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Invasive hydatidiform mole

MedGen UID:
3055
Concept ID:
C0008493
Neoplastic Process
Synonyms: Chorioadenoma; Chorioadenomas; Hydatidiform Mole, Invasive; Hydatidiform Moles, Invasive; Invasive Hydatidiform Mole; Invasive Hydatidiform Moles; Invasive Mole; Invasive Moles; Mole, Invasive; Mole, Invasive Hydatidiform; Moles, Invasive; Moles, Invasive Hydatidiform
SNOMED CT: Invasive hydatidiform mole (416669000); Chorioadenoma (416669000); Chorioadenoma destruens (416669000); IM - Invasive mole (416669000); Invasive mole (416669000); Invasive mole - placenta (416669000); Invasive hydatidiform mole (18799007); Malignant hydatidiform mole (18799007); Chorioadenoma destruens (18799007); Chorioadenoma (18799007); Invasive mole (18799007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020549
Orphanet: ORPHA99925

Definition

A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometriumand histologically characterized hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive hydatidiform mole

Professional guidelines

PubMed

Mitric C, Yang K, Bhat G, Lheureux S, Laframboise S, Li X, Bouchard-Fortier G
Int J Gynecol Cancer 2023 Nov 6;33(11):1724-1732. doi: 10.1136/ijgc-2023-004526. PMID: 37723102
Weng D, Han T, Dong J, Zhang M, Mi Y, He Y, Li X, Zhu X
Medicine (Baltimore) 2022 Feb 4;101(5):e28768. doi: 10.1097/MD.0000000000028768. PMID: 35119039Free PMC Article
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

Recent clinical studies

Etiology

Heřman J, Rob L, Robová H, Drochýtek V, Hruda M, Pichlík T, Kujal P, Drozenová J
Ceska Gynekol 2019 Winter;84(6):418-424. PMID: 31948249
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Diagnosis

Qian J, Xu S, Chen L
BMC Womens Health 2023 Nov 2;23(1):566. doi: 10.1186/s12905-023-02727-z. PMID: 37919704Free PMC Article
Habek D
Z Geburtshilfe Neonatol 2022 Aug;226(4):282. Epub 2022 Mar 9 doi: 10.1055/a-1742-3767. PMID: 35263771
Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Suzuki S, Takahashi K, Obayashi S, Kitazawa M, Kuroda H, Fukasawa I
J Obstet Gynaecol Res 2021 Jan;47(1):420-424. Epub 2020 Oct 20 doi: 10.1111/jog.14537. PMID: 33078868
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Therapy

von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Franke HR, Vermorken JB, von Kessel H, Dijkhuizen GH, Calame JJ, Stolk JG
Eur J Obstet Gynecol Reprod Biol 1986 Mar;21(3):181-5. doi: 10.1016/0028-2243(86)90034-1. PMID: 3007229
Lurain JR, Brewer JI
Semin Oncol 1982 Jun;9(2):174-80. PMID: 6289460
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Prognosis

Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
Hansen LA, Clayton BD
Drug Intell Clin Pharm 1984 Jul-Aug;18(7-8):569-76. doi: 10.1177/106002808401800703. PMID: 6086260

Clinical prediction guides

Liu X, Pan X, Liu H, Ma X
Front Cell Infect Microbiol 2021;11:704100. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.704100. PMID: 34513727Free PMC Article
Yamamoto E, Trinh TD, Sekiya Y, Tamakoshi K, Nguyen XP, Nishino K, Niimi K, Kotani T, Kajiyama H, Shibata K, Le QT, Kikkawa F
Nagoya J Med Sci 2020 May;82(2):183-191. doi: 10.18999/nagjms.82.2.183. PMID: 32581399Free PMC Article
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A
J Matern Fetal Neonatal Med 2018 Feb;31(3):271-277. Epub 2017 Feb 2 doi: 10.1080/14767058.2017.1281906. PMID: 28093002
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885

Recent systematic reviews

von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

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