U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Candidiasis, Invasive

MedGen UID:
296300
•Concept ID:
C1609535
•
Disease or Syndrome
Synonyms: Candidiases, Invasive; Invasive Candidiases; Invasive Candidiasis
 
Monarch Initiative: MONDO:0044067

Definition

A fungal infection by any of the Candida species in a sterile body compartment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCandidiasis, Invasive

Professional guidelines

PubMed

Neonatal invasive candidiasis: updates on clinical management and prevention.
Kilpatrick R, Scarrow E, Hornik C, Greenberg RG
Lancet Child Adolesc Health 2022 Jan;6(1):60-70. Epub 2021 Oct 19 doi: 10.1016/S2352-4642(21)00272-8. PMID: 34672994
Rezafungin: a novel antifungal for the treatment of invasive candidiasis.
Ham YY, Lewis JS 2nd, Thompson GR 3rd
Future Microbiol 2021 Jan;16(1):27-36. doi: 10.2217/fmb-2020-0217. PMID: 33438477
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD
Clin Infect Dis 2016 Feb 15;62(4):e1-50. Epub 2015 Dec 16 doi: 10.1093/cid/civ933. PMID: 26679628Free PMC Article

Recent clinical studies

Etiology

Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial.
Thompson GR 3rd, Soriano A, Cornely OA, Kullberg BJ, Kollef M, Vazquez J, Honore PM, Bassetti M, Pullman J, Chayakulkeeree M, Poromanski I, Dignani C, Das AF, Sandison T, Pappas PG; ReSTORE trial investigators
Lancet 2023 Jan 7;401(10370):49-59. Epub 2022 Nov 25 doi: 10.1016/S0140-6736(22)02324-8. PMID: 36442484
Neonatal invasive candidiasis: updates on clinical management and prevention.
Kilpatrick R, Scarrow E, Hornik C, Greenberg RG
Lancet Child Adolesc Health 2022 Jan;6(1):60-70. Epub 2021 Oct 19 doi: 10.1016/S2352-4642(21)00272-8. PMID: 34672994
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group.
Bassetti M, Azoulay E, Kullberg BJ, Ruhnke M, Shoham S, Vazquez J, Giacobbe DR, Calandra T
Clin Infect Dis 2021 Mar 12;72(Suppl 2):S121-S127. doi: 10.1093/cid/ciaa1751. PMID: 33709127
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387

Diagnosis

Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group.
Bassetti M, Azoulay E, Kullberg BJ, Ruhnke M, Shoham S, Vazquez J, Giacobbe DR, Calandra T
Clin Infect Dis 2021 Mar 12;72(Suppl 2):S121-S127. doi: 10.1093/cid/ciaa1751. PMID: 33709127
Invasive Candidiasis.
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
Invasive Candidiasis.
Kullberg BJ, Arendrup MC
N Engl J Med 2015 Oct 8;373(15):1445-56. doi: 10.1056/NEJMra1315399. PMID: 26444731

Therapy

Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial.
Thompson GR 3rd, Soriano A, Cornely OA, Kullberg BJ, Kollef M, Vazquez J, Honore PM, Bassetti M, Pullman J, Chayakulkeeree M, Poromanski I, Dignani C, Das AF, Sandison T, Pappas PG; ReSTORE trial investigators
Lancet 2023 Jan 7;401(10370):49-59. Epub 2022 Nov 25 doi: 10.1016/S0140-6736(22)02324-8. PMID: 36442484
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
Invasive Candidiasis.
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
Invasive Candidiasis.
Kullberg BJ, Arendrup MC
N Engl J Med 2015 Oct 8;373(15):1445-56. doi: 10.1056/NEJMra1315399. PMID: 26444731

