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Folliculotropic mycosis fungoides

MedGen UID:
302080
•Concept ID:
C1627767
•
Disease or Syndrome
Synonyms: Alopecia mucinosa (T cell lymphoma); alopecia mucinosa (t cell lymphoma); Follicular mucinosis type mycosis fungoides; follicular mucinosis type mycosis fungoides; Follicular Mycosis Fungoides; Follicular mycosis fungoides; follicular mycosis fungoides; Folliculotropic Mycosis Fungoides; folliculotropic mycosis fungoides; Mycosis Fungoides-Associated Follicular Mucinosis; Mycosis fungoides-associated follicular mucinosis; mycosis fungoides-associated follicular mucinosis
SNOMED CT: Follicular mucinosis type mycosis fungoides (404109006); Folliculotropic mycosis fungoides (404109006); Alopecia mucinosa (T cell lymphoma) (404109006); Follicular mycosis fungoides (418628003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015808
Orphanet: ORPHA178512

Definition

A rare variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, characterized by the presence of folliculotropic infiltrates in patch-plaque lesions usually involving the head and neck area. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFolliculotropic mycosis fungoides
Follow this link to review classifications for Folliculotropic mycosis fungoides in Orphanet.

Professional guidelines

PubMed

Paediatric Mycosis Fungoides: Clinical Variants, Treatment Modalities and Response to Therapy.
Mirmovich Morvay O, Ramon M, Khamaysi Z, Avitan-Hersh E
Acta Derm Venereol 2023 Jul 14;103:adv6557. doi: 10.2340/actadv.v103.6557. PMID: 37449370Free PMC Article
Treatment of Early Folliculotropic Mycosis Fungoides with Special Focus on Psoralen plus Ultraviolet A.
Amitay-Laish I, Prag-Naveh H, Dalal A, Pavlovsky L, Feinmesser M, Hodak E
Acta Derm Venereol 2018 Nov 5;98(10):951-955. doi: 10.2340/00015555-3013. PMID: 30085321
Recommendations for treatment in folliculotropic mycosis fungoides: report of the Dutch Cutaneous Lymphoma Group.
van Santen S, van Doorn R, Neelis KJ, Daniëls LA, Horváth B, Bruijn MS, Sanders CJG, van Rossum MM, de Haas ERM, Veraart JCJM, Bekkenk MW, Vermeer MH, Willemze R
Br J Dermatol 2017 Jul;177(1):223-228. Epub 2017 May 11 doi: 10.1111/bjd.15355. PMID: 28132406

Recent clinical studies

Etiology

Folliculotropic Mycosis Fungoides in a Latin American Hospital: Survival Analysis.
Pérez HC, Morales S, Enciso L, Carreño JA, Rueda X
Actas Dermosifiliogr 2022 Nov-Dec;113(10):930-937. Epub 2022 Aug 10 doi: 10.1016/j.ad.2022.07.018. PMID: 35963330
Acneiform Presentations of Folliculotropic Mycosis Fungoides.
Shamim H, Riemer C, Weenig R, Sokumbi O, Sciallis G, McEvoy M, Mischke D, Comfere N
Am J Dermatopathol 2021 Feb 1;43(2):85-92. doi: 10.1097/DAD.0000000000001698. PMID: 33492839
Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis.
Giberson M, Mourad A, Gniadecki R
Dermatology 2017;233(4):320-325. Epub 2017 Nov 24 doi: 10.1159/000484203. PMID: 29169156
Leonine facies (LF) and mycosis fungoides (MF): A single-center study and systematic review of the literature.
Brown DN, Wieser I, Wang C, Dabaja BS, Duvic M
J Am Acad Dermatol 2015 Dec;73(6):976-86. Epub 2015 Oct 21 doi: 10.1016/j.jaad.2015.09.017. PMID: 26476898
Folliculotropic mycosis fungoides: clinicopathological analysis of 17 patients.
Marschalkó M, Erős N, Kontár O, Hidvégi B, Telek J, Hársing J, Jókai H, Bottlik G, Rajnai H, Szepesi Á, Matolcsy A, Kárpáti S, Csomor J
J Eur Acad Dermatol Venereol 2015 May;29(5):964-72. Epub 2014 Nov 18 doi: 10.1111/jdv.12743. PMID: 25406034

Diagnosis

Folliculotropic Mycosis Fungoides.
Gu AK, Shi J, Zhang Y
JAMA Dermatol 2022 Mar 1;158(3):316. doi: 10.1001/jamadermatol.2021.5181. PMID: 35107567
Acneiform Presentations of Folliculotropic Mycosis Fungoides.
Shamim H, Riemer C, Weenig R, Sokumbi O, Sciallis G, McEvoy M, Mischke D, Comfere N
Am J Dermatopathol 2021 Feb 1;43(2):85-92. doi: 10.1097/DAD.0000000000001698. PMID: 33492839
Cutaneous lymphomas-An update 2019.
Kempf W, Zimmermann AK, Mitteldorf C
Hematol Oncol 2019 Jun;37 Suppl 1:43-47. doi: 10.1002/hon.2584. PMID: 31187534
Folliculotropic mycosis fungoides.
Feng H, Beasley J, Meehan S, Liebman TN
Dermatol Online J 2018 Dec 15;24(12) PMID: 30677794
Folliculotropic mycosis fungoides.
Mitteldorf C, Stadler R, Sander CA, Kempf W
J Dtsch Dermatol Ges 2018 May;16(5):543-557. Epub 2018 May 4 doi: 10.1111/ddg.13514. PMID: 29726638

