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Immune reconstitution inflammatory syndrome

MedGen UID:
295297
•Concept ID:
C1619738
•
Disease or Syndrome
Synonyms: Immune Reconstitution Disease; Immune Reconstitution Inflammatory Syndrome; Immune Reconstitution Syndrome; Immune Reconstitution Syndromes; Immune Restoration Disease; Immune Restoration Diseases; Immune Restoration Syndrome; Reconstitution Disease, Immune; Reconstitution Syndrome, Immune; Restoration Syndrome, Immune
 
Monarch Initiative: MONDO:0100185

Definition

An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune reconstitution inflammatory syndrome

Professional guidelines

PubMed

Management of active tuberculosis in adults with HIV.
Meintjes G, Brust JCM, Nuttall J, Maartens G
Lancet HIV 2019 Jul;6(7):e463-e474. doi: 10.1016/S2352-3018(19)30154-7. PMID: 31272663Free PMC Article
Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC).
Lebbe C, Garbe C, Stratigos AJ, Harwood C, Peris K, Marmol VD, Malvehy J, Zalaudek I, Hoeller C, Dummer R, Forsea AM, Kandolf-Sekulovic L, Olah J, Arenberger P, Bylaite-Bucinskiene M, Vieira R, Middleton M, Levy A, Eggermont AM, Battistella M, Spano JP, Grob JJ, Pages C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Jun;114:117-127. Epub 2019 May 13 doi: 10.1016/j.ejca.2018.12.036. PMID: 31096150
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246

Recent clinical studies

Etiology

Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors.
Boumaza X, Bonneau B, Roos-Weil D, Pinnetti C, Rauer S, Nitsch L, Del Bello A, Jelcic I, Sühs KW, Gasnault J, Goreci Y, Grauer O, Gnanapavan S, Wicklein R, Lambert N, Perpoint T, Beudel M, Clifford D, Sommet A, Cortese I, Martin-Blondel G; Immunotherapy for PML Study Group
Ann Neurol 2023 Feb;93(2):257-270. Epub 2022 Oct 17 doi: 10.1002/ana.26512. PMID: 36151879Free PMC Article
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Tuberculosis and HIV Coinfection.
Bruchfeld J, Correia-Neves M, Källenius G
Cold Spring Harb Perspect Med 2015 Feb 26;5(7):a017871. doi: 10.1101/cshperspect.a017871. PMID: 25722472Free PMC Article
Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis.
Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa
Lancet Infect Dis 2010 Apr;10(4):251-61. doi: 10.1016/S1473-3099(10)70026-8. PMID: 20334848Free PMC Article
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Diagnosis

Drug allergy and non-HIV immune reconstitution inflammatory syndrome.
Sueki H, Watanabe Y, Sugiyama S, Mizukawa Y
Allergol Int 2022 Apr;71(2):185-192. Epub 2022 Feb 27 doi: 10.1016/j.alit.2021.12.002. PMID: 35236619
Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
CNS immune reconstitution inflammatory syndrome.
Bowen L, Nath A, Smith B
Handb Clin Neurol 2018;152:167-176. doi: 10.1016/B978-0-444-63849-6.00013-X. PMID: 29604974
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis.
Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa
Lancet Infect Dis 2010 Apr;10(4):251-61. doi: 10.1016/S1473-3099(10)70026-8. PMID: 20334848Free PMC Article

Therapy

The use of TNF-α antagonists in tuberculosis to control severe paradoxical reaction or immune reconstitution inflammatory syndrome: a case series and literature review.
Armange L, Lacroix A, Petitgas P, Arvieux C, Piau-Couapel C, Poubeau P, Revest M, Tattevin P
Eur J Clin Microbiol Infect Dis 2023 Apr;42(4):413-422. Epub 2023 Feb 16 doi: 10.1007/s10096-023-04564-2. PMID: 36795280
Drug allergy and non-HIV immune reconstitution inflammatory syndrome.
Sueki H, Watanabe Y, Sugiyama S, Mizukawa Y
Allergol Int 2022 Apr;71(2):185-192. Epub 2022 Feb 27 doi: 10.1016/j.alit.2021.12.002. PMID: 35236619
Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients.
Sueki H, Mizukawa Y, Aoyama Y
J Dermatol 2018 Jan;45(1):3-9. Epub 2017 Sep 25 doi: 10.1111/1346-8138.14074. PMID: 28944502
Tuberculosis and HIV Coinfection.
Bruchfeld J, Correia-Neves M, Källenius G
Cold Spring Harb Perspect Med 2015 Feb 26;5(7):a017871. doi: 10.1101/cshperspect.a017871. PMID: 25722472Free PMC Article
Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis.
Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa
Lancet Infect Dis 2010 Apr;10(4):251-61. doi: 10.1016/S1473-3099(10)70026-8. PMID: 20334848Free PMC Article

