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Skin epithelioid hemangioma

MedGen UID:
297
•Concept ID:
C0002989
•
Neoplastic Process
Synonym: Angiolymphoid Hyperplasia with Eosinophilia
SNOMED CT: Epithelioid hemangioma of skin (400131007); Histiocytoid hemangioma of skin (400131007); Angiolymphoid hyperplasia with eosinophilia of skin (400131007)
 
Monarch Initiative: MONDO:0001939

Definition

A hemangioma arising from the skin. It is characterized by the presence of epithelioid endothelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin epithelioid hemangioma

Professional guidelines

PubMed

Kimura's disease: clinical characteristics, management and outcome of 20 cases from China.
Zhang Y, Bao H, Zhang X, Yang F, Liu Y, Li H, Lu J, Liu Y
Clin Exp Rheumatol 2022 Mar;40(3):532-538. Epub 2021 Mar 22 doi: 10.55563/clinexprheumatol/lahgfo. PMID: 33769269
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Eosinophilic hyperplastic lymphogranuloma: Clinical diagnosis and treatment experience of 41 cases.
Jiang Y, Hua Q, Ren J, Zeng F, Sheng J, Liao H, Zhang Z, Guan H
Am J Otolaryngol 2017 Sep-Oct;38(5):626-629. Epub 2017 Jul 12 doi: 10.1016/j.amjoto.2017.07.007. PMID: 28729131

Recent clinical studies

Etiology

Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Epithelioid hemangioma involving large arteries in the skin.
Markidan J, Hardy N, Kallen M, Ma L
J Cutan Pathol 2022 Apr;49(4):377-380. Epub 2021 Nov 18 doi: 10.1111/cup.14166. PMID: 34755378
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Targetoid hemosiderotic hemangioma.
Santa Cruz DJ, Aronberg J
J Am Acad Dermatol 1988 Sep;19(3):550-8. doi: 10.1016/s0190-9622(88)70211-x. PMID: 3170814
Epithelioid hemangioendothelioma and related lesions.
Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM
Semin Diagn Pathol 1986 Nov;3(4):259-87. PMID: 3303234

Diagnosis

What is new in endothelial neoplasia?
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Kimura's Disease.
Wang X, Ma Y, Wang Z
J Craniofac Surg 2019 Jul;30(5):e415-e418. doi: 10.1097/SCS.0000000000005430. PMID: 31299798
Kimura disease.
Zhou P, Zhang W, Shi W, Zhang Y
Dermatol Online J 2017 Oct 15;23(10) PMID: 29469792
Angiolymphoid hyperplasia with eosinophilia.
Guo R, Gavino AC
Arch Pathol Lab Med 2015 May;139(5):683-6. doi: 10.5858/arpa.2013-0334-RS. PMID: 25927152
Kimura disease.
Abuel-Haija M, Hurford MT
Arch Pathol Lab Med 2007 Apr;131(4):650-1. doi: 10.5858/2007-131-650-KD. PMID: 17425383

Therapy

Kimura's disease: a case report.
Anbessie ZM
J Med Case Rep 2024 Feb 6;18(1):44. doi: 10.1186/s13256-024-04352-2. PMID: 38317181Free PMC Article
Anti-immunoglobulin E provides an additional therapy to conventional steroids for Kimura's disease.
Ao S, Huang G, Tang X, Zhu Z, Han J, Wang F, Zhai W
J Dermatol 2024 Apr;51(4):602-606. Epub 2023 Nov 10 doi: 10.1111/1346-8138.17021. PMID: 37950550
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease.
Ye P, Wei T, Yu GY, Wu LL, Peng X
J Craniofac Surg 2016 Jan;27(1):170-4. doi: 10.1097/SCS.0000000000002337. PMID: 26674917
Disseminated granuloma faciale.
Zargari O
Int J Dermatol 2004 Mar;43(3):210-2. doi: 10.1111/j.1365-4632.2004.02099.x. PMID: 15009395

Prognosis

A retrospective study of 20 patients with Kimura's disease from China.
Zhuang S, Chen X, Chen W, Li C, Wang T, Lin Q, Wang D
Acta Otolaryngol 2022 Mar-Apr;142(3-4):357-362. Epub 2022 Apr 5 doi: 10.1080/00016489.2022.2055139. PMID: 35382684
Cutaneous tumors in pregnancy.
Walker JL, Wang AR, Kroumpouzos G, Weinstock MA
Clin Dermatol 2016 May-Jun;34(3):359-67. Epub 2016 Feb 9 doi: 10.1016/j.clindermatol.2016.02.008. PMID: 27265074
Lymphocytic infiltrations of face.
Engin B, Songür A, Kutlubay Z, Serdaroğlu S
Clin Dermatol 2014 Jan-Feb;32(1):101-8. doi: 10.1016/j.clindermatol.2013.05.031. PMID: 24314383
Kimura disease: review of the literature.
Sun QF, Xu DZ, Pan SH, Ding JG, Xue ZQ, Miao CS, Cao GJ, Jin DJ
Intern Med J 2008 Aug;38(8):668-72. doi: 10.1111/j.1445-5994.2008.01711.x. PMID: 18808562
Kimura disease.
Abuel-Haija M, Hurford MT
Arch Pathol Lab Med 2007 Apr;131(4):650-1. doi: 10.5858/2007-131-650-KD. PMID: 17425383

Clinical prediction guides

Clinical effects of dupilumab: A novel treatment for Kimura disease.
Shang BS, Hsiao CH, Tsao TF, Liao YY, Lin WL, Lee WI, Lue KH
Immun Inflamm Dis 2023 Nov;11(11):e1084. doi: 10.1002/iid3.1084. PMID: 38018601Free PMC Article
Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions.
Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Kimura's disease successively affecting multiple body parts: a case-based literature review.
Yang B, Liao H, Wang M, Long Q, Zhong H, Luo L, Liu Z, Cheng X
BMC Ophthalmol 2022 Apr 2;22(1):154. doi: 10.1186/s12886-022-02378-y. PMID: 35366827Free PMC Article
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases.
Luzar B, Ieremia E, Antonescu CR, Zhang L, Calonje E
Mod Pathol 2020 Aug;33(8):1527-1536. Epub 2020 Feb 24 doi: 10.1038/s41379-020-0505-4. PMID: 32094426Free PMC Article
FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma.
Hung YP, Fletcher CD, Hornick JL
Am J Surg Pathol 2017 May;41(5):596-606. doi: 10.1097/PAS.0000000000000795. PMID: 28009608

Recent systematic reviews

Treatment algorithm for Kimura's disease: A systematic review and meta-analysis of treatment modalities and prognostic predictors.
Lee CC, Feng IJ, Chen YT, Weng SF, Chan LP, Lai CS, Lin SD, Kuo YR
Int J Surg 2022 Apr;100:106591. Epub 2022 Mar 5 doi: 10.1016/j.ijsu.2022.106591. PMID: 35259522
Kimura Disease: A Case Series and Systematic Review of Clinico-radiological Features.
Sangwan A, Goyal A, Bhalla AS, Kumar A, Sharma R, Arava S, Dawar R
Curr Probl Diagn Radiol 2022 Jan-Feb;51(1):130-142. Epub 2020 Nov 17 doi: 10.1067/j.cpradiol.2020.10.003. PMID: 33250297
Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review.
Adler BL, Krausz AE, Minuti A, Silverberg JI, Lev-Tov H
J Am Acad Dermatol 2016 Mar;74(3):506-12.e11. Epub 2015 Dec 11 doi: 10.1016/j.jaad.2015.10.011. PMID: 26685720

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