Therapy

Recommendations for treatment in folliculotropic mycosis fungoides: report of the Dutch Cutaneous Lymphoma Group.
van Santen S, van Doorn R, Neelis KJ, Daniëls LA, Horváth B, Bruijn MS, Sanders CJG, van Rossum MM, de Haas ERM, Veraart JCJM, Bekkenk MW, Vermeer MH, Willemze R
Br J Dermatol 2017 Jul;177(1):223-228. Epub 2017 May 11 doi: 10.1111/bjd.15355. PMID: 28132406
Clinical Efficacy of Romidepsin in Tumor Stage and Folliculotropic Mycosis Fungoides.
Foss F, Duvic M, Lerner A, Waksman J, Whittaker S
Clin Lymphoma Myeloma Leuk 2016 Nov;16(11):637-643. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.009. PMID: 27637428
Alopecias due to drugs and other skin and systemic disorders.
Guzmán-Sánchez D, Asz-Sigall D
Curr Probl Dermatol 2015;47:97-106. Epub 2015 Feb 20 doi: 10.1159/000369409. PMID: 26370648
Folliculotropic mycosis fungoides: clinicopathological features and outcome in a series of 20 cases.
Muniesa C, Estrach T, Pujol RM, Gallardo F, Garcia-Muret P, Climent J, Servitje O
J Am Acad Dermatol 2010 Mar;62(3):418-26. Epub 2010 Jan 15 doi: 10.1016/j.jaad.2009.03.014. PMID: 20079954
Folliculotropic mycosis fungoides.
Hunzeker CM, Fangman W, Latkowski JA
Dermatol Online J 2007 Jan 27;13(1):5. PMID: 17511938

Prognosis

Acneiform Presentations of Folliculotropic Mycosis Fungoides.
Shamim H, Riemer C, Weenig R, Sokumbi O, Sciallis G, McEvoy M, Mischke D, Comfere N
Am J Dermatopathol 2021 Feb 1;43(2):85-92. doi: 10.1097/DAD.0000000000001698. PMID: 33492839
Cutaneous lymphomas-An update 2019.
Kempf W, Zimmermann AK, Mitteldorf C
Hematol Oncol 2019 Jun;37 Suppl 1:43-47. doi: 10.1002/hon.2584. PMID: 31187534
Folliculotropic mycosis fungoides.
Feng H, Beasley J, Meehan S, Liebman TN
Dermatol Online J 2018 Dec 15;24(12) PMID: 30677794
Folliculotropic mycosis fungoides.
Mitteldorf C, Stadler R, Sander CA, Kempf W
J Dtsch Dermatol Ges 2018 May;16(5):543-557. Epub 2018 May 4 doi: 10.1111/ddg.13514. PMID: 29726638
Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis.
Giberson M, Mourad A, Gniadecki R
Dermatology 2017;233(4):320-325. Epub 2017 Nov 24 doi: 10.1159/000484203. PMID: 29169156

Clinical prediction guides

Folliculotropic Mycosis Fungoides in a Latin American Hospital: Survival Analysis.
Pérez HC, Morales S, Enciso L, Carreño JA, Rueda X
Actas Dermosifiliogr 2022 Nov-Dec;113(10):930-937. Epub 2022 Aug 10 doi: 10.1016/j.ad.2022.07.018. PMID: 35963330
Acneiform Presentations of Folliculotropic Mycosis Fungoides.
Shamim H, Riemer C, Weenig R, Sokumbi O, Sciallis G, McEvoy M, Mischke D, Comfere N
Am J Dermatopathol 2021 Feb 1;43(2):85-92. doi: 10.1097/DAD.0000000000001698. PMID: 33492839
Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis.
Giberson M, Mourad A, Gniadecki R
Dermatology 2017;233(4):320-325. Epub 2017 Nov 24 doi: 10.1159/000484203. PMID: 29169156
Folliculotropic mycosis fungoides: clinicopathological analysis of 17 patients.
Marschalkó M, Erős N, Kontár O, Hidvégi B, Telek J, Hársing J, Jókai H, Bottlik G, Rajnai H, Szepesi Á, Matolcsy A, Kárpáti S, Csomor J
J Eur Acad Dermatol Venereol 2015 May;29(5):964-72. Epub 2014 Nov 18 doi: 10.1111/jdv.12743. PMID: 25406034
Clinical and histopathological features of folliculotropic mycosis fungoides: a Norwegian patient series.
Mantaka P, Helsing P, Gjersvik P, Bassarova A, Clausen OP, Delabie J
Acta Derm Venereol 2013 May;93(3):325-9. doi: 10.2340/00015555-1476. PMID: 23053197

Recent systematic reviews

Dermoscopic and trichoscopic features of primary cutaneous lymphomas - systematic review.
Sławińska M, Sokołowska-Wojdyło M, Olszewska B, Nowicki RJ, Sobjanek M, Zalaudek I
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1470-1484. Epub 2021 Apr 27 doi: 10.1111/jdv.17219. PMID: 33710688
Leonine facies (LF) and mycosis fungoides (MF): A single-center study and systematic review of the literature.
Brown DN, Wieser I, Wang C, Dabaja BS, Duvic M
J Am Acad Dermatol 2015 Dec;73(6):976-86. Epub 2015 Oct 21 doi: 10.1016/j.jaad.2015.09.017. PMID: 26476898
Folliculotropic mycosis fungoides: single-center study and systematic review.
Lehman JS, Cook-Norris RH, Weed BR, Weenig RH, Gibson LE, Weaver AL, Pittelkow MR
Arch Dermatol 2010 Jun;146(6):607-13. doi: 10.1001/archdermatol.2010.101. PMID: 20566923

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