Prognosis

Advances in Treatment of Progressive Multifocal Leukoencephalopathy.
Bernard-Valnet R, Koralnik IJ, Du Pasquier R
Ann Neurol 2021 Dec;90(6):865-873. Epub 2021 Sep 7 doi: 10.1002/ana.26198. PMID: 34405435Free PMC Article
Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease.
Cortese I, Reich DS, Nath A
Nat Rev Neurol 2021 Jan;17(1):37-51. Epub 2020 Nov 20 doi: 10.1038/s41582-020-00427-y. PMID: 33219338Free PMC Article
Whipple's disease.
El-Abassi R, Soliman MY, Williams F, England JD
J Neurol Sci 2017 Jun 15;377:197-206. Epub 2017 Feb 16 doi: 10.1016/j.jns.2017.01.048. PMID: 28477696
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Clinical prediction guides

Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors.
Boumaza X, Bonneau B, Roos-Weil D, Pinnetti C, Rauer S, Nitsch L, Del Bello A, Jelcic I, Sühs KW, Gasnault J, Goreci Y, Grauer O, Gnanapavan S, Wicklein R, Lambert N, Perpoint T, Beudel M, Clifford D, Sommet A, Cortese I, Martin-Blondel G; Immunotherapy for PML Study Group
Ann Neurol 2023 Feb;93(2):257-270. Epub 2022 Oct 17 doi: 10.1002/ana.26512. PMID: 36151879Free PMC Article
Drug allergy and non-HIV immune reconstitution inflammatory syndrome.
Sueki H, Watanabe Y, Sugiyama S, Mizukawa Y
Allergol Int 2022 Apr;71(2):185-192. Epub 2022 Feb 27 doi: 10.1016/j.alit.2021.12.002. PMID: 35236619
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.
Cortese I, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco M, Ryschkewitsch C, Major EO, Ohayon J, Schindler MK, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A
N Engl J Med 2019 Apr 25;380(17):1597-1605. Epub 2019 Apr 10 doi: 10.1056/NEJMoa1815039. PMID: 30969503
Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients.
Sueki H, Mizukawa Y, Aoyama Y
J Dermatol 2018 Jan;45(1):3-9. Epub 2017 Sep 25 doi: 10.1111/1346-8138.14074. PMID: 28944502
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Recent systematic reviews

Immune reconstitution inflammatory syndrome in the lung in non-human immunodeficiency virus patients.
Fujita J
Respir Investig 2020 Jan;58(1):36-44. Epub 2019 Nov 29 doi: 10.1016/j.resinv.2019.11.001. PMID: 31791908
Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review.
Badaró R, Gonçalves LO, Gois LL, Maia ZP, Benson C, Grassi MF
J Int Assoc Provid AIDS Care 2015 Sep-Oct;14(5):402-7. Epub 2014 Oct 20 doi: 10.1177/2325957414555225. PMID: 25331225Free PMC Article
Tuberculosis Immune Reconstitution Inflammatory Syndrome in children initiating Antiretroviral Therapy for HIV infection: A systematic literature review.
Link-Gelles R, Moultrie H, Sawry S, Murdoch D, Van Rie A
Pediatr Infect Dis J 2014 May;33(5):499-503. doi: 10.1097/INF.0000000000000142. PMID: 24736441Free PMC Article
Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis.
Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa
Lancet Infect Dis 2010 Apr;10(4):251-61. doi: 10.1016/S1473-3099(10)70026-8. PMID: 20334848Free PMC Article
Immune reconstitution inflammatory syndrome associated with Mycobacterium tuberculosis infection: a systematic review.
Leone S, Nicastri E, Giglio S, Narciso P, Ippolito G, Acone N
Int J Infect Dis 2010 Apr;14(4):e283-91. Epub 2009 Aug 4 doi: 10.1016/j.ijid.2009.05.016. PMID: 19656712

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