Prognosis

New Perspectives on Antimicrobial Agents: Isavuconazole.
Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd
Antimicrob Agents Chemother 2022 Sep 20;66(9):e0017722. Epub 2022 Aug 15 doi: 10.1128/aac.00177-22. PMID: 35969068Free PMC Article
Invasive candidiasis in critical care: challenges and future directions.
Logan C, Martin-Loeches I, Bicanic T
Intensive Care Med 2020 Nov;46(11):2001-2014. Epub 2020 Sep 29 doi: 10.1007/s00134-020-06240-x. PMID: 32990778
Update on management of invasive candidiasis.
Candel FJ, Pazos Pacheco C, Ruiz-Camps I, Maseda E, Sánchez-Benito MR, Montero A, Puig M, Gilsanz F, Aguilar J, Matesanz M
Rev Esp Quimioter 2017 Dec;30(6):397-406. Epub 2017 Nov 6 PMID: 29115366
Invasive candidiasis in the neutropenic patient.
Fortún J, Gioia F
Rev Esp Quimioter 2017 Sep;30 Suppl 1:22-25. PMID: 28882010
Invasive candidiasis: from mycobiome to infection, therapy, and prevention.
Lagunes L, Rello J
Eur J Clin Microbiol Infect Dis 2016 Aug;35(8):1221-6. Epub 2016 May 4 doi: 10.1007/s10096-016-2658-0. PMID: 27146877

Clinical prediction guides

New Perspectives on Antimicrobial Agents: Isavuconazole.
Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd
Antimicrob Agents Chemother 2022 Sep 20;66(9):e0017722. Epub 2022 Aug 15 doi: 10.1128/aac.00177-22. PMID: 35969068Free PMC Article
Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG
Clin Infect Dis 2021 Dec 6;73(11):e3647-e3655. doi: 10.1093/cid/ciaa1380. PMID: 32955088Free PMC Article
Invasive candidiasis in critical care: challenges and future directions.
Logan C, Martin-Loeches I, Bicanic T
Intensive Care Med 2020 Nov;46(11):2001-2014. Epub 2020 Sep 29 doi: 10.1007/s00134-020-06240-x. PMID: 32990778
Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses.
Chow NA, Muñoz JF, Gade L, Berkow EL, Li X, Welsh RM, Forsberg K, Lockhart SR, Adam R, Alanio A, Alastruey-Izquierdo A, Althawadi S, Araúz AB, Ben-Ami R, Bharat A, Calvo B, Desnos-Ollivier M, Escandón P, Gardam D, Gunturu R, Heath CH, Kurzai O, Martin R, Litvintseva AP, Cuomo CA
mBio 2020 Apr 28;11(2) doi: 10.1128/mBio.03364-19. PMID: 32345637Free PMC Article
Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial.
Kullberg BJ, Viscoli C, Pappas PG, Vazquez J, Ostrosky-Zeichner L, Rotstein C, Sobel JD, Herbrecht R, Rahav G, Jaruratanasirikul S, Chetchotisakd P, Van Wijngaerden E, De Waele J, Lademacher C, Engelhardt M, Kovanda L, Croos-Dabrera R, Fredericks C, Thompson GR
Clin Infect Dis 2019 May 30;68(12):1981-1989. doi: 10.1093/cid/ciy827. PMID: 30289478

Recent systematic reviews

Invasive fungal infections in acute and chronic liver impairment: A systematic review.
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis.
Thomas-Rüddel DO, Schlattmann P, Pletz M, Kurzai O, Bloos F
Chest 2022 Feb;161(2):345-355. Epub 2021 Oct 18 doi: 10.1016/j.chest.2021.08.081. PMID: 34673022Free PMC Article
Comparison of Antifungal Prophylaxis Drugs in Patients With Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-analysis.
Wang J, Zhou M, Xu JY, Zhou RF, Chen B, Wan Y
JAMA Netw Open 2020 Oct 1;3(10):e2017652. doi: 10.1001/jamanetworkopen.2020.17652. PMID: 33030550Free PMC Article
The Economic Burden of Candidemia and Invasive Candidiasis: A Systematic Review.
Wan Ismail WNA, Jasmi N, Khan TM, Hong YH, Neoh CF
Value Health Reg Issues 2020 May;21:53-58. Epub 2019 Oct 22 doi: 10.1016/j.vhri.2019.07.002. PMID: 31648147
PCR diagnosis of invasive candidiasis: systematic review and meta-analysis.
Avni T, Leibovici L, Paul M
J Clin Microbiol 2011 Feb;49(2):665-70. Epub 2010 Nov 24 doi: 10.1128/JCM.01602-10. PMID: 21106797Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...