
Am J Otolaryngol 2021 May-Jun;42(3):102904. Epub 2021 Jan 8 doi: 10.1016/j.amjoto.2021.102904. PMID: 33460979
Histology of metaplasia and dysplasia in Barrett's esophagus.
Yerian L
Surg Oncol Clin N Am 2009 Jul;18(3):411-22. doi: 10.1016/j.soc.2009.03.011. PMID: 19500733

Therapy

Pembrolizumab versus cetuximab concurrent with radiotherapy in patients with locally advanced squamous cell carcinoma of head and neck unfit for cisplatin (GORTEC 2015-01 PembroRad): a multicenter, randomized, phase II trial.
Tao Y, Biau J, Sun XS, Sire C, Martin L, Alfonsi M, Prevost JB, Modesto A, Lafond C, Tourani JM, Miroir J, Kaminsky MC, Coutte A, Liem X, Chautard E, Vauleon E, Drouet F, Ruffier A, Ramee JF, Waksi G, Péchery A, Wanneveich M, Guigay J, Aupérin A, Bourhis J
Ann Oncol 2023 Jan;34(1):101-110. Epub 2022 Oct 28 doi: 10.1016/j.annonc.2022.10.006. PMID: 36522816
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients.
Dragan T, Beauvois S, Moreau M, Paesmans M, Vandekerkhove C, Cordier L, Van Gestel D
Oral Oncol 2019 Nov;98:132-140. Epub 2019 Oct 3 doi: 10.1016/j.oraloncology.2019.09.012. PMID: 31586895
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.
Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J
N Engl J Med 2003 Nov 27;349(22):2091-8. doi: 10.1056/NEJMoa031317. PMID: 14645636

Prognosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Appendiceal goblet cell carcinomas have poor survival despite completion surgery.
Alabraba E, Pritchard DM, Griffin R, Diaz-Nieto R, Banks M, Cuthbertson DJ, Fenwick S
Endocrine 2021 Sep;73(3):734-744. Epub 2021 Apr 23 doi: 10.1007/s12020-021-02727-9. PMID: 33891259
Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients.
Dragan T, Beauvois S, Moreau M, Paesmans M, Vandekerkhove C, Cordier L, Van Gestel D
Oral Oncol 2019 Nov;98:132-140. Epub 2019 Oct 3 doi: 10.1016/j.oraloncology.2019.09.012. PMID: 31586895
The Relationship Between Obesity, Insulin Resistance, and Conjunctival Impression Cytology.
Dağdeviren M, Altay M, Yildiz Z, Şimşek G, Çitirik M, Ateş İ, Dağdeviren TS, Yildiz C, Şahin T
Turk Patoloji Derg 2019;35(2):119-127. doi: 10.5146/tjpath.2018.01451. PMID: 30715725
Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: a meta-analysis.
Ma J, Liu Y, Huang XL, Zhang ZY, Myers JN, Neskey DM, Zhong LP
Oral Oncol 2012 Nov;48(11):1076-84. Epub 2012 Jul 15 doi: 10.1016/j.oraloncology.2012.06.014. PMID: 22800881

Clinical prediction guides

Image Quality of High-Resolution 3-Dimensional Neck MRI Using CAIPIRINHA-VIBE and GRASP-VIBE: An Intraindividual Comparative Study.
Seo M, Yoon J, Choi Y, Nickel D, Jang J, Shin NY, Ahn KJ, Kim BS
Invest Radiol 2022 Nov 1;57(11):711-719. Epub 2022 May 6 doi: 10.1097/RLI.0000000000000886. PMID: 35703461
Mucosal Bridge Reconstruction: A Novel Approach for the Vocal Fold Mucosal Bridge.
Başer E, Denizoğlu İİ
Ann Otol Rhinol Laryngol 2022 Nov;131(11):1281-1286. Epub 2022 Jan 5 doi: 10.1177/00034894211053272. PMID: 34984939
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients.
Dragan T, Beauvois S, Moreau M, Paesmans M, Vandekerkhove C, Cordier L, Van Gestel D
Oral Oncol 2019 Nov;98:132-140. Epub 2019 Oct 3 doi: 10.1016/j.oraloncology.2019.09.012. PMID: 31586895
Histology of metaplasia and dysplasia in Barrett's esophagus.
Yerian L
Surg Oncol Clin N Am 2009 Jul;18(3):411-22. doi: 10.1016/j.soc.2009.03.011. PMID: 19500733

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